Pyrazole-3-boronic acid
- CAS No.
- 376584-63-3
- Chemical Name:
- Pyrazole-3-boronic acid
- Synonyms
- 1H-PYRAZOLE-3-BORONIC ACID;1H-Pyrazole-5-boronic acid;e-5-boronic acid;CHEMBRDG-BB 4201615;3-Pyrazoleboronicacid;Pyrazole-3-boronicaci;Pyrazole-2-boronic acid;Pyrazole-3-boronic acid;Pyrazole-5-boronic acid;Pyrazol-3-ylboronic acid
- CBNumber:
- CB8704890
- Molecular Formula:
- C3H5BN2O2
- Molecular Weight:
- 111.89
- MDL Number:
- MFCD02020768
- MOL File:
- 376584-63-3.mol
- MSDS File:
- SDS
| Melting point | 85-88°C |
|---|---|
| Boiling point | 430.4±37.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | solid |
| pka | 8.58±0.53(Predicted) |
| color | Off-white |
| Water Solubility | Soluble in water. |
| InChI | InChI=1S/C3H5BN2O2/c7-4(8)3-1-2-5-6-3/h1-2,7-8H,(H,5,6) |
| InChIKey | NEUWPDLMDVINSN-UHFFFAOYSA-N |
| SMILES | N1C=CC(B(O)O)=N1 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933199090 | |||||||||
| NFPA 704 |
|
Pyrazole-3-boronic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H27286 | 1H-Pyrazole-3-boronic acid hydrate, 95% | 376584-63-3 | 1g | $186.65 | 2024-03-01 | Buy |
| Usbiological | 287935 | 1H-Pyrazol-3-yl boronic acid | 376584-63-3 | 500mg | $360 | 2021-12-16 | Buy |
| TRC | B529883 | 1h-Pyrazole-3-boronicAcid | 376584-63-3 | 100mg | $45 | 2021-12-16 | Buy |
| AK Scientific | J92698 | (1H-Pyrazol-3-yl)boronicacid | 376584-63-3 | 1g | $49 | 2021-12-16 | Buy |
| Apolloscientific | OR8413 | 1H-Pyrazole-5-boronicacid | 376584-63-3 | 1g | $56 | 2021-12-16 | Buy |
Pyrazole-3-boronic acid Chemical Properties,Uses,Production
Uses
Significantly used as synthetic intermediates. They are widely used in the production of optics.
Synthesis
449758-17-2
376584-63-3
General procedure for the synthesis of 1H-pyrazole-3-boronic acid from 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole: To a solution of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole (7.6 g, 52 mmol) in tetrahydrofuran (THF, 50 mL) was added slowly at -78 °C n-butyllithium (n-BuLi, 33 mL, 2.5 M hexane solution, 82.5 mmol), followed by the addition of triisopropylborane (12.7 mL, 55 mmol) dropwise, keeping the reaction temperature at -70 °C. The reaction mixture was stirred at -70 °C for 1 hour and then slowly warmed to room temperature over 4 hours. After completion of the reaction, the reaction was quenched with 2M hydrochloric acid (HCl) and the solvent was removed under vacuum. The pH of the reaction mixture was adjusted to 6 with 1M sodium hydroxide (NaOH) solution, at which time a precipitate was formed. The precipitate was collected by filtration, washed sequentially with toluene and petroleum ether, and finally ground with ethyl acetate to afford 1H-pyrazole-3-boronic acid as a white solid (2.7 g, 48% yield), and the product could be used in subsequent reactions without further purification.
References
[1] Patent: WO2007/138072, 2007, A2. Location in patent: Page/Page column 55
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 2995 - 3008
Pyrazole-3-boronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 6842 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from Pyrazole-3-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-05 | 1H-Pyrazol-3-ylboronic acid
376584-63-3
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-04-04 | Pyrazole-3-boronic acid
376584-63-3
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | Pyrazole-3-boronic acid
376584-63-3
|
US $1.00 / kg | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- 1H-Pyrazol-3-ylboronic acid
376584-63-3
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Pyrazole-3-boronic acid
376584-63-3
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Pyrazole-3-boronic acid
376584-63-3
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co