C12-200
- CAS No.
- 1220890-25-4
- Chemical Name:
- C12-200
- Synonyms
- C12-200;C-12-200,C12200,C12 200;1-[2-[Bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol;2-Dodecanol, 1,1'-[[2-[4-[2-[[2-[bis(2-hydroxydodecyl)amino]ethyl](2-hydroxydodecyl)amino]ethyl]-1-piperazinyl]ethyl]imino]bis-;1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
- CBNumber:
- CB88125233
- Molecular Formula:
- C70H145N5O5
- Molecular Weight:
- 1136.93
- MDL Number:
- MFCD32062847
- MOL File:
- 1220890-25-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| C12-200 ≥95% | 36699 | 10mg | $120 |
| C12-200 ≥95% | 36699 | 25mg | $240 |
| C12-200 ≥95% | 36699 | 50mg | $421 |
| C12-200 ≥95% | 36699 | 100mg | $780 |
| Boiling point | 1017.6±65.0 °C(Predicted) |
|---|---|
| Density | 0.948±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in Ethanol, DMSO, DMF |
| pka | 14.45±0.20(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| InChIKey | RVHYPUORVDKRTM-UHFFFAOYSA-N |
| SMILES | N(CC(O)CCCCCCCCCC)(CC(O)CCCCCCCCCC)CCN1CCN(CCN(CCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
C12-200 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36699 | C12-200 ≥95% | 1220890-25-4 | 10mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 36699 | C12-200 ≥95% | 1220890-25-4 | 25mg | $240 | 2026-04-30 | Buy |
| Cayman Chemical | 36699 | C12-200 ≥95% | 1220890-25-4 | 50mg | $421 | 2026-04-30 | Buy |
| Cayman Chemical | 36699 | C12-200 ≥95% | 1220890-25-4 | 100mg | $780 | 2026-04-30 | Buy |
C12-200 Chemical Properties,Uses,Production
Description
C12-200 is a branched-chain ionizable cationic lipidoid with five hydroxyl groups. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). The hydroxyl groups enables further derivatization or replacement with other reactive functional groups.
Uses
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B[1][2][3].
in vivo
C12-200 (0.25 or 0.5 mg/kg, i.v., single injection) delivers exogenous human mRNA, producing target proteins at supraphysiological levels. Human erythropoietin (EPO) and coagulation factor IX (FIX) demonstrate potent pharmacodynamic effects in the KO mouse model[2].
| Animal Model: | Hemophilia B (FIX knockout (KO)) mouse model[2] |
| Dosage: | 0.25 or 0.5 mg/kg |
| Administration: | Intravenous injection (i.v.), single injection |
| Result: | led to plasma FIX levels of 400 ng/ml and 1.77 μg/ml with doses of 0.25 and 0.50 mg/kg, respectively, in KO mice. And C12-200 resulted in a significant increase in activity in the treated mice. |
References
[1] Khare P, et al. Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells. AAPS J. 2021;24(1):8. Published 2021 Dec 6. DOI:10.1208/s12248-021-00653-2
[2] DeRosa F, et al. Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system. Gene Ther. 2016;23(10):699-707. DOI:10.1038/gt.2016.46
[3] Kauffman KJ, et al. Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs. Nano Lett. 2015 Nov 11;15(11):7300-6. DOI:10.1021/acs.nanolett.5b02497
C12-200 Preparation Products And Raw materials
Raw materials
Preparation Products
C12-200 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 | info@chuchangbiotech.com | China | 202 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +8618913958656 | inquiries@moldeep.com | China | 19983 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | 025-58393656 18913958656 | sales@hengbeichem.cn | China | 224 | 58 |
