ALPHA-ZEARALENOL
- CAS No.
- 36455-72-8
- Chemical Name:
- ALPHA-ZEARALENOL
- Synonyms
- ZEARALENOL;Α-ZEARALENOL;A-ZEARALENOL;(3S,7R,11E)-;α-Zearalenol;alfa-Zearalenol;ALPHA-ZEARALENOL;trans-α-Zearalenol;Zearalenol, alpha-;α-Zearalenol solution
- CBNumber:
- CB8491950
- Molecular Formula:
- C18H24O5
- Molecular Weight:
- 320.38
- MDL Number:
- MFCD16657008
- MOL File:
- 36455-72-8.mol
| Melting point | 158-161°C |
|---|---|
| Boiling point | 599.0±50.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | -20°C |
| solubility | ≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 7.61±0.60(Predicted) |
| Stability | Hygroscopic |
| FDA UNII | 59D4EVJ5KC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H351-H361fd-H371-H412 | |||||||||
| Precautionary statements | P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45 | |||||||||
| Safety Statements | 36/37-61-16-45-53 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8 | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
ALPHA-ZEARALENOL price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z0166 | α-Zearalenol | 36455-72-8 | 5mg | $384 | 2024-03-01 | Buy |
| Sigma-Aldrich | 35406 | α-Zearalenol solution 10 μg/mL in acetonitrile, analytical standard | 36455-72-8 | 1ml | $835 | 2024-03-01 | Buy |
| Cayman Chemical | 16549 | α-Zearalenol ≥98% | 36455-72-8 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 16549 | α-Zearalenol ≥98% | 36455-72-8 | 5mg | $286 | 2024-03-01 | Buy |
| Sigma-Aldrich | Z0166 | α-Zearalenol | 36455-72-8 | 10mg | $424.2 | 2024-03-01 | Buy |
ALPHA-ZEARALENOL Chemical Properties,Uses,Production
Description
α-Zearalenol is a major hepatic metabolite of zearalenone , a mycotoxin produced by fungi in food and animal feeds. It is a less potent agonist of estrogen receptors than the parent compound. However, α-zearalenol has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.
Chemical Properties
Off-White Solid
Uses
The major metabolites of Zearalenone
Uses
α- Zearalenol may be used as an analytical reference standard for the determination of the analyte in traditional medicinal herbs, human and animal urine by various chromatography techniques.
Uses
α-Zearalenol is a mycotoxin produced by several species of Fusarium. α-Zearalenol exhibits pronounced estrogenic activity, being 3-fold more active than zearalenone. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenol and is regarded as an important food quality issue for both humans and animal health.
Definition
ChEBI: Alpha-Zearalenol is a macrolide.
Biochem/physiol Actions
α-Zearalenol (α-ZOL) is a catabolite of zearalenone, synthesized majorly in granulosa cells, intestine and liver in pigs. It has estrogenic functionality. α-ZOL inhibits sperm motility in horse possibly by eliciting genotoxic effect. α-ZOL displays higher affinity towards estrogenic receptors.
in vitro
the binding characteristic of α-zea was less potent with estrogen receptors than the parent compound [2]. α-zearalenol showed pronounced effects on uterotropic activity [3]. α-zea inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction [4].
References
[1]. zinedine a, soriano j m, molto j c, et al. review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin[j]. food and chemical toxicology, 2007, 45(1): 1-18.
[2]. kiang d t, kennedy b j, pathre s v, et al. binding characteristics of zearalenone analogs to estrogen receptors[j]. cancer research, 1978, 38(11 part 1): 3611-3615.
[3]. mirocha c j, pathre s v, behrens j, et al. uterotropic activity of cis and trans isomers of zearalenone and zearalenol[j]. applied and environmental microbiology, 1978, 35(5): 986-987.
[4]. filannino a, stout t a e, gadella b m, et al. dose-response effects of estrogenic mycotoxins (zearalenone, alpha-and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm[j]. reproductive biology and endocrinology, 2011, 9(1): 134.
ALPHA-ZEARALENOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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