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(S,R,S)-AHPC-PEG3-Alkyne

CAS No.
2374122-30-0
Chemical Name:
(S,R,S)-AHPC-PEG3-Alkyne
Synonyms
(S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-PEG?-Alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber:
CB84846305
Molecular Formula:
C32H44N4O7S
Molecular Weight:
628.79
MDL Number:
MFCD32173788
MOL File:
2374122-30-0.mol
MSDS File:
SDS
Last updated:2024-04-01 13:48:23

(S,R,S)-AHPC-PEG3-Alkyne Properties

Boiling point 881.7±65.0 °C(Predicted)
Density 1.224±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 14.07±0.40(Predicted)

(S,R,S)-AHPC-PEG3-Alkyne price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 901533 (S,R,S)-AHPC-PEG3-Alkyne ≥95% 2374122-30-0 50MG $632 2023-06-20 Buy
Iris Biotech GmbH PTC1480 (S,R,S)-AHPC-PEG3-Alkyne 2374122-30-0 50mg $648 2021-12-16 Buy
Product number Packaging Price Buy
901533 50MG $632 Buy
PTC1480 50mg $648 Buy

(S,R,S)-AHPC-PEG3-Alkyne Chemical Properties,Uses,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-PEG3-Alkyne Preparation Products And Raw materials

Raw materials

Preparation Products

(S,R,S)-AHPC-PEG3-Alkyne Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
Xian confluore Biological Technology Co., Ltd.
+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8014 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9943 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4824 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1383 58
Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725 malulu@leyan.com China 54986 58
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 2853979819@qq.com China 9530 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58

View Lastest Price from (S,R,S)-AHPC-PEG3-Alkyne manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-PEG3-Alkyne pictures 2024-04-02 (S,R,S)-AHPC-PEG3-Alkyne
2374122-30-0
US $0.00 / mg 100mg >99.00% 100mg Xian confluore Biological Technology Co., Ltd.
(S,R,S)-AHPC-PEG3-Alkyne (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (S,R,S)-AHPC-PEG?-Alkyne (2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide 2374122-30-0