Flucloxacillin

Flucloxacillin Properties

Boiling point	677.3±55.0 °C(Predicted)
Density	1.59±0.1 g/cm3(Predicted)
solubility	soluble in Methanol, Water
pka	pKa 2.7 (Uncertain)
form	Solid
color	White
CAS DataBase Reference	5250-39-5(CAS DataBase Reference)
FDA UNII	43B2M34G2V
ATC code	J01CF05

Pharmacokinetic data

Protein binding	95%
Excreted unchanged in urine	66-76%
Volume of distribution	0.13
Biological half-life	53-60 minutes / 135-173 minutes

Flucloxacillin price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	257312	Flucloxacillin	5250-39-5	500mg	$1982	2021-12-16	Buy
AK Scientific	C572	Floxacillin	5250-39-5	2g	$4316	2021-12-16	Buy
AK Scientific	C572	Floxacillin	5250-39-5	500mg	$1670	2021-12-16	Buy
AvaChem	2014A	Flucloxacillin	5250-39-5	10mg	$39	2021-12-16	Buy
AvaChem	2014A	Flucloxacillin	5250-39-5	25mg	$49	2021-12-16	Buy

Product number	Packaging	Price	Buy
257312	500mg	$1982	Buy
C572	2g	$4316	Buy
C572	500mg	$1670	Buy
2014A	10mg	$39	Buy
2014A	25mg	$49	Buy

Flucloxacillin Chemical Properties,Uses,Production

Description

Chemically this is 3(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl penicillin; this differs from dicloxacillin only by the substitution of a fluorine for a chlorine atom (Sutherland et al., 1970). It comes as oral capsules of 250 and 500 mg, as a suspension of 25 and 50 mg/ml, and in an injectable formulation of 500 mg and 1 g.

Originator

Floxapen,Beecham,UK,1970

Uses

Antibacterial.

Definition

ChEBI: A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain.

Manufacturing Process

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylicacid, MP 206° to 207°C, was obtained by chlorinating 2-chloro-6-fluorobenzaldoxime, then condensing the resulting hydroxamoyl chloride with methyl acetoacetate in methanolic sodium methoxide and hydrolyzing the resulting ester with hot alkali. The acid chloride resulted from treatment of the acid with thionyl chloride
A suspension of 6-aminopenicillanic acid (36.4 grams) in water was adjusted to pH 7.2 by the addition of N aqueous sodium hydroxide and the resulting solution was treated with a solution of 3-(2-chloro-6-fluorophenyl)-5- methylisoxazole-4-carbonyl chloride (46.1 grams) in isobutyl methyl ketone. The mixture was stirred vigorously for 1? hours and then filtered through Dicalite. The layers were separated and the isobutyl methyl ketone layer was shaken with saturated brine. Then, precipitation of the sodium salt only took place after dilution of the mixture with ether. In this way there was obtained 60.7 grams of the penicillin sodium salt having a purity of 88% as determined by alkalimetric assay.

Therapeutic Function

Antibacterial

Antimicrobial activity

There is complete cross-resistance with other penicillinase-stable penicillins.

General Description

Flucloxacillin was synthesized by Beecham Research Laboratories in 1962 as a penicillinase-stable and orally active semisynthetic penicillin. It shows almost the same activity as dicloxacillin, and it has slightly higher serum and tissue concentrations than dicloxacillin. This drug has been used to treat pyoderma, sepsis, and postoperative infections as well as ear and nose, respiratory tract, and other infections caused by Staphylococcus and Streptococcus, including benzylpenicillin-resistant strains.

Pharmacokinetics

Oral absorption: c. 80%
C_max 250 mg (oral): 11 mg/L after 0.5–1 h
Plasma half-life: 2 h
Plasma protein binding: 95%
Absorption and distribution
It is well absorbed after oral administration and penetrates rapidly into extravascular exudates. Its high protein binding limits its diffusion, notably into the normal CSF.
Metabolism and excretion
Flucloxacillin is partly metabolized in the liver and about 10% of the plasma concentration is made up of metabolites. It is more slowly eliminated than cloxacillin. Some appears in the bile but about 50–80% of an oral dose is recovered from the urine, about 20% as metabolites.

Clinical Use

Uses are those of group 3 penicillins.

Side effects

In patients treated by intravenous infusion, about 5% developed phlebitis by the first and 15% by the second day, after which the proportion rose dramatically. Side effects are otherwise those common to penicillins.

Drug interactions

Potentially hazardous interactions with other drugs
Reduces excretion of methotrexate.

Metabolism

In normal subjects approximately 10% of the flucloxacillin administered is metabolised to penicilloic acid. Excretion occurs mainly through the kidney. Between 65.5% (oral route) and 76.1% (parenteral route) of the dose administered is recovered in unaltered active form in the urine within 8 hours. A small portion of the dose administered is excreted in the bile.

Flucloxacillin Preparation Products And Raw materials

Raw materials

Thionyl chloride Sodium hydroxide Sodium Methoxide Methyl acetoacetate Chlorine

6-Aminopenicillanic acid 2-CHLORO-6-FLUOROBENZALDOXIME

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Preparation Products

Flucloxacillin Suppliers

Global( 83)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3537	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Flucloxacillin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-06-25	Flucloxacillin USP/EP/BP 5250-39-5	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2020-05-10	Flucloxacillin 5250-39-5	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
2019-12-26	Flucloxacillin 5250-39-5	US $1.00 / g	1g	≥98%	g/kg/Ton	Career Henan Chemical Co

Flucloxacillin USP/EP/BP
5250-39-5
US $1.10 / g
99.9%
Dideu Industries Group Limited

Flucloxacillin
5250-39-5
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Flucloxacillin
5250-39-5
US $1.00 / g
≥98%
Career Henan Chemical Co

5250-39-5(Flucloxacillin)Related Search:

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Flucloxacillin sodium BP98,Sodium flucloxacillin,FLUCLOXACILLIN SODIUM Difluorochloromethane Methyl bromide

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(2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-1,2-oxazol-4-yl]carbonylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-7-keto-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Fluchlxacillin Flopen Floxapen Flucil Flucloxcillin Staphylex FLOXACILLIN FLUCLOXACILLIN [3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo- (8CI) 6-[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 6-[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]penicillanic acid Abboflox BRL 2039 Culpen FK 900 Fluoxacillin Flupen Penplus Staphlipen (2S,5R,6R)-6-[[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Flucloxacillin USP/EP/BP (2S,5R,6R)-6-(3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (Cloxacillin Impurity) Phenylbutazone Impurity 34 5250-39-5 C19H16CLFN3NaO5SH2O API's