ChemicalBook >> CAS DataBase List >>(S,R,S)-AHPC-PEG3-Alkyne
(S,R,S)-AHPC-PEG3-Alkyne
- CAS No.
- 2374122-30-0
- Chemical Name:
- (S,R,S)-AHPC-PEG3-Alkyne
- Synonyms
- (S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-PEG?-Alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber:
- CB84846305
- Molecular Formula:
- C32H44N4O7S
- Molecular Weight:
- 628.79
- MDL Number:
- MFCD32173788
- MOL File:
- 2374122-30-0.mol
- MSDS File:
- SDS
Last updated:2024-04-01 13:48:23
(S,R,S)-AHPC-PEG3-Alkyne Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
(S,R,S)-AHPC-PEG3-Alkyne Preparation Products And Raw materials
Raw materials
Preparation Products
(S,R,S)-AHPC-PEG3-Alkyne Suppliers
Global( 14)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9943 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1383 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 54986 | 58 |
| Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9530 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
View Lastest Price from (S,R,S)-AHPC-PEG3-Alkyne manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-04-02 | (S,R,S)-AHPC-PEG3-Alkyne
2374122-30-0
|
US $0.00 / mg | 100mg | >99.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
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- (S,R,S)-AHPC-PEG3-Alkyne
2374122-30-0
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.
(S,R,S)-AHPC-PEG3-Alkyne
(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(S,R,S)-AHPC-PEG?-Alkyne
(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
2374122-30-0