ChemicalBook >> CAS DataBase List >>O-Desmethylvenlafaxine

O-Desmethylvenlafaxine

CAS No.
93413-62-8
Chemical Name:
O-Desmethylvenlafaxine
Synonyms
DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36;Venlafaxine O-Desmethyl
CBNumber:
CB8496834
Molecular Formula:
C16H25NO2
Molecular Weight:
263.38
MDL Number:
MFCD00871934
MOL File:
93413-62-8.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:07

O-Desmethylvenlafaxine Properties

Melting point 208-213°C
Boiling point 403.8±25.0 °C(Predicted)
Density 1.115±0.06 g/cm3(Predicted)
Flash point 9℃
storage temp. 2-8°C
solubility insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
pka 10.04±0.26(Predicted)
InChIKey KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP 0.33 at 25℃ and pH6
FDA UNII NG99554ANW
ATC code N06AX23

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  F,T,Xi
Risk Statements  11-23/24/25-39/23/24/25-36
Safety Statements  7-16-36/37-45-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  GV8872620
HS Code  29225090
NFPA 704
0
2 0

O-Desmethylvenlafaxine price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V-045 O-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant? 93413-62-8 1mL $428 2024-03-01 Buy
Sigma-Aldrich V-007 O-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 93413-62-8 1mL $95.5 2024-03-01 Buy
TCI Chemical D5598 O-Desmethylvenlafaxine 93413-62-8 1G $111 2024-03-01 Buy
TCI Chemical D5598 O-Desmethylvenlafaxine 93413-62-8 5G $334 2024-03-01 Buy
Cayman Chemical 9001881 (±)-O-Desmethyl Venlafaxine ≥98% 93413-62-8 5mg $72 2024-03-01 Buy
Product number Packaging Price Buy
V-045 1mL $428 Buy
V-007 1mL $95.5 Buy
D5598 1G $111 Buy
D5598 5G $334 Buy
9001881 5mg $72 Buy

O-Desmethylvenlafaxine Chemical Properties,Uses,Production

Description

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50=47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

Chemical Properties

White Solid

Originator

Wyeth (United States)

Uses

A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Uses

a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.

Uses

A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.

Definition

ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.

brand name

Pristiq

General Description

An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.

Synthesis

Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.

93413-69-5
93413-62-8
Synthesis of O-Desmethylvenlafaxine from Venlafaxine
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Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58

View Lastest Price from O-Desmethylvenlafaxine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
O-Desmethylvenlafaxine pictures 2021-07-20 O-Desmethylvenlafaxine
93413-62-8
US $0.00-0.00 / KG 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
O-Desmethylvenlafaxine pictures 2019-07-06 O-Desmethylvenlafaxine
93413-62-8
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

O-Desmethylvenlafaxine Spectrum

O-DESMETHYL VENLAFAXINE-D10 DL-O-Desmethylvenlafaxin 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol O-Desmethylvenlafaxine Desvenlafaxine(O-Desnethylvenfaxine) 1-[1-(4-Hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol 4-[1-(1-Hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol Desmethylvenlafaxine Wy-45233 O-desMethylvenlafaxin DVS 233 desvenlafaxine O-DesMethyl Venlafaxine Hydrochloride Venlafaxine O-DesMethyl IMpurity Desvenlafaxine (O-DesMethyl venlafaxine) Phenol,4-[2-(diMethylaMino)-1-(1-hydroxycyclohexyl)ethyl]- Desvenlafaxine Base O-Desmethylvenlafaxine solution O-Desmethylvenlafaxine(DL) Desvenlafaxine impurity C Venlafaxine-d10 HCl O-Desmethyl Venlafaxine-d10 O-Desmethylvenlafaxine, 98%, a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor D,L-O-Desmethyl Venlafaxine (100 μg/mL in Methanol) O-Desmethylvenlafaxine USP/EP/BP Desvenlafaxine (WY 45233 Venlafaxine Impurity 36 DesvenlafaxineQ: What is Desvenlafaxine Q: What is the CAS Number of Desvenlafaxine Q: What is the storage condition of Desvenlafaxine Q: What are the applications of Desvenlafaxine 93413-62-8 O-Desmethylvenlafaxine Venlafxine-O-Desmethyl Venlafaxine O-Desmethyl O-Desmethyl Venlafaxine (Free base) 93413-62-8 96413-62-8 PRISTIQ Metabolite & impurity Metabolites Intermediates & Fine Chemica Pfizer Compounds Amines Aromatics Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals