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FALECALCITRIOL

FALECALCITRIOL Structure
FALECALCITRIOL structure
CAS No.
83805-11-2
Chemical Name:
FALECALCITRIOL
Synonyms
Hornel;ST 630;Fulstan;Ro 23-4194;Flocalcitrol;Flocacitriol;Falecalcitol;Flocalcitriol;F6-1,25(OH)2D3;FALECALCITRIOL
CBNumber:
CB8849801
Molecular Formula:
C27H38F6O3
Molecular Weight:
524.58
MDL Number:
MFCD00870595
MOL File:
83805-11-2.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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FALECALCITRIOL Properties

Boiling point 576.9±50.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Store at -20°C,unstable in solution, ready to use.
solubility Soluble in DMSO
form Powder
pka 9.77±0.29(Predicted)
FDA UNII G70A8514T8

FALECALCITRIOL price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC F101110 Falecalcitriol 83805-11-2 10mg $11000 2021-12-16 Buy
American Custom Chemicals Corporation API0002674 FALECALCITRIOL 95.00% 83805-11-2 10MG $12127.5 2021-12-16 Buy
ChemScene CS-0801 Falecalcitriol 95.09% 83805-11-2 1mg $1056 2021-12-16 Buy
American Custom Chemicals Corporation API0002674 FALECALCITRIOL 95.00% 83805-11-2 1MG $1424.85 2021-12-16 Buy
Medical Isotopes, Inc. 17932 Falecalcitriol 83805-11-2 1mg $1790 2021-12-16 Buy
Product number Packaging Price Buy
F101110 10mg $11000 Buy
API0002674 10MG $12127.5 Buy
CS-0801 1mg $1056 Buy
API0002674 1MG $1424.85 Buy
17932 1mg $1790 Buy

FALECALCITRIOL Chemical Properties,Uses,Production

Description

Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.

Originator

University of Wisconsin (US)

Uses

Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.

brand name

Hornel, Fulstan

Hazard

A poison by ingestion.

FALECALCITRIOL Preparation Products And Raw materials

Raw materials

Preparation Products

FALECALCITRIOL Suppliers

Global( 87)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 sales@dolonchem.com CHINA 2972 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4022 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
ChemExpress 		+86-021-58950125 info@chemexpress.com China 557 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Nanjing Dolon Biotechnology Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
CR Corporation Lomited 		58
ChemExpress 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from FALECALCITRIOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FALECALCITRIOL pictures 2020-02-19 FALECALCITRIOL
83805-11-2
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

83805-11-2(FALECALCITRIOL)Related Search:

5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester methylene calcitriol INECALCITOL Calcitriol (S)-(-)-1,1,1-TRIFLUOROOCTAN-2-OL
FALECALCITRIOL VitaMin D4 CALCIFEDIOL Calcifediol Monohydrate (S)-(-)-1,1,1-TRIFLUOROHEPTAN-2-OL
1,2-DIMETHYLENE-CYCLOHEXANE (S)-(-)-1,1,1-TRIFLUORODECAN-2-OL (R)-(+)-1 1 1-TRIFLUOROOCTAN-2-OL 97 (S)-(-)-1,1,1-TRIFLUORODODECAN-2-OL 1,1,1-TRIFLUORO-2-OCTANOL
(S)-(-)-1,1,1-TRIFLUORONONAN-2-OL (S)-(-)-1,1,1-TRIFLUOROUNDECAN-2-OL (R)-(+)-1-FLUORO-2-OCTANOL

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(+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)- Flocalcitriol Flocalcitrol Fulstan Ro 23-4194 ST 630 26,27-F6-1,25-(OH)2D3 F6-1,25(OH)2D3 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol 26,27-Hexafluoro-1α,25-dihydroxyvitamine D3 FALECALCITRIOL (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol (1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-Methyl-5-(trifluoroMethyl)hexyl]octahydro-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol (1α,3β,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol F6-1α,25-DihydroxyvitaMin D3 Flocacitriol 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)- Falecalcitol Hornel 83805-11-2 C27H38F6O3 Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals