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Meptazinol

Meptazinol
Meptazinol structure
CAS No.
54340-58-8
Chemical Name:
Meptazinol
Synonyms
MeptaMizol;MEPTAZINOL;Meptazinol A;Meptazinol-13C-d3;Meptazinol USP/EP/BP;MEPTAZINOL 54340-58-8;3-(3-ethyl-1-Methylazepan-3-yl)phenol;3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol;3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol;Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-
CBNumber:
CB8841562
Molecular Formula:
C15H23NO
Formula Weight:
233.35
MOL File:
54340-58-8.mol

Meptazinol Properties

Melting point:
127-133°C
Boiling point:
354.8±35.0 °C(Predicted)
Density 
0.997
pka
9.95±0.10(Predicted)
FDA UNII
18Y7S5JKZD
ATC code
N02AX05

Meptazinol Chemical Properties,Uses,Production

Originator

Meptid,Wyeth,UK,1983

Uses

Analgesic.

Manufacturing Process

2-(m-Methoxyphenyl)butyronitrile in dry ether was added to a stirred suspension of sodium amide in liquid ammonia. The mixture was stirred for 30 minutes then ethyl-4-iodobutyrate (99.25 g, 0.4 mol) in dry ether (200 ml) was added dropwise. The mixture was stirred at the temperature of refluxing liquid ammonia for 5 hours. Ammonium chloride (10 g) was added and the mixture allowed to warm to room temperature. Water (300 ml) was added, the organic layer separated, washed with water, 2 N sulfuric acid and water. After drying over magnesium sulfate and removing the ether, the product was distilled yielding ethyl 5-cyano-5-(mmethoxyphenyl)heptanoate.
That material was hydrogenated in cyclohexane using a Raney nickel catalyst. The product after distillation was recrystallized from ethyl acetate affording 10.0 g of 6-ethyl-(m-methoxyphenyl)hexahydro-2H-azepin-2one, MP 87°C to 88°C.
The azepinone (9.1 g) in dry tetrahydrofuran (50 ml) and ether (50 ml) was added dropwise to a stirred suspension of aluminum lithium hydride (7.5 g) in dry ether (50 ml). After heating under reflux for 3 hours the reaction mixture was worked up and distilled yielding 7.66 g of a compound which was a colorless oil, BP 108°C to 110°C/0.01 mm.
That product was then heated under reflux with 50% hydrobromic acid for 1.5 hours. The reaction mixture was evaporated to dryness and reevaporated with three portions of propan-2-ol. The oil obtained was dissolved in propan-2-ol and diluted with ether. 3-Ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine was obtained. That material in turn was reductively methylated by hydrogenation in the presence of formaldehyde in absolute ethanol solution to give 3-ethyl-3-(m-methoxyphenyl)-1-methylhexahydro-1H-azepine.
The methoxy group was converted to a hydroxy group by refluxing with 80% HBr giving meptazinol hydrobromide.

Therapeutic Function

Analgesic

Meptazinol Preparation Products And Raw materials

Raw materials

Preparation Products


Meptazinol Suppliers

Global( 53)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17505 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58

View Lastest Price from Meptazinol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Meptazinol
54340-58-8
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-11 Meptazinol USP/EP/BP
54340-58-8
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2019-07-06 Meptazinol
54340-58-8
US $2.00 / kg 1kg 99% 100kg career henan chemical co

54340-58-8(Meptazinol)Related Search:


  • MEPTAZINOL
  • 3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol
  • 3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol
  • (+/-)-3-(3-ethyl-1-Methylhexahydro-1H-azepin-3-yl)phenol
  • Meptazinol A
  • 3-(3-ethyl-1-Methylazepan-3-yl)phenol
  • MeptaMizol
  • Meptazinol-13C-d3
  • Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-
  • Meptazinol USP/EP/BP
  • MEPTAZINOL 54340-58-8
  • 54340-58-8
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