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STREPTOKINASE

CAS No.
9002-01-1
Chemical Name:
STREPTOKINASE
Synonyms
SK;awelysin;streptase;kabikinase;Dickkopf-1;DKK-1 human;STREPTOKINASE;Plasminokinase;Crude Streptokinase;4-Cyclohexylproline
CBNumber:
CB8492124
Molecular Formula:
C11H19NO2
Molecular Weight:
197.27406
MDL Number:
MFCD00082037
MOL File:
9002-01-1.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

STREPTOKINASE Properties

storage temp. -20°C
form lyophilized powder
color White to off-white
biological source human
Merck 13,8903
Specific Activity ≥2,000units/mg solid
EWG's Food Scores 1
FDA UNII VJ8EI98212
ATC code B01AD01,B06AA55
UNSPSC Code 12352204
NACRES NA.54

Pharmacokinetic data

Volume of distribution 0.02-0.08(L/kg)
Biological half-life 18 minutes / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P305+P351+P338
Hazard Codes  B,Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  OB8880000
10-21
HS Code  3504009000
Toxicity LD50 oral in mouse: > 10gm/kg

STREPTOKINASE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S3134 Streptokinase from β-hemolytic Streptococcus (Lancefield Group C) lyophilized powder, ≥2,000?units/mg solid 9002-01-1 10000units $63.9 2024-03-01 Buy
Sigma-Aldrich S3134 Streptokinase from β-hemolytic Streptococcus (Lancefield Group C) lyophilized powder, ≥2,000?units/mg solid 9002-01-1 50000units $206 2024-03-01 Buy
Sigma-Aldrich S3134 Streptokinase from β-hemolytic Streptococcus (Lancefield Group C) lyophilized powder, ≥2,000?units/mg solid 9002-01-1 250000units $702 2024-03-01 Buy
Sigma-Aldrich SRP6211 DKK-1 human recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE) 9002-01-1 10μg $332 2023-01-07 Buy
Sigma-Aldrich SRP6211 DKK-1 human recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE) 9002-01-1 50μg $1590 2023-01-07 Buy
Product number Packaging Price Buy
S3134 10000units $63.9 Buy
S3134 50000units $206 Buy
S3134 250000units $702 Buy
SRP6211 10μg $332 Buy
SRP6211 50μg $1590 Buy

STREPTOKINASE Chemical Properties,Uses,Production

Description

Streptokinase is a protein produced by certain strains of hemolytic group C streptococcus, and it was the first clinically useful fibrinolytic. Unlike other plasminogen activators, streptokinase is not an enzyme and cannot break any bonds in a plasminogen molecule by itself. It forms an equimolecular compound with plasminogen, thus forming a streptokinase–plasminogen complex. In the plasminogenic region of the resulting complex, certain conformational changes lead to a break in a few peptide bonds, and transformation of this complex into a streptokinase–plasmin complex, or free plasmin, which also decomposes fibrin.

Originator

Streptase,Hoechst,France,1970

Uses

This drug has a half-life in the plasma of 15–30 min, and is used intravenously to treat patients with severe, massive pulmonary embolism and thrombus of the veins; it is also used during myocardial infarctions. Recently, a number of streptokinase derivatives have been proposed, in particular acetylated derivatives, which are developed for use as fibrinolytics.

Uses

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare. Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Therapeutic Function

Enzyme

General Description

Streptokinase (Kabikinase, Streptase)is a catabolic 47,000-d protein secreted by group Cβ-hemolyticstreptococci. It is a protein with no intrinsic enzymaticactivity. Streptokinase activates plasminogen toplasmin, a proteolytic enzyme that hydrolyzes fibrin andpromotes the dissolution of thrombi. Plasminogen is activatedwhen streptokinase forms a 1:1 stoichiometric complexwith it. Allergic reactions to streptokinase occur commonlybecause of antibody formation in individuals treatedwith it. Furthermore, the antibodies inactivate streptokinaseand reduce its ability to prolong thrombin time.Streptokinase is indicated for acute myocardial infarction,for local perfusion of an occluded vessel, and before angiography,by intravenous, intra-arterial, and intracoronaryadministration, respectively.

Biochem/physiol Actions

DKK1 (dickkopf WNT signaling pathway inhibitor 1) functions as a pure inhibitor of Wnt signaling, and was identified as an essential factor for head induction during early Xenopus embryogenesis by suppressing Wnt signaling. In skin, this protein plays a role in determining the pigmentation pattern of the human hand. In colon cancer cells, this protein is inactivated by CpG island promoter hypermethylation. Mesenchymal stem cells (MSCs) have an anti-proliferative effect on cancer cells, as they secrete DKK1 which blocks Wnt signaling.

Mechanism of action

Streptokinase is a protein purified from culture broths of group C β-hemolytic streptococci bacteria. Streptokinase contains a single polypeptide chain of 414-amino-acid residues with a molecular weight of 47 kDa. Streptokinase by itself has no intrinsic enzymatic activity. To be active, it must bind with plasminogen to form an activator complex (1:1 complex). This complex then acts to convert uncomplexed plasminogen to the active fibrinolytic enzyme, plasmin. The streptokinase/plasminogen complex not only degrades fibrin clots but also catalyzes the breakdown of fibrinogen and factors V and VII. As a result, streptokinase is considered to be a fibrinnonspecific drug.

Pharmacokinetics

Unfortunately, the half-life of the activator complex is less than 30 minutes, which frequently is too short to completely lyse a thrombus. Anistreplase (APSAC; Eminase) is a 1:1 streptokinase/lysineplasminogen complex that has been acylated with an anisoyl group at the active-site serine within the lysine-plasminogen. Anistreplase is inactive as such, but following complexation with fibrin, the anisoyl group is slowly cleaved, exposing the active site and, thus, leading to degradation of fibrin. The pro-drug nature of anistreplase exhibits an improved pharmacokinetic profile, with anistreplase acting as a semiselective lysis agent at the clot site. The inactivity of the circulating anistreplase also allows this drug to be given as a very rapid intravenous infusion (typically, 30 U over 3–5 minutes). Tissue reperfusion following anistreplase therapy compares favorably to streptokinase because of the extended half-life (90 minutes).

Clinical Use

Fibrinolytic:
Thrombolysis in DVT, PE, acute arterial thromboembolism, acute MI, thrombosed A-V shunts

Side effects

Because it is a foreign protein, streptokinase is associated with significant hypersensitivity reactions. Most people have, at some point in their lives, had a streptococcal infection and, therefore, have developed circulating antistreptococcal antibodies. These antibodies frequently are active against streptokinase as well. The response of the streptokinase to these antibodies can vary widely, from inactivation of the fibrinolytic properties of the protein to rash, fever, and rarely, anaphylaxis. Significant allergic reactions to streptokinase occur in approximately 3% of patients.

Veterinary Drugs and Treatments

Streptokinase may be useful for the adjunctive treatment of serious thromboses. The use of thrombolytics (streptokinase, t-PA) in cats is controversial.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants should not be given with streptokinase.
Heparin infusions should be stopped 4 hours before streptokinase infusion. If this is not possible, protamine sulphate should be used to neutralise the heparin; heparin infusions can be restarted 4 hours post streptokinase infusion followed by oral anticoagulants.

Metabolism

A small proportion of the dose is bound to antistreptokinase antibodies and metabolised with a half-life of 18 minutes, whilst most of it forms the streptokinaseplasminogen activator complex and is biotransformed with a half-life of about 80 minutes.

STREPTOKINASE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22787 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15352 58
Wuhan Fortuna Chemical Co.,Ltd
+8618007136271 hk@fortunachem.com China 5998 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
+8618950047208 ellena@amitychem.com China 43416 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
Adamas Reagent, Ltd. 400-6009262 16621234537 chenyj@titansci.com China 14103 59
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2123 70
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9895 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12335 58

View Lastest Price from STREPTOKINASE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
STREPTOKINASE pictures 2024-08-30 STREPTOKINASE
9002-01-1
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
  • STREPTOKINASE pictures
  • STREPTOKINASE
    9002-01-1
  • US $0.10 / KG
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd
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