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Deflazacort

Description Chemical Properties Application Adverse effects Precautions Drug interactions Preparation References
Deflazacort
Deflazacort structure
CAS No.
14484-47-0
Chemical Name:
Deflazacort
Synonyms
oxaz;deflan;Cortax;l-5458;calcort;azacort;MDL 458;Dezacor;Azaeort;Caltort
CBNumber:
CB8705963
Molecular Formula:
C25H31NO6
Formula Weight:
441.52
MOL File:
14484-47-0.mol

Deflazacort Properties

Melting point:
255-256.5°C
alpha 
D +62.3° (c = 0.5 in chloroform)
Boiling point:
595.4±50.0 °C(Predicted)
Density 
1.41
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
pka
14.30±0.70(Predicted)
form 
powder
color 
white to tan
Merck 
14,2862
FDA UNII
KR5YZ6AE4B
NCI Drug Dictionary
deflazacort
ATC code
H02AB13
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
RTECS  TU4157050
HS Code  29349990
Toxicity LD50 orally in mice: 5200 mg/kg (Schiatti)

Deflazacort price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0123 Deflazacort ≥98% (HPLC) 14484-47-0 10mg $115 2021-03-22 Buy
Sigma-Aldrich 1166116 Deflazacort United States Pharmacopeia (USP) Reference Standard 14484-47-0 100mg $366 2021-03-22 Buy
TCI Chemical D4523 Deflazacort >98.0%(HPLC)(N) 14484-47-0 1g $175 2021-03-22 Buy
TCI Chemical D4523 Deflazacort >98.0%(HPLC)(N) 14484-47-0 5g $606 2021-03-22 Buy
Cayman Chemical 20386 Deflazacort ≥98% 14484-47-0 25mg $25 2021-03-22 Buy

Deflazacort Chemical Properties,Uses,Production

Description

Deflazacort (trade name Emflaza among others) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid.
Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort.It is used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, systemic lupus erythematosus (SLE), autoimmune hepatitis, sarcoidosis), joint and muscle diseases (for example, rheumatoid arthritis), and allergies and asthma.
Cardiff can be specially designed for the third generation of corticosteroids, anti-inflammatory, anti-allergy, and it increased gluconeogenesis and so on. It acts as prednisolone 10~20 times of the dragon, 40 times as hydrocortisone. This product has no mutagenic effect. This product, labeled with C14 study, shows that the product of the gastrointestinal tract rapidly absorbed, reaching the peak blood concentration after 1~2h, forming the active substance by hydrolysis, and the latter further metabolic processes is similar with other corticosteroids, as well as the active metabolite T1/2 is 2 h and the rats are mainly distributed in the kidney and hematopoietic system and other organizations.
deflazacort formula
Figure 1 is a deflazacort formula.

Chemical Properties

Acetone-hexane, m.p. 255-256.5 ℃. [Α] D + 62.3 ° (C = 0.5, chloroform). UV absorption maximum (methanol): 241~242nm (E1cm1% 352.5). Acute toxicity LD50 in mice (mg/kg): 5200 oral; 1610 subcutaneous injection. Rats Acute toxicity LD50 (mg/kg): 109 subcutaneously. Dog Acute toxicity LD50 (mg/kg):> 4000 Oral; 50 subcutaneous injection.

Application

 The third generation of corticosteroids, anti-inflammatory, anti-allergy, increased gluconeogenesis and so on. For the use of the primary and secondary adrenocortical insufficiency, rheumatism, collagen diseases, skin diseases, allergic diseases, eye diseases, and fulminant disseminated tuberculosis, hematopoietic system disorders, ulcerative colitis, idiopathic nephrotic syndrome, and other hematopoietic malignancies.

Adverse effects

Deflazacort carries the risks common to all corticosteroids, including immune suppression, decreased bone density, and endocrine insufficiency. In clinical trials, the most common side effects (>10% above placebo) were Cushing's-like appearance, weight gain, and
increased appetite.
Long-term medication can affect the normal growth of children, induced peptic ulcer perforation, which can cause euphoria, depression, insomnia and other psychiatric symptoms. Sudden withdrawal after long-term use can cause secondary adrenal insufficiency withdrawal reactions, which should gradually decrease until disabled.

Precautions

Drug interactions

Preparation

Compound 10g (1) was dissolved in 350ml methanol, and then added 8.3g of semicarbazide hydrochloride and 5.75ml of pyridine in 50ml of water, after the reaction. We can obtain compound 11g (Ⅱ). Compound 9g (Ⅱ) was dissolved 230ml 95% ethanol, the solution was added 3.6g of potassium carbonate and 2.34g of sodium borohydride in 36ml of water, which was refluxed for 30min and then added 2.34g of sodium borohydride. After the reaction, we can obtain compound 8.5g (Ⅲ). Compound 7.7g (Ⅲ) was dissolved in 154ml 10% hydrochloric acid in methanol, refluxed for 1h, to give Compound 6g (Ⅳ). Compound 12.5g (Ⅳ) was dissolved in 500ml of anhydrous toluene and 90ml of cyclohexanone. It was added 6.24g triisopropyl aluminum, 9g obtained by reacting the compound (V). 6.5g compound (V) was dissolved in 123ml dry dioxane, and 25% hydrogen bromide in acetic acid solution is heated, and then added 5.5g of bromine in dioxane; the reaction solution was poured into the water, collected by filtration after the crystals were carefully dried, redissolved in dimethylformamide. It  was added 7.5g of lithium bromide and lithium carbonate (1: 2) mixture. After heating the reaction, we can obtain the compound 5.1g (ⅵ). 2g compound (Ⅵ) was dissolved in tetrahydrofuran-methanol (1: 1), added to 3.9g calcium oxide and 0.1g of azobisisobutyronitrile. It was added 2g of iodine in tetrahydrofuran-methanol mixture; After the reaction was filtered off precipitate , which was dissolved in acetone,  it was then added triethylamine 20ml, 20ml and 12ml acetone, acetic acid, atter the reaction, we can obtain 1.6g deflazacort.

References

https://en.wikipedia.org/wiki/Deflazacort
http://patient.info/medicine/deflazacort-tablets-calcort

Description

Deflazacort is an antiinflammatory treatment of rheumatoid arthritis. Its antirheumatic potency i s similar to that of prednisone, while its hyperglycernic and calcium depleting effects are reportedly less.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Dow Lepetit (Italy)

Uses

A systemic corticosteroid. A derivative of prednisolone. Used for rheumatoid arthritis and lupus

Uses

antiinflammatory

brand name

LANTADIN; DEFLAN

Deflazacort Preparation Products And Raw materials

Raw materials

Preparation Products


Deflazacort Suppliers

Global( 282)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5892 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

View Lastest Price from Deflazacort manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 10-Deacetylbaccatin III
32981-86-5
US $10.00 / KG 1KG 99 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-12-01 Deflazacort
14484-47-0
US $10.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-12-01 Deflazacort
14484-47-0
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

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