4-FLUORO-2-HYDROXYBENZOIC ACID
- CAS No.
- 345-29-9
- Chemical Name:
- 4-FLUORO-2-HYDROXYBENZOIC ACID
- Synonyms
- 4-FLUOROSALICYCLIC ACID;uorosaL;RARECHEM AL BE 1428;4-FLUOROSALICYLIC ACID;Tavaborole Impurity 23;luorohydroxybenzoicacid;4-FluorosalicylicAcid>Azithromycin Impurity 51;4-Fluorosalicylicacid,98%;fluorohydroxybenzoicacid5
- CBNumber:
- CB8663418
- Molecular Formula:
- C7H5FO3
- Molecular Weight:
- 156.11
- MDL Number:
- MFCD00153168
- MOL File:
- 345-29-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Fluorosalicylic acid 96% | 554332 | 1g | $34.96 |
| 4-Fluorosalicylic Acid >98.0%(GC)(T) | F0637 | 1g | $46 |
| 4-Fluorosalicylic Acid >98.0%(GC)(T) | F0637 | 5g | $136 |
| 4-Fluorosalicylic Acid >98.0%(GC)(T) | F0637 | 25g | $405 |
| 4-Fluoro-2-hydroxybenzoicacid | F596145 | 100mg | $45 |
| More product size | |||
| Melting point | 170 °C (dec.) (lit.) |
|---|---|
| Boiling point | 300.5±27.0 °C(Predicted) |
| Density | 1.492±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 2.85±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to orange |
| BRN | 2209124 |
| InChI | InChI=1S/C7H5FO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11) |
| InChIKey | TTZOLDXHOCCNMF-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(F)C=C1O |
| CAS DataBase Reference | 345-29-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
4-FLUORO-2-HYDROXYBENZOIC ACID price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 554332 | 4-Fluorosalicylic acid 96% | 345-29-9 | 1g | $34.96 | 2025-07-31 | Buy |
| TCI Chemical | F0637 | 4-Fluorosalicylic Acid >98.0%(GC)(T) | 345-29-9 | 1g | $46 | 2025-07-31 | Buy |
| TCI Chemical | F0637 | 4-Fluorosalicylic Acid >98.0%(GC)(T) | 345-29-9 | 5g | $136 | 2025-07-31 | Buy |
| TCI Chemical | F0637 | 4-Fluorosalicylic Acid >98.0%(GC)(T) | 345-29-9 | 25g | $405 | 2025-07-31 | Buy |
| TRC | F596145 | 4-Fluoro-2-hydroxybenzoicacid | 345-29-9 | 100mg | $45 | 2021-12-16 | Buy |
4-FLUORO-2-HYDROXYBENZOIC ACID Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
4-Fluorosalicylic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
General Description
4-Fluorosalicylic acid can be synthesized from the following compounds:
- 4-fluorotoluene
- m-fluorophenol
- 4-aminosalicylic acid
Synthesis
1583-58-0
345-29-9
General procedure for the synthesis of 4-fluorosalicylic acid from 2,4-difluorobenzoic acid: dimethylsulfoxide (DMSO, 4 L), 2,4-difluorobenzoic acid (500 g, 3.16 mol) and sodium hydroxide (NaOH, 253 g, 6.32 mol) were added to a dry 10 L four-neck flask. The mixture was heated to 130 °C and reacted for about 8 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction system was cooled to room temperature. Subsequently, the reaction solution was slowly poured into 40 L of ice water and the pH was adjusted to 2?3 with concentrated hydrochloric acid (care was taken that the temperature did not exceed 20 °C during the adjustment). At this time, a large amount of solid precipitated, continue to stir for 2 hours and then pump-filtered. The filter cake was washed with appropriate amount of water to obtain a white solid. The resulting solid was dried under reduced pressure at 60°C for 12 h. 450 g of 4-fluorosalicylic acid was finally obtained with a yield of 90% and a melting point of 184.9-185.2°C. The solid was dried at 60°C for 12 h under reduced pressure.
References
[1] Journal of Fluorine Chemistry, 2003, vol. 121, # 1, p. 97 - 99
[2] Patent: CN107501260, 2017, A. Location in patent: Paragraph 0030; 0031; 0033; 0034
[3] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 21, p. 5661 - 5675
[4] Patent: WO2013/148857, 2013, A1. Location in patent: Paragraph 00393; 00407; 00417
4-FLUORO-2-HYDROXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3999 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13505 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 4-FLUORO-2-HYDROXYBENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-06-04 | 4-FLUORO-2-HYDROXYBENZOIC ACID
345-29-9
|
US $1.00 / KG | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-03-28 | 4-FLUORO-2-HYDROXYBENZOIC ACID
345-29-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1000kg | LY Global chemicals co.,ltd . | |
 |
2019-07-14 | 4-FLUORO-2-HYDROXYBENZOIC ACID
345-29-9
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 4-FLUORO-2-HYDROXYBENZOIC ACID
345-29-9
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-FLUORO-2-HYDROXYBENZOIC ACID
345-29-9
- US $0.00-0.00 / kg
- 98%
- LY Global chemicals co.,ltd .
-
- 4-FLUORO-2-HYDROXYBENZOIC ACID
345-29-9
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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