Nicaraven
- CAS No.
- 79455-30-4
- Chemical Name:
- Nicaraven
- Synonyms
- AVS;NICARAVEN;Nicaraven, >98%;Nicaraven, 79455-30-4;Nicaraven, 10 mM in DMSO;1,2-bis(nicotinamido)propane;n,n'-propylenedinicotinamide;N,N'-Propylenebisnicotinamide;N,N'-Propylenebis(nicotinamide);N,N'-(Propane-1,2-diyl)dinicotinaMide
- CBNumber:
- CB8841557
- Molecular Formula:
- C15H16N4O2
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD00411904
- MOL File:
- 79455-30-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Nicaraven ≥98% | 23482 | 5mg | $32 |
| Nicaraven ≥98% | 23482 | 10mg | $57 |
| Nicaraven ≥98% | 23482 | 25mg | $116 |
| Nicaraven | FN65102 | 10mg | $62.5 |
| Nicaraven | FN65102 | 50mg | $81 |
| More product size | |||
| Melting point | 156-157° |
|---|---|
| Boiling point | 635.9±40.0 °C(Predicted) |
| Density | 1.213±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 2 mg/ml |
| form | A crystalline solid |
| pka | 12.93±0.46(Predicted) |
| color | White to off-white |
| FDA UNII | UD8PEV6JBD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Nicaraven price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23482 | Nicaraven ≥98% | 79455-30-4 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23482 | Nicaraven ≥98% | 79455-30-4 | 10mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 23482 | Nicaraven ≥98% | 79455-30-4 | 25mg | $116 | 2024-03-01 | Buy |
| Biosynth Carbosynth | FN65102 | Nicaraven | 79455-30-4 | 10mg | $62.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FN65102 | Nicaraven | 79455-30-4 | 50mg | $81 | 2021-12-16 | Buy |
Nicaraven Chemical Properties,Uses,Production
Description
Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.
Uses
Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger.
in vivo
Nicaraven inhibits lipid peroxidation in the liver, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver[1]. Nicaraven increases the number of c-kit(+) stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function is completely protected with nicaraven treatment[2]. Administration of nicaraven significantly increases the number, improves the colony-forming capacity, and decreases the DNA damage of hematopoietic stem/progenitor cells. The urinary levels of 8-oxo-2′-deoxyguanosine, a marker of DNA oxidation, are significantly lower in mice that are given nicaraven compared with those that receive a placebo. The administration of nicaraven significantly decreases the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma of mice[3].
References
[1] Komiya T, et al. A novel free radical scavenger, nicaraven, inhibits human platelet aggregation in vitro. Clin Neuropharmacol. 1999 Jan-Feb;22(1):11-4. DOI:10.1097/00002826-199901000-00003
[2] Yokota R, et al. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery. 2000 Jun;127(6):661-9. DOI:10.1067/msy.2000.105864
[3] Ali H, et al. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. DOI:10.1016/j.bbrc.2014.08.112
[4] Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. DOI:10.1371/journal.pone.0060023
Nicaraven Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5945 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
