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Chemical Name:
4-ACETOXY-2-AZETIDINONE;3-Acetoxy-3-propanelactam;4-Acetyloxyazetidin-2-one;4-OXOAZETIDIN-2-YLACETATE;2-oxoazetidinium 4-acetate;4-Oxo-2-azetidinyl acetate;2-Azetidinone, 4-(acetyloxy)-;4-ACETOXY-2-AZETIDINONE(4-AA);Acetic acid 4-oxo-2-azetidinyl ester;Acetic acid 2-oxoazetidin-4-yl ester
Molecular Formula:
Formula Weight:
MOL File:

4-Acetoxy-2-azetidinone Properties

Melting point:
38-40 °C(lit.)
Boiling point:
239.15°C (rough estimate)
1.3816 (rough estimate)
refractive index 
1.4220 (estimate)
Flash point:
>230 °F
storage temp. 
formic acid: soluble50mg/mL, clear, yellow-orange
CAS DataBase Reference
28562-53-0(CAS DataBase Reference)
NIST Chemistry Reference
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C
Risk Statements  34-43
Safety Statements  26-36/37/39-45
RIDADR  UN 1759 8/PG 2
WGK Germany  3
HazardClass  8
PackingGroup  III
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Acetoxy-2-azetidinone price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 272159 4-Acetoxy-2-azetidinone 98% 28562-53-0 1g $103 2018-11-20 Buy
Sigma-Aldrich 272159 4-Acetoxy-2-azetidinone 98% 28562-53-0 5g $322 2018-11-20 Buy

4-Acetoxy-2-azetidinone Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Purification Methods

Dissolve it in CHCl3, dry (MgSO4) concentrate at 40o/70mm, or better at room temperature to avoid decomposition. Wash and stir the residual oil with hexane by decantation and discard the wash. Dry the oil at high vacuum when it should solidify, m 34o. It can be distilled at high vacuum, 80-82o/10-3mm, but this results in extensive losses. The purity can be checked by TLC using Merck Silica Gel F254 and eluting with EtOAc. The azetidinone has RF 0.38 (typical impurities have RF 0.67). The spots can be detected by the TDM spray. This is prepared from (A) 2.5g 4,4'-tetramethyldiaminodiphenylmethane (TDM) in 10mL AcOH and diluted with 50mL of H2O, (B) 5g KI in 100mL of H2O and (C) 0.3g ninhydrin in 10mL of AcOH and 90mL of H2O. The spray is prepared by mixing (A) and (B) with 1.5mL of (C) and stored in a brown bottle. [Clau et al. Justus Liebigs Ann Chem 539 1974, Michel et al. Org Synth 65 135 1987, Beilstein 21/12 V 4.]

4-Acetoxy-2-azetidinone Preparation Products And Raw materials

Raw materials

Preparation Products

4-Acetoxy-2-azetidinone Suppliers

Global( 99)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Xishi Chemical (Shanghai) Co., Ltd. +86 (21) 6049-9358,13661956116
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Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
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Energy Chemical 021-58432009 / 400-005-6266
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Jia Xing Isenchem Co.,Ltd 0573-85280080,18627885956
0573-85285100,QQ:2446116053 China 9781 66
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 China 21889 59

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