ChemicalBook >> CAS DataBase List >>BIS(2,2,2-TRIFLUOROETHYL) ETHER

BIS(2,2,2-TRIFLUOROETHYL) ETHER

BIS(2,2,2-TRIFLUOROETHYL) ETHER structure

CAS No.: 333-36-8

Chemical Name:: BIS(2,2,2-TRIFLUOROETHYL) ETHER

Synonyms: HFE;SF6539;SKL232;Idoklon;skf6539;Flurotyl;Indiklon;Indoklon;SKF 6539;SK&F-6539

CBNumber:: CB8723208

Molecular Formula:: C4H4F6O

Molecular Weight:: 182.06

MDL Number:: MFCD00010604

MOL File:: 333-36-8.mol

MSDS File:: SDS

Last updated:2023-06-08 17:06:38

Request For Quotation

BIS(2,2,2-TRIFLUOROETHYL) ETHER Properties

Melting point	25°C
Boiling point	62-63 °C (lit.)
Density	1.404 g/mL at 25 °C (lit.)
refractive index	n20/D 1.300(lit.)
Flash point	35 °F
storage temp.	Flammables area
solubility	DMSO : ≥ 125 mg/mL (686.59 mM)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	1.41
Merck	14,4201
BRN	1811927
CAS DataBase Reference	333-36-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	9Z467FG2YK
EPA Substance Registry System	HFE-356mff2 (333-36-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

Hazard Codes

F,Xi,T

Risk Statements

11-36/37/38

Safety Statements

16-26-36

RIDADR

UN 3271 3/PG 2

WGK Germany

RTECS

KN3675000

Hazard Note

Flammable/Toxic/Convulsant

HazardClass

3.1

PackingGroup

HS Code

29091990

NFPA 704

	3
2		0

BIS(2,2,2-TRIFLUOROETHYL) ETHER price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	287571	Bis(2,2,2-trifluoroethyl) ether 98%	333-36-8	5g	$113	2024-03-01	Buy
TCI Chemical	B1293	Bis(2,2,2-trifluoroethyl) Ether >99.0%(GC)	333-36-8	1g	$59	2024-03-01	Buy
TCI Chemical	B1293	Bis(2,2,2-trifluoroethyl) Ether >99.0%(GC)	333-36-8	5g	$163	2024-03-01	Buy
TRC	B585665	Bis(2,2,2-trifluoroethyl) Ether	333-36-8	500mg	$70	2021-12-16	Buy
TRC	B585665	Bis(2,2,2-trifluoroethyl) Ether	333-36-8	50mg	$40	2021-12-16	Buy

Product number	Packaging	Price	Buy
287571	5g	$113	Buy
B1293	1g	$59	Buy
B1293	5g	$163	Buy
B585665	500mg	$70	Buy
B585665	50mg	$40	Buy

BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Originator

Indoklon ,Ohio Medical, US ,1964

Uses

Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.

Uses

Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.

Uses

5HT agonist

Definition

ChEBI: Flurotyl is an ether.

Manufacturing Process

23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).

brand name

Indoklon (Ohmeda).

Therapeutic Function

Central stimulant, Convulsant

BIS(2,2,2-TRIFLUOROETHYL) ETHER synthesis

Synthesis of BIS(2,2,2-TRIFLUOROETHYL) ETHER from 2,2,2-Trifluoroethanol

BIS(2,2,2-TRIFLUOROETHYL) ETHER Preparation Products And Raw materials

Raw materials

Tosyl chloride Sodium NSC 117816 sodium 2,2,2-trifluoroethanolate Diglycolic acid

Trifluoroacetic anhydride

1of2

Preparation Products

1,1,1,2-Tetrafluoroethane

BIS(2,2,2-TRIFLUOROETHYL) ETHER Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Allfluoro pharmaceutical co. ltd.	021-26137118 +8615821363818	sales@allfluoro.com	China	5791	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Zhengzhou Alfa Chemical Co.,Ltd	58
TargetMol Chemicals Inc.	58
Allfluoro pharmaceutical co. ltd.	58
CD Chemical Group Limited	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from BIS(2,2,2-TRIFLUOROETHYL) ETHER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-10-09	BIS(2,2,2-TRIFLUOROETHYL) ETHER 333-36-8	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

BIS(2,2,2-TRIFLUOROETHYL) ETHER
333-36-8
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

BIS(2,2,2-TRIFLUOROETHYL) ETHER Spectrum

BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)MS BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)¹HNMR BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)¹³CNMR BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)IR1 BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)Raman

333-36-8(BIS(2,2,2-TRIFLUOROETHYL) ETHER)Related Search:

2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE BIS(2,2,2-TRIFLUOROETHYL) ETHER Trifluoroacetic anhydride 2,2,2-TRIFLUOROETHYL TRICHLOROMETHANESULFONATE 6-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)TETRAHYDROPYRAN-2,4-DIOL

2-METHYL-2,4,6-TRIS(TRIFLUOROMETHYL)-2H-PYRAN PENTAFLUOROETHYL 2,2,2-TRIFLUOROETHYL ETHER MALEIC ACID BIS(2,2,2-TRIFLUOROETHYL)ETHER MALEIC ACID BIS(2,2,2-TRIFLUOROETHYL)ETHER 1,1,1,3,3,3-Hexafluoroisopropyl trifluoroacetate

PERFLUORO-T-BUTYL TRIFLUOROACETATE PERFLUORODIETHYL ETHER 2,2,X-TRIS(TRIFLUOROMETHYL)TRIFLUOROOXETANE 2-METHOXY-5-TETRADECYL-2,6-BIS-TRIFLUOROMETHYL-2,3-DIHYDRO-[1,3]OXAZIN-4-ONE 1-(DIETHOXYPHOSPHORYL)-2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE

PERFLUORO[2,5-DIMETHYL-2-(FLUOROCARBONYL)-4-OXO-1,3-DIOXOLANE] 6,7-BIS(DIMETHYLAMINO)-1,3-BIS(TRIFLUOROMETHYL)-1H,3H-BENZO[DE]ISOCHROMENE-1,3-DIOL 2,6-BIS(TRIFLUOROMETHYL)PYRAN-4-ONE

1of4

Di(2,2,2-trifluroethyl)ether Bis(2,2,2-trifluoroethyl) ether 99% Bis(2,2,2-trifluoroethyl)ether99% 2,2,2-TRIFLUOROETHYL ETHER 99% 2,2,2-Trifluoroethyl ether, Flurothyl 1,1'-Oxybis(2,2,2-trifluoroethane) 2,2,2-Trifluoroethyl ether,99% 1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxy)ethane 2-(2,2,2-Trifluoroethoxy)-1,1,1-trifluoroethane Bis(trifluoroethyl)ether Ethane, 1,1'-oxybis[2,2,2-trifluoro- Ether, bis(2,2,2-trifluoroethyl) ether,bis(2,2,2-trifluoroethyl) Fluoroethyl Fluorothyl Flurotyl Hexafluorodiethyl ether hexafluorodiethylether HFE Idoklon Indiklon Indoklon SF6539 SK&F-6539 SKF 6539 skf6539 2,2,2-TRIFLUOROETHYL ETHER BIS(2,2,2-TRIFLUOROETHYL) ETHER DI(2,2,2-TRIFLUOROETHYL)ETHER FLUROTHYL 2-trifluoroethyl) ether Bis(2,2,2-trifluoroethyl) Ether > 2,2,2-Trifluorodiethyl ether SKL232 inhibit,Fluorothyl,Inhibitor 333-36-8 CF3CH22O Building Blocks Oxygen Compounds Organic Building Blocks Ethers IMITREX