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Propiophenone

Description References
Propiophenone
Propiophenone structure
CAS No.
93-55-0
Chemical Name:
Propiophenone
Synonyms
FEMA 3469;Propiophene;usafek-1235;Propiophenon;USAF ek-1235;PROPIOPHENONE;phenylpropone;Proopiophenone;Propionphenone;phenylpropanone
CBNumber:
CB8695754
Molecular Formula:
C9H10O
Formula Weight:
134.18
MOL File:
93-55-0.mol

Propiophenone Properties

Melting point:
17-19 °C(lit.)
Boiling point:
218 °C(lit.)
Density 
1.009 g/mL at 25 °C(lit.)
vapor pressure 
1 mm Hg ( 50 °C)
FEMA 
3469 | PROPIOPHENONE
refractive index 
n20/D 1.526(lit.)
Flash point:
190 °F
storage temp. 
Store below +30°C.
solubility 
Difficult to mix.
form 
Liquid
color 
Clear colorless to light yellow
Water Solubility 
INSOLUBLE
JECFA Number
824
Merck 
14,7830
BRN 
606215
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
KRIOVPPHQSLHCZ-UHFFFAOYSA-N
CAS DataBase Reference
93-55-0(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
PROPIOPHENONE
EWG's Food Scores
1
FDA UNII
E599A8OKQH
NIST Chemistry Reference
1-Propanone, 1-phenyl-(93-55-0)
EPA Substance Registry System
Propiophenone (93-55-0)
SAFETY
  • Risk and Safety Statements
Hazard statements  H227
Precautionary statements  P210e-P280a-P370+P378a-P403+P235-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  UG7175000
TSCA  Yes
HS Code  2914 39 00
Toxicity LD50 orally in Rabbit: 4490 mg/kg LD50 dermal Rabbit 4490 mg/kg
NFPA 704
1
0 0

Propiophenone price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W346918 Propiophenone ≥99% 93-55-0 sample $50 2020-08-18 Buy
Sigma-Aldrich W346918 Propiophenone ≥99% 93-55-0 1kg $120 2020-08-18 Buy
Alfa Aesar A15140 Propiophenone 99% 93-55-0 2500g $175 2020-06-24 Buy
Alfa Aesar A15140 Propiophenone 99% 93-55-0 100g $19.8 2020-06-24 Buy
Sigma-Aldrich P51605 Propiophenone 99% 93-55-0 100g $21.8 2020-08-18 Buy

Propiophenone Chemical Properties,Uses,Production

Description

Propiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.

References

https://en.wikipedia.org/wiki/Propiophenone
https://pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top
http://www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm
https://www.alfa.com/en/catalog/A15140/

Chemical Properties

Propiophenone has a strong, flowery odor.

Chemical Properties

colourless to light yellow liquid

Occurrence

Reported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.

Uses

Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.

Uses

In perfumery; in the synthesis of ephedrine and related Compounds.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.

Production Methods

Propiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Propiophenone Preparation Products And Raw materials

Raw materials

Preparation Products


Propiophenone Spectrum


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