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4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

CAS No.
3680-69-1
Chemical Name:
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms
4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN;Nsc 64952;Brn 0607871;Tofacitinib-6;oro-7-deazapurine;Tofacitib impurity Q;Chloro-7-deazapurine;Tofatinib Impurity 6
CBNumber:
CB8742621
Molecular Formula:
C6H4ClN3
Molecular Weight:
153.57
MDL Number:
MFCD01686865
MOL File:
3680-69-1.mol
MSDS File:
SDS
Last updated:2023-12-20 20:39:53

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point 188-194 °C
Boiling point 289.2±50.0 °C(Predicted)
Density 1.61±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in DMSO, ethyl acetate and methanol.
form Crystalline Powder
pka 11.42±0.20(Predicted)
color White to tan
InChI InChI=1S/C6H4ClN3/c7-5-4-1-2-8-6(4)10-3-9-5/h1-3H,(H,8,9,10)
InChIKey BPTCCCTWWAUJRK-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C2C=CNC2=N1
LogP 0.858 at 30℃
CAS DataBase Reference 3680-69-1(CAS DataBase Reference)
FDA UNII 9VV5MK5RX3

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xi,T,Xn
Risk Statements  36/37/38-25-20/21/22
Safety Statements  26-37-45-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UY9360000
TSCA  No
HazardClass  IRRITANT
PackingGroup 
HS Code  29335990
NFPA 704
1
3 0

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 699489 6-Chloro-7-deazapurine 97% 3680-69-1 1g $15.6 2024-03-01 Buy
TCI Chemical C2306 6-Chloro-7-deazapurine >98.0%(GC)(T) 3680-69-1 1g $128 2024-03-01 Buy
TCI Chemical C2306 6-Chloro-7-deazapurine >98.0%(GC)(T) 3680-69-1 5g $396 2024-03-01 Buy
Alfa Aesar B25713 6-Chloro-7-deazapurine, 98% 3680-69-1 1g $189.65 2024-03-01 Buy
Alfa Aesar B25713 6-Chloro-7-deazapurine, 98% 3680-69-1 5g $734.65 2024-03-01 Buy
Product number Packaging Price Buy
699489 1g $15.6 Buy
C2306 1g $128 Buy
C2306 5g $396 Buy
B25713 1g $189.65 Buy
B25713 5g $734.65 Buy

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production

Uses

4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response.

Chemical Properties

Lightbrown to brown crystalline powder

Uses

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is used in the manufacture of Tofacitinib citrate.

Synthesis

The preparation process of pyrimidine includes the first α -alkylation reaction between diethyl malonate and allyl bromide, and the subsequent cyclization reaction with amidine to obtain a six-membered ring of bislactam. The chlorination of carbonyl with phosphorus oxychloride to obtain dichloro pyrimidine ring, followed by the oxidation of the terminal double bond with potassium osmate hydrate and sodium periodate to obtain the aldehyde group. The final reaction with ammonia water to produce SNAr/cyclization reaction, a five-step reaction, total yield of 45.8% to obtain 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

3680-71-5
3680-69-1
Synthesis of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine from Pyrrolo[2,3-d]pyrimidin-4-ol
Global( 907)Suppliers
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Shanghai Boc Chemical Co., Ltd.
+8618721111801 shangli@bocchem.com CHINA 138 58
Shanghai Rochi Pharmaceutical Co.,Ltd.
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Hangzhou Qiwei Pharmatech Co.,Ltd
13282840061 mw@qwpharmatech.com China 109 58
Huanfu Industrial Co.,(Shanghai)Ltd.
+86-18001856580 +86-18001856580 2415195517@qq.com China 43 58
Aceschem Inc.
+1-817863-6948 +1-(817)863-6948 sales@aceschem.com United States 19639 58
Wuhan Boyuan Import & Export Co., LTD
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Hangzhou ICH Biofarm Co., Ltd
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Anhui Lianchuang Biological Medicine Co.,Ltd
+8619355958469 sales7@lcywhx.com China 86 58

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View Lastest Price from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloropyrrolo[2,3-d]pyrimidine pictures 2024-03-19 4-Chloropyrrolo[2,3-d]pyrimidine
3680-69-1
US $22.00-20.00 / KG 100 mkg 99% 20mt Jinan Finer Chemical Co., Ltd
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine pictures 2024-01-08 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
3680-69-1
US $9.00 / KG 1KG 99% 50000tons Wuhan Boyuan Import & Export Co., LTD
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine pictures 2023-12-20 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
3680-69-1
US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
4-chloro-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine 4-chloro-7H-pyrrolo[2,3-d]pyrimidine(SALTDATA: FREE) 4-Chloropyrrolo[2,3-d]pyriMidine 6-Chloro-7-deazapurine 7H-pyrrolo[2,3-d]pyriMidine, 6-Chloro-7-deazapurine 4-chloro-7H-pyrollo[2,3d]pyriMidine 4-Methyl-1,3-thiazole-2,5-diaMine Tofacitinib interMediate C 6-Chloro-7-deazapurine ,98% 4-chloro-7H-pyrrolo[2,3-d]pyrimidine/6-Chloro-7-deazapurine Nsc 64952 Brn 0607871 7H-pyrrolo[2,3-d]pyrimidine, 4-chloro- Tofacitinib Impurity Q 4-Chloropyrro[2,3-d] pyriMidine 4-Chloro-(2,3-d)pyrimidine 4-chloro-7H-pyrrolo[3,2-e]pyrimidine Tofacitinib int-2 4-Chloropyrrolo[2,3-d]pyrimidine 4-Chloropyrrolo[2,3-d]pyrimidine 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine 3-d)pyrimidine,4-chloro-7h-pyrrolo( 4-METHYL-2,5-DIAMINETHIAZOLE 6-Chloro-7-deazapurine, 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine 6-CHLORO-7-DEAZAPURINE 98.5% 4-CHLORO-4H-PYRROLO[2,3-D]PYRIMIDINE 6-Chloro-7-deazapurin 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine4-Chloropyrrolo[2,3-d]pyrimidine 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE Tofacitib impurity Q oro-7-deazapurine 6-Chloro-7-deazapurine> Chloro-7-deazapurine Tofacitinib-6 Tofacitinib citrate intermediate 6-CHLORO-7-DEAZAPURINE 4-CHLORO-7 4-chloropyrrolopyrimidine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine(Cas number:3680-69-1) 4-Chloro-7H-pyrrolo[2,3-d]pyridine 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine USP/EP/BP -Chloro-7H-pyrrolo[2,3-d]pyrimidine -Chloropyrrolo(2,3-d)pyrimidine Azilsartan medoxomil impurity348 4-Chloro-1H-pyrrolo(2,3-d)pyrimidine(3680-69-1) 4-Chloro-7H-pyrrolo[2,3-d]py 6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN 6-CHLORO-7-DEAZAPURINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 4-chloropyrropyrimidine Tofatinib Impurity 6 4-Chloro-7H-pyrrolo4-Chloro-7H-pyrrolo[2,3-d]pyrimidine[2,3-d]pyrimidine Baricitinib intermediate 3 4-Chloropyrrolidone pyrimidine 3680-69-1 Fused Ring Systems Heterocyclic Building Blocks Heterocycle-Pyrimidine series Baricitinib Ruxolitinib