SU 5416
- CAS No.
- 204005-46-9
- Chemical Name:
- SU 5416
- Synonyms
- 17022;SU54161;SeMaxinib;(Z)-3-((3;Sugen 5416;SU5416 /SU-5416;SU 5416 semaxanib;SEMAXINIB(SU 5416);SU 5416 (SeMaxinib);VEGFR2 Kinase Inhibitor III
- CBNumber:
- CB8504771
- Molecular Formula:
- C15H14N2O
- Molecular Weight:
- 238.28
- MDL Number:
- MFCD01940922
- MOL File:
- 204005-46-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
SU 5416 price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S8442 | SU 5416 ≥98% (HPLC) | 204005-46-9 | 5mg | $162 | 2024-03-01 | Buy |
| Cayman Chemical | 13342 | SU 5416 ≥98% | 204005-46-9 | 10mg | $122 | 2024-03-01 | Buy |
| Sigma-Aldrich | S8442 | SU 5416 ≥98% (HPLC) | 204005-46-9 | 25mg | $560 | 2024-03-01 | Buy |
| Cayman Chemical | 13342 | SU 5416 ≥98% | 204005-46-9 | 25mg | $289 | 2024-03-01 | Buy |
| Cayman Chemical | 13342 | SU 5416 ≥98% | 204005-46-9 | 50mg | $547 | 2024-03-01 | Buy |
SU 5416 Chemical Properties,Uses,Production
Uses
SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.
Uses
SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.3 It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.4
Uses
SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into t umor tissues.
Definition
ChEBI: Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis modulating agent. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole.
Biological Activity
Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.
Biochem/physiol Actions
SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2
storage
Desiccate at -20°C
SU 5416 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| Biochempartner | 58 |
| BOC Sciences | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Nextpeptide Inc | 58 |
| Labnetwork lnc. | 58 |
| InvivoChem | 58 |
