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FK 888

FK 888 structure

CAS No.: 138449-07-7

Chemical Name:: FK 888

Synonyms: FK 888;FK888 hydrate;N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide;L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate

CBNumber:: CB8785831

Molecular Formula:: C36H36N4O4

Molecular Weight:: 588.7

MDL Number:: MFCD00274042

MOL File:: 138449-07-7.mol

Last updated:2023-06-30 15:45:59

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FK 888 Properties

Boiling point	901.9±65.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: ≥13mg/mL
form	powder
pka	13.01±0.40(Predicted)
color	white to tan
optical activity	[α]/D -135 to -145°, c = 1 in methanol

SAFETY

Risk and Safety Statements

WGK Germany	3

FK 888 price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	2400	FK888 ≥98%(HPLC)	138449-07-7	10	$304	2021-12-16	Buy
TRC	F370403	FK888	138449-07-7	25mg	$960	2021-12-16	Buy
ApexBio Technology	B5300	FK888	138449-07-7	10mg	$465	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0001359	FK 888 95.00%	138449-07-7	10MG	$799.21	2021-12-16	Buy

Product number	Packaging	Price	Buy
2400	10	$304	Buy
F370403	25mg	$960	Buy
B5300	10mg	$465	Buy
PEP0001359	10MG	$799.21	Buy

FK 888 Chemical Properties,Uses,Production

Uses

FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.

Definition

ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide.

Biological Activity

Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

storage

Store at -20°C

FK 888 Preparation Products And Raw materials

Raw materials

Preparation Products

FK 888 Suppliers

Global( 21)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4030	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
EMMX Biotechnology LLC	60
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
MedBioPharmaceutical Technology Inc	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58
ApexBio Technology	58

FK 888 Spectrum

FK 888(138449-07-7)MS FK 888(138449-07-7)IR1 FK 888(138449-07-7)IR2

138449-07-7(FK 888)Related Search:

3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE 2-NAPHTHALEN-2-YL-ETHYLAMINE (1-Methyl-1H-indol-3-yl)-methylamine 1H-PYRROLE-3-METHANAMINE, 1-METHYL- 1H-Indole-3-carboxamide(9CI)

FK 888 1-Methylindole-3-carboxaldehyde Gramine

1of2

N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate FK 888 L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate FK888 hydrate 138449-07-7