12-Crown-4
- CAS No.
- 294-93-9
- Chemical Name:
- 12-Crown-4
- Synonyms
- Crown;1,4,7,10-TETRAOXACYCLODODECANE;12-CROWN 4-ETHER;Eoct;12C4;12 C 4;12-C-4;12-CROWN-4;12-Crown-4,97%;LITHIUM IONOPHORE V
- CBNumber:
- CB8752442
- Molecular Formula:
- C8H16O4
- Molecular Weight:
- 176.21
- MDL Number:
- MFCD00005103
- MOL File:
- 294-93-9.mol
- MSDS File:
- SDS
Melting point | 16 °C (lit.) |
---|---|
Boiling point | 61-70 °C/0.5 mmHg (lit.) |
Density | 1.089 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | Liquid After Melting |
Specific Gravity | 1.115 (20℃) |
color | Clear colorless to slightly yellow |
Water Solubility | MISCIBLE |
Sensitive | Air Sensitive |
BRN | 1363064 |
CAS DataBase Reference | 294-93-9(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | K6069P2C2A |
NIST Chemistry Reference | 12-Crown-4(294-93-9) |
EPA Substance Registry System | 1,4,7,10-Tetraoxacyclododecane (294-93-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H330 | |||||||||
Precautionary statements | P304+P340+P310 | |||||||||
Hazard Codes | T+,Xn,Xi | |||||||||
Risk Statements | 26-36/37/38-20/21/22 | |||||||||
Safety Statements | 28-36/37-45-36-26 | |||||||||
RIDADR | UN 2810 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | XF0550000 | |||||||||
F | 3-9-23 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29329995 | |||||||||
Toxicity | LD50 oral in rat: 2830mg/kg | |||||||||
NFPA 704 |
|
12-Crown-4 price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 194905 | 12-Crown-4 98% | 294-93-9 | 1g | $62.5 | 2024-03-01 | Buy |
Sigma-Aldrich | 194905 | 12-Crown-4 98% | 294-93-9 | 5g | $148 | 2024-03-01 | Buy |
TCI Chemical | C0858 | 12-Crown 4-Ether >95.0%(GC) | 294-93-9 | 1mL | $54 | 2024-03-01 | Buy |
TCI Chemical | C0858 | 12-Crown 4-Ether >95.0%(GC) | 294-93-9 | 5mL | $177 | 2024-03-01 | Buy |
Alfa Aesar | A11972 | 12-Crown-4, 98% | 294-93-9 | 1g | $76.65 | 2024-03-01 | Buy |
12-Crown-4 Chemical Properties,Uses,Production
Chemical Properties
clear colorless to slightly yellow liquid after
Uses
It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.
Uses
12-Crown-4 can be used as:
- A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
- As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
- A phase transfer catalyst in organic synthesis.
Definition
ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.
Synthesis Reference(s)
Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1
General Description
12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.
Purification Methods
The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]
12-Crown-4 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8905 | 58 |
View Lastest Price from 12-Crown-4 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-02 | 12-Crown-4
294-93-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-06 | 12-Crown-4
294-93-9
|
US $7.00 / kg | 1kg | 99% | 100KG | Career Henan Chemical Co | ||
2019-07-06 | 12-Crown-4
294-93-9
|
US $7.00 / kg | 1kg | 99% | 100KG | Career Henan Chemical Co |
- 12-Crown-4
294-93-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- 12-Crown-4
294-93-9
- US $7.00 / kg
- 99%
- Career Henan Chemical Co
- 12-Crown-4
294-93-9
- US $7.00 / kg
- 99%
- Career Henan Chemical Co
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