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CHLORPROPAMIDE

CHLORPROPAMIDE
CHLORPROPAMIDE
CAS No.
94-20-2
Chemical Name:
CHLORPROPAMIDE
Synonyms
p607;P-607;u-3818;u-9818;Adiaben;Asucrol;Catanil;Glisema;Meldian;Oradian
CBNumber:
CB8677954
Molecular Formula:
C10H13ClN2O3S
Formula Weight:
276.74
MOL File:
94-20-2.mol

CHLORPROPAMIDE Properties

Melting point:
128 °C
Boiling point:
302°C (rough estimate)
Density 
1.3046 (rough estimate)
refractive index 
1.6300 (estimate)
pka
pKa 4.8 (Uncertain)
Water Solubility 
Soluble in ethanol (1:12), acetone (1:5), chloroform (1:9) and solutions of alkali hydroxides. Does not mix well with water.
Merck 
14,2186
Stability:
Stable. Combustible.
CAS DataBase Reference
94-20-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  20/21/22-40
Safety Statements  22-36
WGK Germany  3
RTECS  YS6650000
Toxicity LD50 i.p. in rats: 580 mg/kg (Goldenthal)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

CHLORPROPAMIDE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1290 Chlorpropamide ≥97% 94-20-2 25g $73.1 2018-11-22 Buy
Sigma-Aldrich 1126009 Chlorpropamide 94-20-2 200mg $352.8 2018-11-20 Buy
TCI Chemical C1220 1-(4-Chlorophenylsulfonyl)-3-propylurea >99.0%(T) 94-20-2 25g $56 2018-11-22 Buy
Alfa Aesar J64110 Chlorpropamide 94-20-2 25g $58.4 2018-11-13 Buy
Alfa Aesar J64110 Chlorpropamide 94-20-2 100g $210 2018-11-13 Buy

CHLORPROPAMIDE Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

Chlorpropamide is a sulfonylurea derivative. Chlorpropamide is a long acting hyopglycemic agent. Chlorpropamide is used in the treatment of diabetes metilus type 2. Chlorpropamide acts to increase the secretion of insulin and is not effective in patients who do not have pancreatic beta cell function.

Uses

antidiabetic

Uses

For treatment of NIDDM in conjunction with diet and exercise.

Definition

ChEBI: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypogly aemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.

brand name

Diabinese (Pfizer); Glucamide (Teva).

General Description

White crystalline powder with a slight odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for CHLORPROPAMIDE are not available; however, CHLORPROPAMIDE is probably combustible.

Purification Methods

Crystallise the urea from aqueous EtOH. [Beilstein 11 IV 119.]

CHLORPROPAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products


CHLORPROPAMIDE Suppliers

Global( 112)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24654 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44192 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1960 70
Shanghai Longsheng chemical Co.,Ltd. 021-58099637,58099652,58099650,58099609 To 8009,8068; 13585536065,QQ:975986869
0086-21-33191781 sales@shlschem.com; bin.wu@shlschem.com;xianjun.hong@shlschem.com China 9839 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 20023 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32520 50
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771
sales@heowns.com China 14543 57

CHLORPROPAMIDE Spectrum


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