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Thiamine hydrochloride

Description References
Thiamine hydrochloride
Thiamine hydrochloride structure
CAS No.
67-03-8
Chemical Name:
Thiamine hydrochloride
Synonyms
thd;berin;bewon;biuno;VIT B1;bedome;bequin;beuion;bivita;beatine
CBNumber:
CB8741699
Molecular Formula:
C12H18Cl2N4OS
Formula Weight:
337.27
MOL File:
67-03-8.mol

Thiamine hydrochloride Properties

Melting point:
250 °C (dec.)(lit.)
Density 
1.3766 (rough estimate)
refractive index 
1.6000 (estimate)
FEMA 
3322 | THIAMINE HYDROCHLORIDE
Flash point:
9°C
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL at 20 °C, clear, colorless
pka
pKa 4.8 (Uncertain);9.0 (Uncertain)
form 
Crystalline Powder
color 
White to almost white
PH
2.7-3.3
Water Solubility 
1 g/mL
Sensitive 
Light Sensitive & Hygroscopic
JECFA Number
1030
Merck 
14,9295
BRN 
3851771
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.
CAS DataBase Reference
67-03-8(CAS DataBase Reference)
EPA Substance Registry System
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-5-(2-hydroxyethyl)- 4-methyl- chloride, monohydrochloride(67-03-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  22-24/25-37/39-26-36-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS  XI7350000
3-8-10
TSCA  Yes
HS Code  29362200
Toxicity LD50 in mice (mg/kg): 89.2 i.v.; 8224 orally (Winter)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Thiamine hydrochloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W332208 Thiamine hydrochloride ≥98%, FCC, FG 67-03-8 sample-k $40 2018-11-23 Buy
Sigma-Aldrich W332208 Thiamine hydrochloride ≥98%, FCC, FG 67-03-8 1kg-k $150 2018-11-23 Buy
TCI Chemical T0181 Thiamine Hydrochloride Hydrate >98.0%(HPLC)(T) 67-03-8 25g $29 2018-11-22 Buy
TCI Chemical T0181 Thiamine Hydrochloride Hydrate >98.0%(HPLC)(T) 67-03-8 100g $78 2018-11-22 Buy
Alfa Aesar A19560 Thiamine hydrochloride, 99% (dry wt.), may cont. up to 5% water 67-03-8 100g $51.3 2018-11-13 Buy

Thiamine hydrochloride Chemical Properties,Uses,Production

Description

Thiamine Hydrochloride is the hydrochloride salt form of thiamine (vitamin B1), a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Vitamin B1 helps prevent various health problems including heart damage.
Thiamine hydrochloride is used to prevent and treat thiamine deficiency states, which may occur as a result of inadequate nutrition or intestinal malabsorption. It is also used for the treatment of Wernicke-Korsakoff syndrome, beriberi and thiamine deficiency related to chronic alcoholism. Thiamine hydrochloride is used as a food additive to add brothy/meaty flavor to gravies or soups. It is used also as a food supplement and flavoring ingredient with a bitter taste.

References

[1] https://www.drugs.com
[2] Shmuel Yannai (2012) Dictionary of Food Compounds with CD-ROM, Second Edition
[3] https://www.medicines.org.uk

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Uses

Thiamine is the water-soluble vitamin b1, required for normal digestion and functioning of nerve tissues and in the prevention of beriberi. It also acts as a coenzyme in the metabolism of carbohydrates. During processing, the higher and longer the heating period, the greater the loss. The loss is reduced in the presence of acid. Thiamine hydrochloride and thiamine mononitrate are two available forms. The mononitrate form is less hygroscopic and more stable than the hydrochloride form, making it suitable for use in beverage powders. It is used in enriched flour and is found as thiamine mononitrite in frozen egg substitute and crackers.

Uses

Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.

Uses

A cofactor required for oxidation of carbohydrates and for the synthesis of ribose.

Definition

ChEBI: A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. The vitamin is destroyed by alkalies and alkaline drugs such as phenobarbital sodium and by oxidzing and reducing agents. When heated to decomposition it emits very toxic fumes of HCl, Cl-, SOx, and NOx.

Purification Methods

The hydrochloride crystallises from 95% EtOH (solubility is ca 1%). The monohydrate is dehydrated at 100o in vacuo over H2SO4, but is hygroscopic and picks up one molecule of H2O readily. It can be sterilised at 100o if the pH of the solution is below 5.5. The nitrate has m 196-200o(dec) and is more stable than the hydrochloride. The picrolonate crystallises from H2O and is dimorphic, m 164-165o and 228-229o(dec). [Todd & Bergel J Chem Soc 364, 367 1937, J Am Chem Soc 58 1063, 1504 1936, 59 526 1937, Beilstein 27 IV 1766.]

Thiamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Thiamine hydrochloride Suppliers

Global( 295)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1662 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20243 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 770 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3624 58

View Lastest Price from Thiamine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-04 Thiamine hydrochloride in stock Factory
67-03-8
US $1.00 / kg 1kg High quality purified manufacturer Top 3 production capacity Factory Chemwill Asia Co.,Ltd.
2018-07-26 Thiamine hydrochloride
67-03-8
US $1000.00 / KG 25KG 99% 10tons career henan chemical co
2018-07-23 Thiamine hydrochloride
67-03-8
US $50.00 / KG 100KG 99% 50tons career henan chemical co

Thiamine hydrochloride Spectrum


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