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O-Desmethylvenlafaxine

O-Desmethylvenlafaxine
O-Desmethylvenlafaxine structure
CAS No.
93413-62-8
Chemical Name:
O-Desmethylvenlafaxine
Synonyms
DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;DL-O-Desmethylvenlafaxin;Desvenlafaxine impurity C;O-Desmethylvenlafaxine(DL)
CBNumber:
CB8496834
Molecular Formula:
C16H25NO2
Formula Weight:
263.38
MOL File:
93413-62-8.mol

O-Desmethylvenlafaxine Properties

Melting point:
208-213°C
Boiling point:
403.8±25.0 °C(Predicted)
Density 
1.115±0.06 g/cm3(Predicted)
Flash point:
9℃
storage temp. 
2-8°C
form 
neat
pka
10.04±0.26(Predicted)
InChIKey
KYYIDSXMWOZKMP-UHFFFAOYSA-N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08,GHS07
Signal word  Danger
Hazard statements  H319-H225-H301+H311+H331-H370
Precautionary statements  P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P260-P301+P310-P311-P305+P351+P338
Hazard Codes  F,T,Xi
Risk Statements  11-23/24/25-39/23/24/25-36
Safety Statements  7-16-36/37-45-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  GV8872620
HS Code  29225090

O-Desmethylvenlafaxine price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V-007 O-Desmethylvenlafaxine solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material 93413-62-8 007-1ml $73 2020-08-18 Buy
Sigma-Aldrich V-007 O-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 93413-62-8 1 mL $75.3 2021-03-22 Buy
Sigma-Aldrich V-045 O-Desmethylvenlafaxine 1.0 mg/mL in methanol, certified reference material 93413-62-8 045-1ml $327 2020-08-18 Buy
Sigma-Aldrich V-045 O-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant? 93413-62-8 1 mL $337 2021-03-22 Buy
TCI Chemical D5598 O-Desmethylvenlafaxine 93413-62-8 1G $41 2021-03-22 Buy

O-Desmethylvenlafaxine Chemical Properties,Uses,Production

Description

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50=47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

Chemical Properties

White Solid

Originator

Wyeth (United States)

Uses

A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Uses

A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.

Uses

a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.

Definition

ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.

brand name

Pristiq

Chemical Synthesis

Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.

O-Desmethylvenlafaxine Preparation Products And Raw materials

Raw materials

Preparation Products


O-Desmethylvenlafaxine Suppliers

Global( 149)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58

View Lastest Price from O-Desmethylvenlafaxine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 O-Desmethylvenlafaxine
93413-62-8
US $0.00-0.00 / KG 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
2019-07-06 O-Desmethylvenlafaxine
93413-62-8
US $2.00 / kg 1kg 99% 100kg career henan chemical co

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