Buflomedil
- CAS No.
- 55837-25-7
- Chemical Name:
- Buflomedil
- Synonyms
- BUFLOMEDIL;Buflomedilum;AURORA KA-850;BufluomedilHcl;Buflomedil Hcl 35543-24-9 / Base;Buflomedil (base and/or unspecified salts);2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon;4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
- CBNumber:
- CB8675435
- Molecular Formula:
- C17H25NO4
- Molecular Weight:
- 307.38
- MDL Number:
- MFCD00242740
- MOL File:
- 55837-25-7.mol
- MSDS File:
- SDS
| Boiling point | 454.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.090±0.06 g/cm3(Predicted) |
| pka | 10.15±0.20(Predicted) |
| LogP | 3.131 (est) |
| CAS DataBase Reference | 55837-25-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | V7I71DQ432 |
| ATC code | C04AX20 |
| NIST Chemistry Reference | Buflomedil(55837-25-7) |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn |
|---|---|
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | EL9885000 |
| HS Code | 29339990 |
Buflomedil Chemical Properties,Uses,Production
Originator
Fonzylane,Lafon,France,1976
Uses
BAN; DCF; MI.
Definition
ChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone.
Manufacturing Process
Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of
chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid
bubbler and condenser. Stir to dissolve and add 27.7 g of 4-
pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to
about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about
5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again
with 150 cm3 of water. Combine the aqueous layers, drive off the traces of
chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one
hour. Cool and render alkaline by means of 60 ml of sodium hydroxide
solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether
with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50
ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter,
wash with ether and dry in a vacuum oven. 33.6 g of crude product are
obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA
carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield:
39.2%. Instantaneous melting point: 192°-193°C.
Therapeutic Function
Vasodilator
Buflomedil Preparation Products And Raw materials
Buflomedil Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |