3-DEAZAADENOSINE
- CAS No.
- 6736-58-9
- Chemical Name:
- 3-DEAZAADENOSINE
- Synonyms
- C3-Ado;3-Deaza-rA;NSC 167897;3-DEAZAADENOSINE;3-Deaza-D-adenosine;3-Deazaadenosine ,98%;3-DEAZAADENOSINE USP/EP/BP;1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine;4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine;1H-Imidazo[4,5-c]pyridin-4-amine,1-b-D-ribofuranosyl-
- CBNumber:
- CB8680473
- Molecular Formula:
- C11H14N4O4
- Molecular Weight:
- 266.25
- MDL Number:
- MFCD00153951
- MOL File:
- 6736-58-9.mol
- MSDS File:
- SDS
| Melting point | 228-229°C |
|---|---|
| Boiling point | 665.7±65.0 °C(Predicted) |
| Density | 1.90±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: 10 mg/mL with heating to 60 °C |
| form | Solid |
| pka | 13.24±0.70(Predicted) |
| color | White to Off-White |
| FDA UNII | 037V4520IY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312-H315-H319-H331-H335 |
| Precautionary statements | P261-P280-P305+P351+P338-P311 |
| Safety Statements | 24/25 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29419090 |
3-DEAZAADENOSINE price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D8296 | 3-Deazaadenosine | 6736-58-9 | 5mg | $341 | 2024-03-01 | Buy |
| Sigma-Aldrich | D8296 | 3-Deazaadenosine | 6736-58-9 | 10mg | $614 | 2024-03-01 | Buy |
| Cayman Chemical | 9000785 | 3-Deazaadenosine ≥98% | 6736-58-9 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 9000785 | 3-Deazaadenosine ≥98% | 6736-58-9 | 5mg | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 9000785 | 3-Deazaadenosine ≥98% | 6736-58-9 | 10mg | $389 | 2024-03-01 | Buy |
3-DEAZAADENOSINE Chemical Properties,Uses,Production
Description
3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.
Chemical Properties
Bright Yellow Solid
Uses
Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
Biochem/physiol Actions
Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
in vitro
3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].
in vivo
in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].
References
[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).
3-DEAZAADENOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-DEAZAADENOSINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
View Lastest Price from 3-DEAZAADENOSINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-27 | 3-DEAZAADENOSINE
6736-58-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2020-01-10 | 3-DEAZAADENOSINE
6736-58-9
|
US $0.01 / KG | 1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
-
- 3-DEAZAADENOSINE
6736-58-9
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-DEAZAADENOSINE
6736-58-9
- US $0.01 / KG
- 98%; 99%
- Career Henan Chemical Co
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