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Anagrelide hydrochloride

Anagrelide hydrochloride
Anagrelide hydrochloride structure
CAS No.
58579-51-4
Chemical Name:
Anagrelide hydrochloride
Synonyms
RL 603;Xagrid;AGRYLIN;BL-4162A;BMY-26538-01;Agryline,HCl;ANAGRELIDE HCL;TroMboreductin;Xagrid hydrochloride;Agrylin hydrochloride
CBNumber:
CB8722913
Molecular Formula:
C10H8Cl3N3O
Formula Weight:
292.55
MOL File:
58579-51-4.mol

Anagrelide hydrochloride Properties

Melting point:
>280°C
storage temp. 
2-8°C
solubility 
DMSO: soluble1mg/mL, clear (warmed)
form 
powder
color 
white to beige
CAS DataBase Reference
58579-51-4(CAS DataBase Reference)
FDA UNII
VNS4435G39
NCI Drug Dictionary
Agrylin
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3

Anagrelide hydrochloride price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0846 Anagrelide hydrochloride ≥98% (HPLC) 58579-51-4 10mg $99.2 2021-03-22 Buy
Sigma-Aldrich SML0846 Anagrelide hydrochloride ≥98% (HPLC) 58579-51-4 50mg $400 2021-03-22 Buy
Cayman Chemical 21411 Anagrelide (hydrochloride) ≥95% 58579-51-4 50mg $213 2021-03-22 Buy
Cayman Chemical 21411 Anagrelide (hydrochloride) ≥95% 58579-51-4 10mg $50 2021-03-22 Buy
Cayman Chemical 21411 Anagrelide (hydrochloride) ≥95% 58579-51-4 100mg $375 2021-03-22 Buy

Anagrelide hydrochloride Chemical Properties,Uses,Production

Description

Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.

Chemical Properties

Off-White Powder

Originator

Roberts (US)

Uses

A phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic.

Uses

Signal Transduction Agents, Potent PDE3 inhibitor

Definition

ChEBI: The hydrochloride salt of anagrelide.

Manufacturing Process

6,7-Dicloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one was produced from 6-chloro-7-bromo-1,2,3,5-tetrahydroimidazo[2,1-b]quinozolin-2-one by substitution the bromine an equimolar quantity chlorine.
6-Chloro-7-bromo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one was produced next way: to a solution of 1.30 g (8 mmole) of anhydrous ferric chloride in 30 ml of nitromethane was added 1.30 g (5 mmole) of solid 6- chloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one and 0.80 g (5 mmole) of bromine. The system was stoppered, warmed to 50°C in an oil bath overnight, cooled to room temperature and the solvent removed in vacuo. The resulting solid was suspended in water (50 ml), the mixture was made basic (pH=10) with sodium bicarbonate and stirred at home temperature for 20 min. The solid was filtered under suction, washed with water, then isopropyl alcohol and dried yielding 1.19 g of 6-chloro-7-bromo- 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one (78% yield). Purification was effected by formation of the hydrochloride salt (mp 275°C) from acetonitrile.
6-Chloro-1,2,3,5,-tetrahydroimidazo[2,1-b]quinazolin-2-one was produced from 6-chloro-2-nitrobenzylchloride, ethylglycine hydrochloride and cyanogen bromide in 3 steps.

brand name

Agrylin (Shire).

Therapeutic Function

Platelet aggregation inhibitor

Biological Activity

Potent type III phosphodiesterase (PDE3) inhibitor (IC 50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Anagrelide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Anagrelide hydrochloride Suppliers

Global( 157)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17607 58

View Lastest Price from Anagrelide hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Anagrelide hydrochloride
58579-51-4
US $0.00-0.00 / KG 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
2019-10-30 Anagrelide hydrochloride
58579-51-4
US $0.00 / Kg/Drum 25Kg/Drum 98% 1ton HubeiwidelychemicaltechnologyCo.,Ltd
2019-07-06 Anagrelide hydrochloride
58579-51-4
US $2.00 / kg 1kg 99% 100kg career henan chemical co

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