ChemicalBook >> CAS DataBase List >>Methyl coumalate

Methyl coumalate

CAS No.
6018-41-3
Chemical Name:
Methyl coumalate
Synonyms
METHYL 2-OXO-2H-PYRAN-5-CARBOXYLATE;Coumalic acid methyl ester;Methyl coumaric acid;METHYL COUMALATE;TIMTEC-BB SBB000117;Methyl coumalate 98%;Methyl Coumalate >5-(Carbomethoxy)-2-pyrone;Methyl 2-pyrone-5-carboxylate;METHYL PYR-2-ONE-5-CARBOXYLATE
CBNumber:
CB8755382
Molecular Formula:
C7H6O4
Molecular Weight:
154.12
MDL Number:
MFCD00010120
MOL File:
6018-41-3.mol
MSDS File:
SDS
Last updated:2023-05-25 18:01:21

Methyl coumalate Properties

Melting point 65-67 °C (lit.)
Boiling point 178-180 °C/60 mmHg (lit.)
Density 1.1993 (rough estimate)
refractive index 1.4300 (estimate)
Flash point 178-180°C/60mm
storage temp. Inert atmosphere,Room Temperature
solubility Freely soluble in dichloromethane.
form powder to crystal
color White to Orange to Green
Merck 14,2557
BRN 126301
LogP -0.660 (est)
CAS DataBase Reference 6018-41-3(CAS DataBase Reference)
FDA UNII 1S7TMF0R8T
NIST Chemistry Reference 2H-Pyran-5-carboxylic acid, 2-oxo-, methyl ester(6018-41-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H317-H334-H351b
Precautionary statements  P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
WGK Germany  3
HS Code  2932209090
NFPA 704
1
0 0

Methyl coumalate price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 261432 Methyl coumalate 98% 6018-41-3 10g $441 2024-03-01 Buy
TCI Chemical C1734 Methyl Coumalate >96.0%(GC) 6018-41-3 5g $85 2024-03-01 Buy
TCI Chemical C1734 Methyl Coumalate >96.0%(GC) 6018-41-3 25g $278 2024-03-01 Buy
Alfa Aesar B25330 Methyl coumalate, 98% 6018-41-3 2g $47.65 2024-03-01 Buy
Alfa Aesar B25330 Methyl coumalate, 98% 6018-41-3 10g $165.65 2024-03-01 Buy
Product number Packaging Price Buy
261432 10g $441 Buy
C1734 5g $85 Buy
C1734 25g $278 Buy
B25330 2g $47.65 Buy
B25330 10g $165.65 Buy

Methyl coumalate Chemical Properties,Uses,Production

Uses

α, β-Unsaturated ketone Methyl Coumalate showed cytotoxicity against human normal gingival fibroblast cells and oral squamous cell carcinoma cell line-2.

Uses

Methyl coumalate has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates. It was also used in the preparation of 7-carboxyquinolizinium derivatives.

Uses

Methyl coumalate is a 2-pyrone and acts as dienophile in Diels-Alder reaction. It reacts with 1,3-butadienes at 100°C to yield tetrahydrocoumarins and 4-methoxycarbonyltricyclo[3.2.1.02,7]octenes. It also reacts with cyclohexadiene to afford tetrahydronaphthalene-2-carboxylate. It undergoes Diels-Alder reaction with unactivated alkenes to afford para-substituted adducts. It has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates. It was also used in the preparation of 7-carboxyquinolizinium derivatives.

General Description

Methyl coumalate is a 2-pyrone and acts as dienophile in Diels-Alder reaction. It reacts with 1,3-butadienes at 100°C to yield tetrahydrocoumarins and 4-methoxycarbonyltricyclo[3.2.1.02,7]octenes. It also reacts with cyclohexadiene to afford tetrahydronaphthalene-2-carboxylate. It undergoes Diels-Alder reaction with unactivated alkenes to afford para-substituted adducts.

Methyl coumalate Preparation Products And Raw materials

Global( 172)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387 1057@dideu.com China 3979 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 9802 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9340 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58

View Lastest Price from Methyl coumalate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl coumaric acid pictures 2023-05-04 Methyl coumaric acid
6018-41-3
US $48.00-40.00 / KG 1KG 99% 200tons Guangzhou Sunton Biotechnology Co., Ltd.
Methyl coumalate pictures 2021-07-13 Methyl coumalate
6018-41-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Methyl coumalate pictures 2021-07-10 Methyl coumalate
6018-41-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Methyl coumalate pictures
  • Methyl coumalate
    6018-41-3
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Methyl coumalate pictures
  • Methyl coumalate
    6018-41-3
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
Methyl 2-oxo-2H-pyran-5-carboxylate, Methyl 2-pyrone-5-carboxylate 2-Oxo-2H-pyran-5-carboxylic acid methyl ester 2-Oxopyran-5-carboxylic Acid Acid Methyl Ester 2-Pyrone-5-carboxylic Acid Methyl Ester Methyl 2-Pyrone-5-carboxylate Coumalic acid methyl ester 2H-Pyran-5-carboxylic acid, 2-oxo-, Methyl ester Coumalic Acid Methyl Ester 2-Oxopyran-5-carboxylic Acid Methyl Ester Methyl 2-Oxopyran-5-carboxylate 2-Pyrone-5-carboxylic Acid Methyl Ester Methyl 2-Pyrone-5-carboxylate methyl 6-oxopyran-3-carboxylate 5-(Carbomethoxy)-2-pyrone 6-Oxo-6H-pyran-3-carboxylicacidmethylester Glutaconic acid, 4-(hydroxymethylene)-, delta-lactone, methyl ester Methyl 2-pyrone-5-carboxylate TIMTEC-BB SBB000117 Methyl coumalate 98% METHYL 2H-PYRAN-2-OXO-5-CARBOXYLATE METHYL COUMALATE METHYL PYR-2-ONE-5-CARBOXYLATE Methyl 2-oxo-2H-pyran-5-carboxylate 97% Methyl pyr-2-one-5-carboxylate,Methyl coumalate Methyl Coumalate > Methyl 2-Oxopyran-5-carboxylate 2-Oxopyran-5-carboxylic Acid Methyl Ester Methyl coumalate ISO 9001:2015 REACH Coumalic acid methyl ester METHYL 2-OXO-2H-PYRAN-5-CARBOXYLATE Methyl coumaric acid 6018-41-3 25898-60-7 Heterocyclic Building Blocks Pyrans Building Blocks Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Ring Systems Heterocycles series Esters