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Trandolapril

CAS No.
87679-37-6
Chemical Name:
Trandolapril
Synonyms
Mavik;Odrik;Odric;Udrik;Gopten;Preran;ru44570;Trantowa;Ccris 6594;Olivetolic
CBNumber:
CB8682356
Molecular Formula:
C24H34N2O5
Molecular Weight:
430.54
MDL Number:
MFCD00865776
MOL File:
87679-37-6.mol
MSDS File:
SDS
Last updated:2023-08-04 21:29:34

Trandolapril Properties

Melting point 122-123°C
Boiling point 626.0±55.0 °C(Predicted)
Density 1.181±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form white powder
pka 3.15±0.20(Predicted)
color White to Off-White
CAS DataBase Reference 87679-37-6(CAS DataBase Reference)
FDA UNII 1T0N3G9CRC
ATC code C09AA10

Pharmacokinetic data

Protein binding >80 (as trandolaprilat)
Excreted unchanged in urine 10-15%
Volume of distribution 18 Litres
Biological half-life 16-24 / - (as trandolaprilat)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360D
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
WGK Germany  3
RTECS  NL6015178
HS Code  2933995300
NFPA 704
0
3 0

Trandolapril price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T4827 Trandolapril ≥98% (HPLC), white powder 87679-37-6 10mg $71.2 2024-03-01 Buy
Sigma-Aldrich PHR3146 Trandolapril pharmaceutical secondary standard, certified reference material 87679-37-6 250MG $200 2024-03-01 Buy
Sigma-Aldrich BP1089 Trandolapril British Pharmacopoeia (BP) Reference Standard 87679-37-6 200MG $257 2024-03-01 Buy
Sigma-Aldrich 1672687 Trandolapril United States Pharmacopeia (USP) Reference Standard 87679-37-6 125mg $436 2024-03-01 Buy
Cayman Chemical 13522 Trandolapril ≥98% 87679-37-6 25mg $121 2024-03-01 Buy
Product number Packaging Price Buy
T4827 10mg $71.2 Buy
PHR3146 250MG $200 Buy
BP1089 200MG $257 Buy
1672687 125mg $436 Buy
13522 25mg $121 Buy

Trandolapril Chemical Properties,Uses,Production

Description

Trandolapril is a new ACE inhibitor that is rapidly hydrolyzed, mainly in the liver, to its biologically active form, trandolaprilat. Compared with all other ACE inhibitors, trandolaprilat is reported to have the highest lipophilicity and the most prolonged ACE inhibitory activity. In hypertensive patients, trandolapril at a dose of 2 mg reduces blood pressure consistently throughout the 24 hour period after intake, making it one of the best once a day antihypertensive drugs. It has also been demonstrated to inhibit aortic atherosclerosis in the hyperlipidemic rabbit.

Chemical Properties

White or almost white powder.

Originator

Roussel Uclaf (France)

Uses

antibacterial

Uses

An antihypertensive. Angiotensin converting enzyme (ACE) inhibitor

Uses

Trandolapril has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on responsiveness of human retinal endothelial cells (HRECs) to vascular endothelial growth factor (VEGF).

Definition

ChEBI: Trandolapril is a heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is a dicarboxylic acid monoester, a dipeptide, an ethyl ester, a secondary amino compound, a tertiary carboxamide and an organic heterobicyclic compound. It is functionally related to a trandolaprilat.

brand name

Odrik; Udrik; Gopten

General Description

Trandolapril, 1-[2-(1-ethoxycarbonyl-3-phenylpropylamino)propionyl]octahydroindole-2-carboxylicacid (Mavik), is an indole-containing ACE inhibitorthat is structurally related to most of the precedingagents discussed. Enalapril is very similar to trandolapril,with the primary difference occurring in the heterocyclicsystems. The pyrrolidine of enalapril has been replacedwith an octahydroindole system. Much like enalaprilate,trandolapril must be hydrolyzed to tranolaprilate, which isthe bioactive species.

Biochem/physiol Actions

Trandolapril is an ACE inhibitor. Trandolapril differs from other ACE inhibitors in that it has a longer biological half-life and a high degree of lipophilicity.

Clinical Use

Angiotensin converting enzyme inhibitor:
Hypertension
Heat failure
After myocardial infarction

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Trandolapril is metabolised in the liver to the active trandolaprilat and to some inactive metabolites. About 33
% of an oral dose of trandolapril is excreted in the urine, mainly as trandolaprilat; the rest is excreted in the faeces.

Trandolapril Preparation Products And Raw materials

Global( 207)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Antai Fine Chemical Technology Co.,Limited
18503026267 info@antaichem.com CHINA 9641 58

View Lastest Price from Trandolapril manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trandolapril pictures 2024-03-28 Trandolapril
87679-37-6
US $560.00-555.00 / Grams 10Grams 99% 100Tons Hebei Dangtong Import and export Co LTD
Trandolapril pictures 2023-08-05 Trandolapril
87679-37-6
US $10.00 / KG 1KG 99% 5000000kg Hebei Mojin Biotechnology Co., Ltd
Trandolapril pictures 2023-06-26 Trandolapril
87679-37-6
US $200.00 / kg 1kg 99% 1000kg/Month Hebei Mingeng Biotechnology Co., Ltd
  • Trandolapril pictures
  • Trandolapril
    87679-37-6
  • US $560.00-555.00 / Grams
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • Trandolapril pictures
  • Trandolapril
    87679-37-6
  • US $10.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Trandolapril pictures
  • Trandolapril
    87679-37-6
  • US $200.00 / kg
  • 99%
  • Hebei Mingeng Biotechnology Co., Ltd

Trandolapril Spectrum

(2s-(1(r*(r*)),2-alpha,3a-alpha,7a-beta))-)amino)-1-oxopropyl) ru44570 (2s,3ar,7as)-1-[(2s)-2-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid Mavik, (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid (3αR.7αS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropy]-(S)-alanyl]oetahydroindole-2(S)-carboxylic acid TrandolaprilC24H34N205 Mavik, Odrik, Gopten, RU-44570 1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)- (9CI) 1H-Indole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2a,3aa,7ab]]- Gopten Odrik Trandolapril/(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic Acid TRANDOLAPRIL 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1- oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-alpha,7a-beta)) (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-3a,4,5,6,7,7a-hexahydro-2-indolinecarboxylic acid (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]alanyl]octahydro-1H-indole-2-carboxylic acid Odric Trantowa (2S,3Ar,7as)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester 1H-Indole-2-carboxylic acid, 1-((2S)-2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3ar,7as)- Ccris 6594 Trandolapril (125 mg) (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydro-1H-indole-2-carboxylic acid Preran Tarka(coMb. with verapaMil) Udrik (2S,3aR,7aS)- 1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)- (2S,3aR,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)octahydro-1H-indole-2-carboxylic acid 1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]octahydro-,(2S,3aR,7aS)- Trandolapril Ph. Eur. Olivetolic (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid Trandolapril Solution, 1000ppm Trandolapril Solution, 100ppm Trandolapril CRS Trandolapril USP/EP/BP Trandolapril (RU44570) Trandolapril D6 TrandolaprilQ: What is Trandolapril Q: What is the CAS Number of Trandolapril Q: What is the storage condition of Trandolapril Q: What are the applications of Trandolapril Trandolapril (1672687) Mavik RU-44570,collagen,UUD model,inhibit,arterial hypertrophy,congestive heart failure,cellular fibronectin accumulation,Angiotensin-converting Enzyme (ACE),hypertension,CHF,RU 44570,spontaneously hypertensive rats,RU44570,Trandolapril,Inhibitor,UUO model,orally active,nonsulfhydryl,myocardial infarction,unilateral ureteral obstruction,Trandolaprilat 87679-37-6 TERRAMYCIN API Intermediates & Fine Chemicals Pharmaceuticals