ChemicalBook >> CAS DataBase List >>3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone structure

CAS No.: 272778-12-8

Chemical Name:: 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone

Synonyms: ZT-6;]-oxy]phenyL;y)-oxy]pentyL;-(4S)-2-oxazoL;)-2-[(S)-[(4-fL;Ezetimibe INT 1;Ezetimibe inter-X;3-[(2R,5S)-5-(4-FL;Ezetimibe Impurity 9;Ezetimibe Impuriry 9

CBNumber:: CB8482499

Molecular Formula:: C39H46F2N2O5Si2

Molecular Weight:: 716.96

MDL Number:: MFCD08460200

MOL File:: 272778-12-8.mol

Last updated:2023-12-21 17:48:05

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3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Properties

Melting point	190-200°C
Boiling point	748.9±60.0 °C(Predicted)
Density	1.177
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform, Ethyl Acetate, Methanol
form	Solid
pka	3.55±0.50(Predicted)
color	White to Off-White
LogP	10.28 at 21℃
FDA UNII	MY62DF4M9J

SAFETY

Risk and Safety Statements

Hazard statements	H413

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F598440	(4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone	272778-12-8	25mg	$150	2021-12-16	Buy
TRC	F598440	(4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone	272778-12-8	250mg	$1190	2021-12-16	Buy
Medical Isotopes, Inc.	51437	(4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone	272778-12-8	25mg	$650	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0000643	2-OXAZOLIDINONE, 3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL)AMINO][4-[(TRIMETHYLSILYL)OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILYL)OXY]PENTYL]-4-PHENYL-, (4S)- 95.00%	272778-12-8	5G	$909.56	2021-12-16	Buy
Chemenu	CM137902	2-Oxazolidinone,3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-,(4S)- 95%	272778-12-8	5g	$224	2021-12-16	Buy

Product number	Packaging	Price	Buy
F598440	25mg	$150	Buy
F598440	250mg	$1190	Buy
51437	25mg	$650	Buy
ORS0000643	5G	$909.56	Buy
CM137902	5g	$224	Buy

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Chemical Properties,Uses,Production

Chemical Properties

Off-white Solid

Uses

(4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is an intermediate in the preparat ion of Ezetimibe (E975000).

Uses

(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Suppliers

Global( 192)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	986	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2966	58
Casorganics US Corp	+17326109938	sales@casorganics.com	CHINA	174	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
Sinoway Industrial co., ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Casorganics US Corp	58
Standardpharm Co. Ltd.	58
BOC Sciences	58

View Lastest Price from 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-10	3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone 272778-12-8	US $185.00-85.00 / Kg/Bag	1Kg/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.
2021-12-22	3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone 272778-12-8	US $10.00 / KG	1KG	98%	500ton/Month	Qiuxian Baitai New Material Co., LTD
2021-08-13	3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone USP/EP/BP 272778-12-8	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone
272778-12-8
US $185.00-85.00 / Kg/Bag
99% up, High Density
Sinoway Industrial co., ltd.

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone
272778-12-8
US $10.00 / KG
98%
Qiuxian Baitai New Material Co., LTD

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone USP/EP/BP
272778-12-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

272778-12-8(3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone)Related Search:

1,5-Pentanedione, 1,5-bis(4-fluorophenyl)- Tris(hydroxymethyl)aminomethane Methyltriphenylphosphonium bromide Dichloromethylphenylsilane Betaine

Trimethylphenylammonium chloride EC 2.6.1.2 N,N-Dimethyl-1,4-phenylenediamine Glycine Lithium bis(trimethylsilyl)amide

Acetaminophen ALTRENOGEST Ezetimibe EzetiMibe LactaM Cleaved Alcohol 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone

5-(4-FLUOROPHENYL)VALERIC ACID ent-EzetiMibe EzetiMibe (3R,4R,3'S)-IsoMer

1of4

E3:3-[(2R,5S)-5-(4-fluorophenyl)-2-{(S)-[(4-fluorophenyl)Amino]}[4-(trimethylsilyl)-oxy]pentyl]methyl-1-2oxo-5-( trimethylsilyl)-oxo]penyl]-4-phenyl-(4S)-2-oxazolidinone (S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)aMino)(4-((triMethylsilyl)oxy)phenyl)Methyl)-5-((triMethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one 2-OXAZOLIDINONE,3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL)AMINO][4-[(TRIMETHYLSILYL)OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILYL)OXY]PENTYL]-4-PHENYL-,(4S)- 3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL(AMINO)]] [4-[TRIMETHYLSILYL]-OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILY)-OXY]PENTYL]-4-PHENYL-(4S)-2-OXAZOLIDINONE 2-OXAZOLIDINONE, 3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL)AMINO][4-[(TRIMETHYLSILYL)OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILYL)OXY]PENTYL]-4-PHENYL-, (4S)- 3-[(2r,5s)-5-(4-Fluorophenyl)-2-[(S)-[(4-Fluorophenyl( Amino)]][4-[Trimethylsilyl]-Oxy]Phenyl]Methyl]-1-Oxo-5-[(Trimethylsilyl)-Oxy]Pentyl]-4-Phenyl-(4s)-2-Oxazolidinone 3-[(2R,5S)-5-(4-fluorophenyl)-2-{(S)-[4-fluorophenyl]Amino}[4-(trimethylsily)-oxy]pentyl]methyl-1-2oxo-5-(trimethylsilyl)-oxo]penyl]-4-phenyl-(4S)-2-oxazolidinone 3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL( AMINO)]] [4-[TRIMETHYLSILYL]-OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILY) -OXY]PENTYL]-4-PHENYL-(4S)- 2-OXAZOLIDINONE(INTERMEDIATE OF EZETIMIBE) INTERMEDIATE OF EZETIMIBE 3-(2R,5S)-5-(4-fluorophenyl)-2-(S)-(4-fluorophenyl(amino)4-trimethylsilyl-oxyphenylmethyl-1-oxo-5-(trimethylsily)-oxypentyl-4-phenyl-(4S)-2-oxazolidinone (4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone Ezetimibe Impurity 9 ZT-6 Ezetimibe Intermediate X (4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]meth Ezetimibe inter-X 3-[(2R,5S)-5-(4-fluorophenyl)-2-{(S)-[4-fluorophenyl]Amino}[4-(trimethylsily)-oxy]pentyl]methyl-1-2oxo-5-(trimethylsilyl)-oxo]penyl]-4-phenyl-(4S)-2-oxazolidinon 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S (4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]-(4-trimethylsilyloxyphen yl)methyl]-5-trimethylsilyloxy-pentanoyl]-4-phenyl-1,3-oxazolidin-2-one Ezetimibe Impurity 68 3-[2-[(4-fluoroanilino)-(4-trimethylsilyloxyphenyl)methyl]-5-(4-fluorophenyl)-1-oxo-5-trimethylsilyloxypentyl]-4-phenyl-2-oxazolidinone -(4S)-2-oxazoL (amino)]][4-[trimethyL )-2-[(S)-[(4-fL ]-1-oxo-5-[(trimethyL 3-[(2R,5S)-5-(4-FL y)-oxy]pentyL ]-oxy]phenyL Ezetimibe INT 1 Ezetimibe Impurity 68 USP/EP/BP 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone USP/EP/BP 4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]- oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)... Ezetimibe Impuriry 9 3-[(2R,5S)-5-(4- fluorophenyl) -2-[(S)-[(4- fluorophenyl (amino) ]][4- (trimethylsilyl) oxy] phenyl] methyl ]-1- oxo -5-[ (trimethylsilyl) oxy] phenyl {2-[3-(Fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4- fluoro phenyl amino) -3-(4-trimethyl silyloxy phenyl)-1- oxo-propyl}-4-(S) phenyl oxazolidin-2-one Ezetimibe TMS intermediate 3-((2R,5S)-5-(4-fluorophenyl)-2-(S)-((4-fluorophenyl)amino)(4-((trimethylsilyl)oxy)phenyl)methyl)-1-((trimethylsilyl)oxy)pentyl)-4-phenyl-(4S)-2-oxazolidinone 3-{(2R,5S)-5-(4-Fluoro-phenyl)-2-[(S)-(4-fluoro-phenylamino)-(4-trimethylsilanyloxy-phenyl)-methyl]-5-trimethylsilanyloxy-pentanoyl}-4(S)-phenyl-oxazolidin-2-one 272778-12-8 C39H46F2N2O5Si2 Ezetimibe intermediates Ezetimibe pharmaceutical