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Tocainide hydrochloride

Tocainide hydrochloride
Tocainide hydrochloride structure
CAS No.
35891-93-1
Chemical Name:
Tocainide hydrochloride
Synonyms
Xylotocan;TOCAINIDE HCL;Unii-2K7I38ckn5;tonocardhydrochloride;tocainide hydrochloride;TOCAINIDE HYDROCHLORIDE (125 MG);2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride;2-amino-n-(2,6-dimethylphenyl)-propanamidmonohydrochloride;2-amino-n-(2,6-dimethylphenyl)propanamidemonohydrochloride;Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, monohydrochloride
CBNumber:
CB8500546
Molecular Formula:
C11H17ClN2O
Formula Weight:
228.71848
MOL File:
35891-93-1.mol
SAFETY
  • Risk and Safety Statements
HS Code  2924296000

Tocainide hydrochloride Chemical Properties,Uses,Production

Uses

Tonocard(AstraZeneca).

General Description

Tocainide hydrochloride,2-amino-2' ,6 '-propionoxyxylidide hydrochloride (Tonocard)(pKa 7.7), is an analog of lidocaine. It is orally active and haselectrophysiological properties like those of lidocaine. Totalbody clearance of tocainide hydrochloride is only166 mL/min, suggesting that hepatic clearance is not large.Because of low hepatic clearance, the hepatic extraction ratiomust be small; therefore, tocainide hydrochloride is unlikelyto be subject to a substantial first-pass effect. The drug differsfrom lidocaine, in that it lacks two ethyl groups, which providestocainide hydrochloride some protection from first-passhepatic elimination after oral ingestion. Tocainide hydrochlorideis hydrolyzed in a manner similar to that of lidocaine.None of its metabolites is active.

Clinical Use

Tocainide hydrochloride is classed as a IB antiarrhythmicagent and used orally to prevent or treat ventricular ectopyand tachycardia. The drug is given in 400- to 600-mgdoses every 8 hours.

Veterinary Drugs and Treatments

Veterinary experience with tocainide is limited. At this time, dogs are the only veterinary species where enough clinical experience has been garnered to recommend its use. It is indicated for the oral therapy of ventricular arrhythmias, principally ventricular tachycardia and ventricular premature complexes. In humans, response to lidocaine can usually predict whether tocainide might be effective.

Tocainide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Tocainide hydrochloride Suppliers

Global( 13)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9847 79
Boen pharm 86 512-62572107 62962707
86 512-62922078 sales@boenpharm.com China 800 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-56371250
010-56371282 2748554845@qq.com China 13776 68

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