HEXESTROL | 84-16-2

HEXESTROL Properties

Melting point	186 °C
Boiling point	353.48°C (rough estimate)
Density	1.093
refractive index	1.4800 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	almost transparency in Methanol
pka	9.80±0.26(Predicted)
color	White to Almost white
Merck	14,4701
BRN	3209460
InChI	InChI=1/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3/t17-,18+
InChIKey	PBBGSZCBWVPOOL-HDICACEKNA-N
SMILES	[C@@H](C1=CC=C(O)C=C1)(CC)[C@@H](C1=CC=C(O)C=C1)CC \|&1:0,10,r\|
CAS DataBase Reference	84-16-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	10BI795R7D

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H350
Precautionary statements	P201-P202-P280-P308+P313-P405-P501
Hazard Codes	T
Risk Statements	45
Safety Statements	53-45
WGK Germany	2
RTECS	SL0560850
HS Code	2907.29.9000

HEXESTROL price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H7753	Hexestrol analytical standard	84-16-2	1g	$73.9	2022-05-15	Buy
Sigma-Aldrich	H7753	Hexestrol analytical standard	84-16-2	5g	$353	2022-05-15	Buy
TCI Chemical	D0494	Hexestrol >98.0%(GC)	84-16-2	1g	$57	2024-03-01	Buy
TCI Chemical	D0494	Hexestrol >98.0%(GC)	84-16-2	10g	$261	2024-03-01	Buy
Alfa Aesar	J60889	Hexestrol, 98+%	84-16-2	1g	$60.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
H7753	1g	$73.9	Buy
H7753	5g	$353	Buy
D0494	1g	$57	Buy
D0494	10g	$261	Buy
J60889	1g	$60.65	Buy

HEXESTROL Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Estra Plex,Rowell,US,1956

Uses

Nonsteroidal synthetic estrogen

Uses

Estrogen; antineoplastic (hormonal).

Manufacturing Process

50 parts by weight of p-hydroxypropiophenone are dissolved in 200 parts by weight of a 12.5% solution of caustic soda and shaken with 350 parts by weight of 3% sodium amalgam. The sodium salt of the pinacol thereby precipitating is reacted with glacial acetic acid, whereby the free pinacol is obtained (MP 205°C to 210°C, after purification 215°C to 217°C). The yield amounts to 95% of the theoretical. The pinacol is suspended in ether and gaseous hydrogen chloride introduced, whereby water separates and the pinacolin formed is dissolved in the ether, from which it is obtained by evaporation as a viscous oil (diacetate of MP 91°C). The yield is quantitative.
40 parts by weight of pinacolin are dissolved in ethyl alcohol and gradually treated with 80 parts by weight of sodium under reflux. The solution is decomposed with water and the pinacolin alcohol formed extracted from the neutalized solution with ether. The pinacolin alcohol is a viscous oil which is characterized by a dibenzoate of MP 172°C. The yield is 95% of the theoretical.
30 parts by weight of pinacolin alcohol are dissolved in 25 parts by weight of glacial acetic acid and heated for 30 minutes to 135°C to 140°C after having added 20 parts by weight of hydroiodic acid (specific gravity = 1.94) and 5 parts by weight of red phosphorus. The whole is filtered, the solution poured into water, extracted with ether and the ether solution washed with bicarbonate. The oil remaining after distilling off the ether is taken up in chloroform, whereby hexoestrol [α,β-(p,p-dihydroxy-diphenyl)-α,β-diethylethane] crystallizes out. MP after recrystallization from benzene: 185°C. Yield: 20%.

Therapeutic Function

Estrogen

Purification Methods

Crystallise meso-Hexestero from *benzene or aqueous EtOH (m 185-188o). The meso-dibenzoyl derivative has m 236-237o. The 3RS,4RS(±)-racemate [5776-72-7] crystallises from pet ether, *C6H6/pet ether, Et2O/pet ether, or MeOH/H2O and has m 128-129o . The (±)-dibenzoyl derivative has m 123-124o . The 3R,4R(+)-isomer [26614-21-1] and 3S,4S(-)-isomer [26614-22-2] crystallise from Et2O/pet ether with m 80 -80.5o and have [] D (+) and (-) 17.7o (c 5, EtOH). Their dibenzoyl derivatives have m 116.5o .[Beilstein 6 III 5503, 6 IV 6761.] They have estrogenic activity where optically active forms are more potent and they have antineoplastic activity. [Aboul-Enein et al. Anal Profiles Drug Subst 11 347 1982, J Am Chem Soc 65 4911941.]

HEXESTROL Preparation Products And Raw materials

Raw materials

cis-Anethol Phosphorus 4'-Hydroxypropiophenone Hydriodic acid Hydrochloric acid

SODIUM MERCURY AMALGAM

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Preparation Products

HEXESTROL Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TCI Europe	320-37350700	sales@tcieurope.eu	Europe	23680	75
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58

Supplier	Advantage
TCI Europe	75
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58

View Lastest Price from HEXESTROL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-17	HEXESTROL 84-16-2	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2021-11-02	HEXESTROL 84-16-2	US $1300.00 / KG	1G	USP	100KGS	Baoji Guokang Healthchem co.,ltd
2021-07-13	HEXESTROL 84-16-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

HEXESTROL
84-16-2
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

HEXESTROL
84-16-2
US $1300.00 / KG
USP
Baoji Guokang Healthchem co.,ltd

HEXESTROL
84-16-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

HEXESTROL Spectrum

HEXESTROL(84-16-2)¹HNMR

84-16-2(HEXESTROL)Related Search:

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Phenyl bromoacetate HEXOESTROL HEXESTROL

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Hexanoestrol Solution, 100ppm Hexestrol solution,100ppm Hexoestrol Hexestrol(Bibenzyl) 4,4'-(hexane-3,4-diyl)diphenol Phenol,4,4'-[(1R,2S)-1,2-diethyl-1,2-ethanediyl]bis-, rel- 4,4’-(1,2-diethyl-1,2-ethanediyl)bis-,(r*,s*)-pheno 4,4’-(1,2-diethyl-1,2-ethanediyl)bis-phenol 4,4’-(1,2-diethyl-1,2-ethylenediyl)bis-,(r*,s*)-pheno 4,4’-dihydroxy-alpha,beta-diethyldiphenylethane 4,4’-dihydroxy-gamma,delta-diphenylhexane 4,4'-Dihydroxy-alpha,beta-diethyldiphenylethane 4,4'-Dihydroxy-gamma,delta-diphenylhexane 4’-(1,2-diethylethylene)di-meso-pheno alpha,alpha’-diethyl-4,4’-dihydroxy-bibenzy 3,4-bis(p-hydroxyphenyl)-hexan 4,4'-(1,2-DIETHYLETHYLENE)DIPHENOL MESO-3,4-BIS[4-HYDROXYPHENYL]-HEXANE DIHYDRODIETHYLSTILBESTROL HEXOESTROLUM HEXOESTROL (R*,S*)-4,4'-(1,2-diethylethylene)bis(phenol) HEXESTEROL VETRANAL, 250 MG DL-HEXESTROL MESO-HEXOESTROL 4,4''-(1,2-DIETHYLETHYLENE)DIPHENOL 98+% rel-4,4'-[(1R,2S)-1,2-Diethyl-1,2-ethanediyl]bisphenol 4,4μ-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol [CH(C2H5)C6H4OH]2 3,4-BIS-(P-HYDROXYPHENYL)-HEXANE 3,4-DI(P-HYDROXYPHENYL)HEXANE alpha,alpha’-diethyl-4,4’dihydroxy-bibenzy Bibenzyl, alpha,alpha'-diethyl-4,4'-dihydroxy- Cycloestrol dihydro-stilbestro Dihydrostilbestrol Estra-Plex Estrifar Estronal Extra-Plex gamma,delta-Di(p-hydroxyphenyl)-hexane Hexane, 3,4-bis(p-hydroxyphenyl)- Hexanoestrol Hexestrofen Hexron Hormoestrol meso-3,4-Bis(p-hydroxyphenyl)-n-hexane meso-3,4-Di(p-hydroxyphenyl)-n-hexane meso-Hexestrol NSC-9894 Phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (R*,S*)- Phenol, 4,4'-(1,2-diethyl-1,2-ethylenediyl)bis-, (R*,S*)- Phenol, 4,4'-(1,2-diethylethylene)di- Phenol, 4,4'-(1,2-diethylethylene)di-, meso- Sinestrol Stilbestrol, dihydro- Synestrol Synoestrol