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4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Uses
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine structure
CAS No.
3680-69-1
Chemical Name:
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms
Nsc 64952;Brn 0607871;Tofacitinib-6;TOFACITINIB-6;oro-7-deazapurine;Tofacitib impurity Q;Chloro-7-deazapurine;Tofacitinib Impurity Q;6-Chloro-7-deazapurin ;6-CHLORO-7-DEAZAPURINE
CBNumber:
CB8742621
Molecular Formula:
C6H4ClN3
Formula Weight:
153.57
MOL File:
3680-69-1.mol

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point:
183-184°C
Boiling point:
289.2±50.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
Room temperature.
solubility 
Soluble in DMSO, ethyl acetate and methanol.
pka
11.42±0.20(Predicted)
form 
Crystalline Powder
color 
White to tan
InChIKey
BPTCCCTWWAUJRK-UHFFFAOYSA-N
CAS DataBase Reference
3680-69-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07
Signal word  Danger
Hazard statements  H335-H315-H319-H301
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P301+P310-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,T,Xn
Risk Statements  36/37/38-25-20/21/22
Safety Statements  26-37-45-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UY9360000
TSCA  No
HazardClass  IRRITANT
PackingGroup 
HS Code  29335990

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 699489 6-Chloro-7-deazapurine 97% 3680-69-1 1g $110 2019-12-02 Buy
TCI Chemical C2306 6-Chloro-7-deazapurine >98.0%(GC)(T) 3680-69-1 1g $124 2020-06-24 Buy
TCI Chemical C2306 6-Chloro-7-deazapurine >98.0%(GC)(T) 3680-69-1 5g $432 2020-06-24 Buy
Alfa Aesar B25713 6-Chloro-7-deazapurine, 98% 3680-69-1 5g $737 2020-06-24 Buy
Alfa Aesar B25713 6-Chloro-7-deazapurine, 98% 3680-69-1 1g $188 2020-06-24 Buy

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production

Uses

4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response.

Chemical Properties

Lightbrown to brown crystalline powder

Uses

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is used in the manufacture of Tofacitinib citrate.

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products


4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Global( 570)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Nanjing Baifuli Technology Co., Ltd.
+86-15335185688
sales@unisyn.cn CHINA 332 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21836 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Hi-Tech Chemistry Corp
0519-86626038
yuhh@hitechem.com CHINA 811 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3269 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60

Related articles


View Lastest Price from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-21 4-Chloropyrrolo[2,3-d]pyrimidine
3680-69-1
US $22.00-20.00 / KG 100 mkg 99% 20mt Jinan Finer Chemical Co., Ltd
2019-07-03 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
3680-69-1
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-12-20 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
3680-69-1
US $1.00 / kg 1kg 95%-99% 100kg career henan chemical co

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