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(-)PPP

(-)PPP Structure
(-)PPP structure
CAS No.
477-47-4
Chemical Name:
(-)PPP
Synonyms
(-)PPP;(-)PPP;AXL1717;AXL 1717;AXL-1717;NSC 36407;Metacavir;PICROPODOPHYLLIN;(-)PPP USP/EP/BP;Pictopodophyllotoxin
CBNumber:
CB8708520
Molecular Formula:
C22H22O8
Molecular Weight:
414.41
MDL Number:
MFCD01742647
MOL File:
477-47-4.mol
MSDS File:
SDS
Last updated:2024-04-23 17:50:46
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(-)PPP Properties

Melting point 225-227℃
alpha D20 +9.4° (c = 0.7 in chloroform)
Boiling point 453.31°C (rough estimate)
Density 1.370
refractive index 1.4480 (estimate)
storage temp. Sealed in dry,2-8°C
solubility H2O: soluble
form powder
pka 13.26±0.40(Predicted)
color white
Sensitive Light Sensitive
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
FDA UNII 0F35AOI227
NCI Drug Dictionary picropodophyllin

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H312-H315-H319-H335
Precautionary statements  P261-P264-P280-P301+P310-P302+P352+P312-P305+P351+P338
Hazard Codes  Xi,T
Risk Statements  36/37/38-68-25-21
Safety Statements  26-36-45-36/37
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  LV2510000
HazardClass  6.1
Toxicity LD50 intraperitoneal in mouse: 280mg/kg

(-)PPP price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T9576 Picropodophyllotoxin ≥96% (HPLC), powder 477-47-4 1mg $150 2024-03-01 Buy
Sigma-Aldrich 407247 IGF-1R Inhibitor, PPP 477-47-4 1mg $172 2024-03-01 Buy
Sigma-Aldrich 659223 Poly(2,5-bis(3-sulfonatopropoxy)-1,4-phenylene, disodium salt-alt-1,4-phenylene) light emitting, fluorescence λem?424?nm in H2O 477-47-4 500MG $431 2023-06-20 Buy
Alfa Aesar J65916 IGF-1R Inhibitor, PPP 477-47-4 10mg $220 2023-06-20 Buy
Cayman Chemical 17329 Picropodophyllotoxin ≥98% 477-47-4 1mg $44 2024-03-01 Buy
Product number Packaging Price Buy
T9576 1mg $150 Buy
407247 1mg $172 Buy
659223 500MG $431 Buy
J65916 10mg $220 Buy
17329 1mg $44 Buy

(-)PPP Chemical Properties,Uses,Production

Description

Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1?Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM.1?Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM.2 Exhibits antiangiogenic activity.3?Picropodophyllotoxin attenuates intimal hyperplasia after vascular injury.4?Active in vivo.

Uses

Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor

Uses

Insulin growth factor 1 receptor inhibitor, antineoplastic

Definition

ChEBI: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.

General Description

Poly(2,5-bis(3-sulfonatopropoxy)-1,4-phenylene, disodium salt-alt-1,4-phenylene) (PPP-OPSO3) is a water soluble conjugating polymer that can be used as a donor molecule. It has a poly(p-phenylene) skeleton with each repeating unit having two phenylene groups. It can be used for a variety of optoelectronic applications.

Biological Activity

Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .

Biochem/physiol Actions

Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable.

storage

Store at +4°C

References

1) Girnita et al. (2004), Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth; Cancer Res., 64 236 2) Girnita et al. (2006), The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of iveal melanoma cells; Clin. Cancer Res., 12 1383 3) Menu et al. (2007), Targeting the IGF-1R using picropodophyllin in therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival; Int. J. Cancer, 121 1857 4) Razuvaev et al. (2007), The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling; J. Vasc. Surg., 46 108

(-)PPP Preparation Products And Raw materials

Raw materials

Preparation Products

(-)PPP Suppliers

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Affida new material science and technology center 		+undefined15081010295 2691956269@qq.com China 359 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
Xi'an Kono chem co., Ltd., 		029-86107037 13289246953 info@konochemical.com China 2995 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-519-519-85557386 marketing1@neostarunited.com China 8349 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Supplier Advantage
Shanghai Affida new material science and technology center 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Xi'an Kono chem co., Ltd., 		58
career henan chemical co 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58

View Lastest Price from (-)PPP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Picropodophyllotoxin pictures 2024-04-23 Picropodophyllotoxin
477-47-4
 US $0.00 / KG 1KG 99 10 tons Shanghai Affida new material science and technology center
(-)PPP pictures 2019-12-31 (-)PPP
477-47-4
 US $1.00 / g 1g 99% 200kg Career Henan Chemical Co
  • Picropodophyllotoxin pictures
  • Picropodophyllotoxin
    477-47-4
  • US $0.00 / KG
  • 99
  • Shanghai Affida new material science and technology center
  • (-)PPP pictures
  • (-)PPP
    477-47-4
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

(-)PPP Spectrum

(-)PPP(477-47-4)1HNMR

477-47-4((-)PPP)Related Search:

EUDESMINE (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside 28-deMethyl -β-aMyrone Gomisin M2 Benzoylgomisin O
Hydroxy(2-naphthyl)Methanephosphonic Acid ETHYL 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONATE (-)PPP 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Anwuligan
2-Methyl-3-[(3,4-methylenedioxy)phenyl]propionic acid, 98% Masoprocol 1,2,3,4-TETRAHYDRO-2-NAPHTHOIC ACID 7-HYDROXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID 6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID
2-NAPHTHALENECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-6-HYDROXY- 7-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID 6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBALDEHYDE

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PICROPODOPHYLLIN (-)PPP POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE) NSC 36407, Picropodophyllin, PPP, (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3μ,4μ:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one IGF-1R Inhibitor, PPP (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one NSC 36407 Pictopodophyllotoxin AXL 1717 AXL1717 AXL-1717 (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one Picropodophyllotoxin, >=98% Metacavir AXL1717 (Picropodophyllotoxin) IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem Picropodophyllin (AXL1717) Podophyllotoxin 5a-Epimer Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)- (-)PPP USP/EP/BP Picropodophyllin (Picropodophyllotoxin, AXL-1717 or PPP) (5R,5aS,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-te... (5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one (-)PPP Bitter Podophyllotoxin (5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one 477-47-4 Insulin-like Growth Factor-1 Receptor Inhibitor Picropodophyllin