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Loperamide hydrochloride

Loperamide hydrochloride
Loperamide hydrochloride structure
CAS No.
34552-83-5
Chemical Name:
Loperamide hydrochloride
Synonyms
blox;pj185;Imosse;r18553;Clalet;imosec;loperyl;lopemin;lopemid;Imossel
CBNumber:
CB8758181
Molecular Formula:
C29H34Cl2N2O2
Formula Weight:
513.5
MOL File:
34552-83-5.mol

Loperamide hydrochloride Properties

Melting point:
223-225°C
Density 
1.1905 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Store at RT
solubility 
Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
pka
8.66(at 25℃)
form 
neat
Merck 
14,5571
CAS DataBase Reference
34552-83-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  TM4960000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29333990
Toxicity LD50 in mice (mg/kg): 75 s.c.; 28 i.p.; 105 orally; in rats (mg/kg): 185 orally (Niemegeers)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Loperamide hydrochloride price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34014 Loperamide hydrochloride VETRANAL , analytical standard 34552-83-5 100mg-r $42 2018-11-13 Buy
Sigma-Aldrich 1370000 Loperamide hydrochloride United States Pharmacopeia (USP) Reference Standard 34552-83-5 200mg $348 2018-11-13 Buy
TCI Chemical L0154 Loperamide Hydrochloride >98.0%(T)(HPLC) 34552-83-5 5g $79 2018-11-22 Buy
TCI Chemical L0154 Loperamide Hydrochloride >98.0%(T)(HPLC) 34552-83-5 25g $240 2018-11-22 Buy
Alfa Aesar J60168 Loperamide hydrochloride, 98+% 34552-83-5 25g $381 2018-11-13 Buy

Loperamide hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Ca channel blocker

Uses

Loperamide hydrochloride is a Ca2+ channel protein inhibitor and MOR activator.

Uses

Labeled Loperamide, which is used as an antidiarrheal

Definition

ChEBI: A hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

brand name

Imodium (Janssen); Imodium (McNeil).

Biological Activity

High affinity μ -opioid receptor agonist with peripheral selectivity (K i values are 2, 48 and 1156 nM for μ -, δ - and κ -opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca 2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca 2+ channels and at higher concentrations it reduces Ca 2+ flux through NMDA receptor operated channels.

Loperamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Loperamide hydrochloride Suppliers

Global( 219)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Qufu Haida Tiancheng Biochemical Co., Ltd. +86 (537) 456-7186 / +86 15998733238
qfhdtc@126.com China 54 55
WUHAN YUANCHENG GONGCHUANG TECHNOLOGY CO.,LTD 18121080540
hyt@ycphar.com China 2033 55
Guangzhou Kafen Biotech Co.,Ltd 18029243487 QQ:2355327168
020-31121510 gy@yccreate.com China 4848 55

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