PIM-Kinase Inhibitor X, CX-6258 - Calbiochem
- CAS No.
- Chemical Name:
- PIM-Kinase Inhibitor X, CX-6258 - Calbiochem
- Synonyms
- PIM-Kinase Inhibitor X, CX-6258 - Calbiochem
- CBNumber:
- CB84817772
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
PIM-Kinase Inhibitor X, CX-6258 - Calbiochem price More Price(1)
PIM-Kinase Inhibitor X, CX-6258 - Calbiochem Chemical Properties,Uses,Production
General Description
An orally bioavailable oxindolo-furanyl compound that acts as a potent, reversible and ATP-competitive inhibitor of pan PIM-kinases (IC50 = 5, 25 and 16 nM for PIM-1, PIM-2 and PIM-3, respectively; Ki = 5 nM for PIM-1) with excellent selectivity over 107 kinases (IC80 >500 nM). Shown to arrest the proliferation of several human cancer cells (IC50 = 20 and 452 nM for MV-4-11 and PC3 cells) and block phosphorylation of Bad-Ser112, 4E-BP1-Ser65 and Thr37/46 with an IC50 of ~ 1.0 μM. Displays favorable pharmacokinetic profile and efficacy in mice, and suppresses tumor growth in MV-4-11 and PC3 xenograft murine model (50 mg/kg, p.o.). Further, potentiates doxorubicin (Cat. No. 324380) and paclitaxel (Cat. No. 580555) toxicity in PC3 cells.
Biochem/physiol Actions
Cell permeable: yes
PIM-Kinase Inhibitor X, CX-6258 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
PIM-Kinase Inhibitor X, CX-6258 - Calbiochem Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |