ChemicalBook >> CAS DataBase List >>4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline

CAS No.
35654-56-9
Chemical Name:
4-chloro-6,7-dimethoxyquinoline
Synonyms
4-Chloro-6,7-dimethoxyquioline;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;6,7-DIMETHOXY-4-CHLOROQUINOLINE;Quinoline, 4-chloro-6,7-dimethoxy-;4-Chloro-6,7-dimethoxyquinoline >
CBNumber:
CB8725015
Molecular Formula:
C11H10ClNO2
Molecular Weight:
223.66
MDL Number:
MFCD07778437
MOL File:
35654-56-9.mol
MSDS File:
SDS
Last updated:2023-12-26 17:07:23

4-chloro-6,7-dimethoxyquinoline Properties

Melting point 132.0 to 136.0 °C
Boiling point 325.2±37.0 °C(Predicted)
Density 1.265±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.95±0.30(Predicted)
color Pale Brown to Light Brown
InChI InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKey WRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILES N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference 35654-56-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  T
Risk Statements  25
Safety Statements  45-24/25
RIDADR  UN2811
HazardClass  IRRITANT
HS Code  29334900
NFPA 704
0
1 0

4-chloro-6,7-dimethoxyquinoline price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS007782 4-chloro-6,7-dimethoxyquinoline AldrichCPR 35654-56-9 250mg $104 2024-03-01 Buy
TCI Chemical C2938 4-Chloro-6,7-dimethoxyquinoline >98.0%(GC) 35654-56-9 5g $94 2024-03-01 Buy
TCI Chemical C2938 4-Chloro-6,7-dimethoxyquinoline >98.0%(GC) 35654-56-9 25g $376 2024-03-01 Buy
TRC C365930 4-Chloro-6,7-dimethoxyquinoline 35654-56-9 1g $220 2021-12-16 Buy
ChemScene CS-D1175 4-Chloro-6,7-dimethoxyquinoline 99.65% 35654-56-9 100g $228 2021-12-16 Buy
Product number Packaging Price Buy
CDS007782 250mg $104 Buy
C2938 5g $94 Buy
C2938 25g $376 Buy
C365930 1g $220 Buy
CS-D1175 100g $228 Buy

4-chloro-6,7-dimethoxyquinoline Chemical Properties,Uses,Production

Chemical Properties

Light brown powder

Uses

4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.

Application

4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.

Synthesis

With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.
4-chloro-6,7-dimethoxyquinoline synthesis

13425-93-9
35654-56-9
Synthesis of 4-chloro-6,7-dimethoxyquinoline from 4-Hydroxy-6,7-dimethoxyqunioline
Global( 384)Suppliers
Supplier Tel Email Country ProdList Advantage
Huanfu Industrial Co.,(Shanghai)Ltd.
+86-18001856580 +86-18001856580 2415195517@qq.com China 43 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5085 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58

View Lastest Price from 4-chloro-6,7-dimethoxyquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-6,7-dimethoxyquinoline pictures 2024-01-08 4-Chloro-6,7-dimethoxyquinoline
35654-56-9
US $2.00 / KG 1KG 99% 50000tons Wuhan Boyuan Import & Export Co., LTD
4-Chloro-6,7-dimethoxyquinoline pictures 2024-01-02 4-Chloro-6,7-dimethoxyquinoline
35654-56-9
US $200.00-1.00 / KG 1KG 99%, 99.5% Sublimated g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
6,7-dimethoxy-4-chloroquinoline pictures 2023-12-26 6,7-dimethoxy-4-chloroquinoline
35654-56-9
US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd

4-chloro-6,7-dimethoxyquinoline Spectrum

6,7-DIMETHOXY-4-CHLOROQUINOLINE 4-CHLORO-6,7-DIMETHOXYQUINOLINE Quinoline, 4-chloro-6,7-dimethoxy- 4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9) Cabozantinib 4-Chloroquinoline Impurity 4-Chloro-6,7-dimethoxyquinoline > oro-6,7-dimethoxyquinoL Cabozantinib Impurity 71 4-CHLORO-6,7-DIMETHOXYQUINOLINE ISO 9001:2015 REACH 4-CHLORO-6 7-DIMETHOXYQUINOLINE Cabozantinib Chloro Analog 4-Chloro-6,7-dimethoxyquioline 35654-56-9 Quinoline&Isoquinoline 35654-56-9