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Borneol

Description References
Borneol
Borneol structure
CAS No.
507-70-0
Chemical Name:
Borneol
Synonyms
Camphol;Bingpian;2-Borneol;FEMA 2157;n-Borneol;(-)-BORNEOL;5CAPB 5cabp;baroscamphor;endo-Borneol;BORNEOL, (-)-
CBNumber:
CB8697516
Molecular Formula:
C10H18O
Formula Weight:
154.25
MOL File:
507-70-0.mol

Borneol Properties

Melting point:
206-209 °C
Boiling point:
210 °C(lit.)
alpha 
-0.5~+0.5゜(20℃/D)(c=5,C2H5OH)
Density 
1.011
vapor density 
5.31 (vs air)
vapor pressure 
33.5 mm Hg ( 25 °C)
FEMA 
2157 | BORNEOL
refractive index 
1.4831 (estimate)
Flash point:
150 °F
pka
15.36±0.60(Predicted)
Water Solubility 
insoluble
JECFA Number
1385
Merck 
14,1338
Stability:
Stable. Highly flammable. Incompatible with strong oxidizing agents.
InChIKey
DTGKSKDOIYIVQL-WEDXCCLWSA-N
Substances Added to Food (formerly EAFUS)
BORNEOL
CAS DataBase Reference
507-70-0(CAS DataBase Reference)
FDA UNII
M89NIB437X
NIST Chemistry Reference
Borneol(507-70-0)
EPA Substance Registry System
Borneol (507-70-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07
Signal word  Warning
Hazard statements  H228-H302
Precautionary statements  P210-P240-P241-P264-P270-P280-P301+P312+P330-P501
Hazard Codes  F,Xi,Xn
Risk Statements  11-43-22
Safety Statements  16-36/37
RIDADR  UN 1312 4.1/PG 3
WGK Germany  2
RTECS  DT5095000
HazardClass  4.1
PackingGroup  III
HS Code  29061990
NFPA 704
2
2 0

Borneol price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14472 (1S)-(-)-Borneol for synthesis 507-70-0 25 g $76.96 2021-03-22 Buy
Sigma-Aldrich 8.14472 (1S)-(-)-Borneol for synthesis 507-70-0 100 g $111.92 2021-03-22 Buy
Sigma-Aldrich 8.14472 (1S)-(-)-Borneol for synthesis 507-70-0 250 g $114.7 2021-03-22 Buy
TCI Chemical B0525 Borneol (contains ca. 20% Isoborneol) >70.0%(GC) 507-70-0 25g $33 2021-03-22 Buy
TCI Chemical B0525 Borneol (contains ca. 20% Isoborneol) >70.0%(GC) 507-70-0 500g $142 2021-03-22 Buy

Borneol Chemical Properties,Uses,Production

Description

Borneol, also called “compound long nao,” is a colorless and transparent crystal, which has a pungent, camphor-like odor and a burning taste reminiscent of mint. It occurs naturally in cinnamon leaf, ginger, Thymus, cardamom, coriander leaf, coriander seed, etc. Borneol has been shown to enhance blood-brain barrier (BBB) permeability and increase brain concentrations of drugs, as well as protect the brain and BBB while inducing no pathological damage. Thus, borneol is used as a promoter of drug absorption. Borneol is also used as a food additive permitted for direct addition to food for human consumption.

References

[1] N. Zhang, P. Liu and X. He, Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum, Neural Regen Res., 2012, vol. 7, 440-444
[2] George A. Burdock, Encyclopedia of Food and Color Additives, Volume 1, 2000

Description

l-Borneolum was originally from the Compositae Aenean Blumea balsamifera (L.) DC (Ai Na Xiang). Its crystals were made after being extracted from the fresh leaves of Ai Na Xiang. It is an optical isomer with natural borneol. It’s usually used for making spice the same as natural borneol, synthesized borneol, and so on .
Ai Na Xiang is a traditional Chinese medicine alias as Da Feng Ai, Niu Er Ai, etc. It has been recorded firstly in Guang Zhi, “Ai Na Xiang came from the west country and looks like the artemisia.” It has been recorded in many Chinese materia medica books, such as Hai Yao Ben Cao, Ling Nan Cai Yaolu, etc. In Zhong hua Ben cao (Chinese Materia Medica), the literature described it as “Ai Na Xiang (l-borneolum) has the fragrance because it is like the artemisia. It can also be prepared to the borneol, so it is called “Bing Pian Ai.” It is believed that this is the earliest records that Ai Na Xiang was made into borneol . In China, the authentic product area of l-borneolum is in Luodian, Guizhou Province . There are no other plant resources reported for producing l-borneolum in China.

Chemical Properties

solid

Chemical Properties

Borneol is a bicyclic terpene alcohol. Borneol is an endo isomer; the corresponding exo isomer is isoborneol:
Borneol occurs abundantly in nature as a single enantiomer or, less frequently, as the racemate. (1S,2R,4S)-(?)-Borneol occurs particularly in oils from Pinaceae species and in citronella oil. (1R,2S,4R)-(+)-Borneol is found, for example, in camphor oil (Ho-Sho oil), rosemary, lavender, and olibanum oils. Borneol is a colorless, crystalline solid. (+)-Borneol has a camphoraceous odor, with a slightly sharp, earthy, peppery note, which is less evident in (?)-borneol. Commercial borneol is often levorotatory ([α]20 D ?18 to ?28 in ethanol) and contains (?)-borneol and up to 40% isoborneol.
Borneol is oxidized to camphor with chromic or nitric acid; dehydration with dilute acids yields camphene. Borneol is readily esterified with acids, but on an industrial scale, bornyl esters are prepared by other routes. For example, levorotatory borneol is synthesized industrially from levorotatory pinenes by Wagner–Meerwein rearrangement with dilute acid, followed by hydrolysis of the resulting esters.
Borneol is used in the reconstitution of the essential oils in which it occurs naturally.

Chemical Properties

Borneol has a piney, camphor-like odor and burning taste somewhat reminiscent of mint.

Physical properties

Appearance: white translucent flakes, bulk or granular crystals. With a clear aroma, spicy, cool, volatile, black smoke, and yellow flame when lit without residue left. Melting point: 201–205? °C.? Soluble in ethanol, chloroform, or ether, almost insoluble in water. Specific optical rotation: ?36.5° to ?38.5° in 5% (g/mL) ethanol solution, stable under sealed condition at room temperature.
Pungent, bitter, slightly cold; heart, spleen, and lung meridians entered. (In Chinese traditional medicine’s opinion)

Occurrence

Unlike isoborneol, free or esterified borneol has been identified in more than 250 distillates from plants, herbs, leaves or bark; Compositae, Ericaceae, Lauraceae, Labiatea, Rutaceae; natural borneol can be d or l rotatory, but very seldom also racemic; most frequently encountered is the l-borneol characteristic of Compositae, Graminaceae and almost all Pinaceae; d-borneol characteristic of Cupressaceae, Zingiberaceae, lavender, lavandin and spike oils. Reported found in citrus peel oils (orange, lemon, lime), cinnamon leaf, cassia leaf, ginger, coriander seed, laurel, Ocimum basilicum, Thymus vulgaris L. and Curcuma aeruginosa Roxb.

History

l-Borneolum is one of the few drugs used from ancient times which is a single organic small molecule. With the progress of technology in modern times, it was found that there are optical differences by measuring the polarimetry, and accordingly the borneol is divided into three drugs: natural borneol (d-borneol), ai pian (l-borneol), and artificial borneol (synthetic borneol or dl-borneol).
The researches of l-borneolum are inextricably linked to borneol, but compared with the borneol, l-borneolum still has significant disadvantages. For example, borneol is used in the wider region than 1-borneolum which is mainly used in China. The pharmacological studies of borneol in modern times are much more than l-borneolum as well. The plant resources of borneol are the Cinnamomum camphora, known as the “woody incense,” and the plant resources of l-borneolum are Ai Na Xiang, known as “herbal fragrance.” From the Chinese traditional habits, it is thought that woody incense is better than herbal fragrance, so l-borneolum’s usage is limited. The purification process of borneol was done earlier than l-borneolum, and the process is excellent, with less camphor, isosorbide, and other toxic components. l-Borneolum has less purification process due to the small distribution range. Until the 1970s, l-borneolum was produced using the traditional manual process, leading to the low rate of borneol and high toxic components, finally affecting its clinical usage. In the 1980s and 1990s of the twentieth century, with the reduction of plant resources of natural borneol, the increasing demands of borneol and the poor synthesis process of borneol, the plant cultivation and purification studies of l-borneolum were developed for a while. However, with the continuous discovery of plant resources of natural borneol and the improvement of synthesis process, the research of l-borneolum was back to normal.

Uses

Perfumery, esters.

Indications

Sore throat, aphthous, red eyes, purulent ear discharge, convulsions, febrile delirium, sudden faint due to qi depression, stroke, and coma

Definition

ChEBI: A bornane monoterpenoid that is 1,7,7-trimethylbicyclo[2.2.1]heptane substituted by a hydroxy group at position 2.

Aroma threshold values

Detection: 140 ppb

General Description

A white colored lump-solid with a sharp camphor-like odor. Burns readily. Slightly denser than water and insoluble in water. Used to make perfumes.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

Borneol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Hazard

Fire risk in presence of open flame.

Health Hazard

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Pharmacology

The main effects of l-borneolum are to induce resuscitation (with aromatic stimulation), clear stagnated fire (fever feeling), remove nebula to improve eyesight, and relieve swelling and pain. In traditional Chinese medicine, borneol is often used as an envoy drug and combined with other drugs.
The modern pharmacological researches showed that l-borneolum can cross the blood-brain barrier (BBB) through increasing cell membrane fluidity, Na+ -K+- ATPase activity, decreasing membrane potential, and regulating intracellular calcium concentration, which is involved in the effect of resuscitation .
The key brain-protective mechanism of l-borneolum and synthetic borneol is closely related to the regulation of P-glycoprotein pathway, lipid peroxidation, and nitric oxide pathway. In addition, it can regulate the calcium pathway, which is the main biological mechanism of “Xin-floating-heart” medicinal property of borneol and resuscitation. Based on the statistical results of strength integral law, it demonstrated that the brain-protective effect of l-borneolum is stronger than synthetic borneol, suggesting that we should prefer l-borneolum for the treatment of cerebrovascular disease .

Clinical Use

l-Borneolum is used as a kind of borneol in clinical usage all along, but its clinical usage is fewer than borneol considering its clinical efficacy is weaker than borneol. The main reasons may be the following aspects: the discovery of l-borneolum is later than borneol, and the processing technology of l-borneolum is far behind borneol which leads to high impurities. l-Borneolum has less adverse reactions the same as borneol, including gastrointestinal irritation, reproductive toxicity, and allergic reactions.

Chemical Synthesis

Racemic borneol is prepared synthetically by reduction of camphor or from pinene.

Borneol Preparation Products And Raw materials

Raw materials

Preparation Products


Borneol Suppliers

Global( 326)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58

View Lastest Price from Borneol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 Borneol
507-70-0
US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-09-29 Natural Borneol
507-70-0
US $0.00-0.00 / Kg/Drum 1KG 96%min 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-24 Borneol
507-70-0
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

Borneol Spectrum


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