DMT-2′Fluoro-dU Phosphoramidite
- CAS No.
- 146954-75-8
- Chemical Name:
- DMT-2′Fluoro-dU Phosphoramidite
- Synonyms
- 2‘-F-U amidite;2'-Fluoro-dU CEP;2’-F-dU Amidite;2’-F-rUPhosphoramidite;2'-F-U Phosphoramidite;2'-F-dU Phosphoramidite;5'-O-DMT-2'-fluoro-dU-CE;5'-O-DMT-2'-F-dU-3'-CEDPA;2'-Fluoro Uridine Amidite;DMT-2'-F-U Phosphoramidite
- CBNumber:
- CB8500324
- Molecular Formula:
- C39H46FN4O8P
- Molecular Weight:
- 748.78
- MDL Number:
- MFCD11113919
- MOL File:
- 146954-75-8.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| form | powder |
| pka | 9.39±0.10(Predicted) |
| color | white to off-white |
| InChIKey | HQHQPAYRJJMYQX-YOKGOYKLNA-N |
| SMILES | N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r| |
DMT-2′Fluoro-dU Phosphoramidite price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | U211280 | DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen | 146954-75-8 | 1G | $206 | 2024-03-01 | Buy |
| Sigma-Aldrich | U211250 | DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA? and OligoPilot?) | 146954-75-8 | 1G | $219 | 2024-03-01 | Buy |
| Sigma-Aldrich | U211200 | DMT-2′Fluoro-dU Phosphoramidite ≥99% (31P-NMR) | 146954-75-8 | 100g | $8200 | 2024-03-01 | Buy |
| Sigma-Aldrich | U211200 | DMT-2′Fluoro-dU Phosphoramidite ≥99% (31P-NMR) | 146954-75-8 | 500g | $36650 | 2024-03-01 | Buy |
| Sigma-Aldrich | U211280 | DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen | 146954-75-8 | 2g | $383 | 2024-03-01 | Buy |
DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Uses,Production
Uses
5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.
Definition
DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA
Synthesis
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).
DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
DMT-2′Fluoro-dU Phosphoramidite Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Allbiosyn Biotechnology Co.,Ltd. | +8618666985712 | info@allbiosyn.com | China | 286 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18632 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
View Lastest Price from DMT-2′Fluoro-dU Phosphoramidite manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-08 | 5'-O-DMT-2'-fluoro-dU-CE
146954-75-8
|
US $0.00 / mg | 100mg | ≥99% | 20tons | Hefei Huana Biomedical Technology Co.,Ltd. | |
 |
2024-02-13 | 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit
146954-75-8
|
US $1550.00 / g | 1g | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2023-04-04 | DMT-2′Fluoro-dU Phosphoramidite
146954-75-8
|
US $0.00-0.00 / kg | 1kg | 98% | 500kg per month | Zhejiang Hengkang Pharmaceutical Co., Ltd. |
-
- 5'-O-DMT-2'-fluoro-dU-CE
146954-75-8
- US $0.00 / mg
- ≥99%
- Hefei Huana Biomedical Technology Co.,Ltd.
-
- 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit
146954-75-8
- US $1550.00 / g
- 98
- R&D Scientific Inc.
-
- DMT-2′Fluoro-dU Phosphoramidite
146954-75-8
- US $0.00-0.00 / kg
- 98%
- Zhejiang Hengkang Pharmaceutical Co., Ltd.
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