GANAXOLONE
- CAS No.
- 38398-32-2
- Chemical Name:
- GANAXOLONE
- Synonyms
- Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone;1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
- CBNumber:
- CB8498146
- Molecular Formula:
- C22H36O2
- Molecular Weight:
- 332.52
- MDL Number:
- MFCD09971088
- MOL File:
- 38398-32-2.mol
- MSDS File:
- SDS
| Melting point | 190-192° |
|---|---|
| alpha | D +103° |
| Boiling point | 434.8±18.0 °C(Predicted) |
| Density | 1.036±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ~4.2 mg/mL |
| form | solid |
| pka | 15.18±0.70(Predicted) |
| color | white |
| FDA UNII | 98WI44OHIQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | TU4384700 |
GANAXOLONE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G7795 | Ganaxolone solid | 38398-32-2 | 5mg | $196 | 2024-03-01 | Buy |
| Sigma-Aldrich | G7795 | Ganaxolone solid | 38398-32-2 | 25mg | $677 | 2024-03-01 | Buy |
| Cayman Chemical | 20919 | Ganaxolone ≥98% | 38398-32-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20919 | Ganaxolone ≥98% | 38398-32-2 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 20919 | Ganaxolone ≥98% | 38398-32-2 | 10mg | $153 | 2024-03-01 | Buy |
GANAXOLONE Chemical Properties,Uses,Production
Description
Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.
Uses
Treatment of epilepsy and migraine.
Uses
Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.
Definition
ChEBI: Ganaxolone is a corticosteroid hormone.
Biological Activity
Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
Biochem/physiol Actions
Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.
storage
+4°C
GANAXOLONE Preparation Products And Raw materials
GANAXOLONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hunan Yuanye Pharmaceutical Co., Ltd. | +8615857615745 | 2675013845@qq.com | China | 87 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Hunan Yuanye Pharmaceutical Co., Ltd. | 0731-85589467; 13574065797 | 2675013845@qq.com | China | 33 | 58 |
| Bayee Biotech (Anqing) Co., Ltd. | 0556-5032306 18917961636 | wtx@bayeebio.com | China | 253 | 61 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from GANAXOLONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | GANAXOLONE
38398-32-2
|
US $0.01 / KG | 1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
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- GANAXOLONE
38398-32-2
- US $0.01 / KG
- 98%; 99%
- Career Henan Chemical Co