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PROTEASOME INHIBITOR I

PROTEASOME INHIBITOR I structure

CAS No.: 158442-41-2

Chemical Name:: PROTEASOME INHIBITOR I

Synonyms: PSI;N-Cb;CS-1340;Z-IE(OTBU)AL-CHO;PROTEASOME INHIBITOR I;ProteasoMe Inhibitor 1;PROTEASOME INHIBITOR PSI;M.W. 618.77 C32H50N4O8;Z-ILE-GLU(OBUT)-ALA-LEU-H;Z-ILE-GLU(OTBU)-ALA-LEU-CHO

CBNumber:: CB8781378

Molecular Formula:: C32H50N4O8

Molecular Weight:: 618.76

MDL Number:: MFCD00671409

MOL File:: 158442-41-2.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:10

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PROTEASOME INHIBITOR I Properties

Boiling point	844.2±65.0 °C(Predicted)
Density	1.121±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	≥30.6 mg/mL in DMSO; insoluble in H2O; ≥48.7 mg/mL in EtOH
form	solid
pka	11.12±0.46(Predicted)

SAFETY

Risk and Safety Statements

WGK Germany	3

PROTEASOME INHIBITOR I price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	539160	Proteasome Inhibitor I The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.		1MG	$113	2024-03-01	Buy
Sigma-Aldrich	539160	Proteasome Inhibitor I The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.		5MG	$360	2024-03-01	Buy
Usbiological	256358	PSI	158442-41-2	5mg	$480	2021-12-16	Buy
TRC	P838815	ProteasomeInhibitor1	158442-41-2	100mg	$4675	2021-12-16	Buy
Medical Isotopes, Inc.	66848	ProteasomeInhibitor1	158442-41-2	100mg	$5250	2021-12-16	Buy

Product number	Packaging	Price	Buy
539160	1MG	$113	Buy
539160	5MG	$360	Buy
256358	5mg	$480	Buy
P838815	100mg	$4675	Buy
66848	100mg	$5250	Buy

PROTEASOME INHIBITOR I Chemical Properties,Uses,Production

Uses

Proteasome Inhibitor 1, is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It is also shown to be used for the treatment of cancer, especially multiple myeloma. Proteasome inhibitors also induce apoptosis and reduce viral replication in primary effusion lymphoma cells.

Biological Activity

zie(otbu)al-cho (psi)1 have been shown to inhibit the proteasome activities in a variety of cell types.peptide aldehyde, psi (z-ile-glu(otbu)-ala-leu-al), inhibits the proteasome 10-fold better than calpain but is less potent than mg1322. since mg132, psi, mg115 (z-leu-leu-nval-al) and alln can all inhibit calpains and various lysosomal cathepsins in addition to the proteasome, when using these inhibitors in cell culture it is important to perform control experiments to con¢rm that the observed e¡ects are due to the inhibition of the proteasome. first, one can use agents, which block intracellular cysteine proteases, but do not inhibit proteasomes3. such inhibitors are z-leu-leu- al, and e-64 for calpains4, and weak bases such as chloroquine and e-64 for lysosomal proteolysis . in yeast, where digestive vacuoles contain mainly serine, not cysteine, proteases, phenylmethylsulfonyl £uoride can be used to inhibit these enzymes without affecting proteasomes5.despite the availability of these inhibitors, mg132, due to its low cost and the rapid reversibility of its action, still remains, in our opinion, the first choice to study proteasome involvement in a process in cell cultures or tissues, if appropriate controls are used. as the most potent and selective of commercially available aldehydes, mg132 is preferable to alln, mg115 (z-leu-leu-nval-al), or even psi. on the other hand, the least selective inhibitor, alln, because of its ability to inhibit most major pro teases in mammalian cells, is probably the best tool for prevention of unwanted proteolysis, for example during isolation of proteins from mammalian cells.

References

1. takada k (1995) mol. biol. rep. 21: 21–26 2. a. f. kisselev, a. l. goldberg. proteasome inhibitors: from research tools to drug candidates. chemistry & biology 8 (2001) 739-758. 3. w. matthews, j. driscoll, k. tanaka, a. ichihara, a.l. goldberg, involvement of the proteasome in various degradative processes in mammalian cells, proc. natl. acad. sci. usa 86 (1989) 2597-2601. 4. s. tsubuki, y. saito, m. tomioka, h. ito, s. kawashima, differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine, j. biochem. 119 (1996) 572-576. 5. d.h. lee, a.l. goldberg, selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in saccharomyces cerevisiae, j. biol. chem. 271 (1996) 27280-27284.

PROTEASOME INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

PROTEASOME INHIBITOR I Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Nextpeptide Inc	58
GIHI CHEMICALS CO.,LIMITED	58
Nanjing TGpeptide	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Amadis Chemical Company Limited	58

PROTEASOME INHIBITOR I Spectrum

PROTEASOME INHIBITOR I(158442-41-2)MS

158442-41-2(PROTEASOME INHIBITOR I)Related Search:

PROTEASOME INHIBITOR MG-132 PROTEASOME INHIBITOR MG-115 PROTEASOME INHIBITOR III,Cbz-Leu-Leu-Leu-B(OH)2, Proteasome Inhibitor III PROTEASOME INHIBITOR I PROTEASOME INHIBITOR II,PROTEASOME INHIBITOR II (ALDEHYDE)

PROTEASOME INHIBITOR IV 1 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) 1 MG PROTEASOME INHIBITOR PSI Z-ILE-GLU-(OTBU)-ALA-LEU-H (ALDEHYDE) 1 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE) PROTEASOME INHIBITOR PSI Z-ILE-GLU-(OTBU)-ALA-LEU-H (ALDEHYDE)

5 MG PROTEASOME INHIBITOR PSI Z-ILE-GLU-(OTBU)-ALA-LEU-H (ALDEHYDE) Proteasome Inhibitor Set 5 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE) PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) Proteasome Inhibitor Set II

PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE)

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CARBOBENZOXY-L-ISOLEUCYL-GAMMA-T-BUTYL-L-GLUTAMYL-L-ALANYL-L-LEUCINAL BENZYLOXYCARBONYL-L-ISOLEUCYL-[(2S)-2-AMINO-4-(T-BUTYLOXYCARBONYL)BUTANOYL]-L-ALANYL-L-LEUCINAL PROTEASOME INHIBITOR I PROTEASOME INHIBITOR I (ALDEHYDE) PROTEASOME INHIBITOR PSI PSI N-CBZ-ILE-GLU(O-T-BUTYL)-ALA-LEUCINAL Z-IE(OTBU)AL-CHO Z-ILE-GLU(OBUT)-ALA-LEU-H Z-ILE-GLU(OBUT)-ALA-LEU-H (ALDEHYDE) Z-ILE-GLU(OTBU)-ALA-LEU-ALDEHYDE Z-ILE-GLU(OTBU)-ALA-LEU-CHO z-ile-glu(o-t-butyl)-ala-leucinal Z-ILE-GLU(OTBU)-ALA-LEUCINAL N-carbobenzyloxy-Ile-Glu(O-tert-butyl)-Ala-leucinal M.W. 618.77 C32H50N4O8 arbobenzoxy-l-isoleucyl-gamma-t-butyl-l-glutamyl-l-alanyl-l-leucinal N-Cb L-AlaninaMide, N-[(phenylMethoxy)carbonyl]-L-isoleucyl-L-a-glutaMyl-N-[(1S)-1-forMyl-3 -Methylbutyl]-, 1,1-diMethylethyl ester ProteasoMe Inhibitor 1 PSI PROTEASOME INHIBITOR I N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide PROTEASOME INHIBITOR I ;Z-ILE-GLU(OTBU)-ALA-LEU-CHO CS-1340 L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester PROTEASOME INHIBITOR I USP/EP/BP Cbz-Ile-Glu(OtBu)-Ala-Leu-al CBZ-Ile-Glu(OtBu)-Ala-Leu-aldehyde N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide HBL6 cells,Inhibitor,apoptosis,PSI,Proteasome Inhibitor1,Proteasome Inhibitor 1,Primary effusion lymphoma (PEL),BC3 cells,KSHV,inhibit,Proteasome Inhibitor-1,NF-κB,Proteasome 158442-41-2 C32H50N4O8 Calpain and Proteasome Inhibitors Intracellular Protein Degradation Nitric Oxide and Cell Stress Caspases/Apoptosis Calpain and Proteasome Inhibitors Intracellular Protein Degradation Aldehydes Bioactive Small Molecules Building Blocks C13-C60 Carbonyl Compounds Cell Biology Cell Signaling and Neuroscience Chemical Synthesis Nitric Oxide and Cell Stress Organic Building Blocks Z Pepetides ProteasomeInhibitors peptides