ChemicalBook >> CAS DataBase List >>L371,257

L371,257

CAS No.
162042-44-6
Chemical Name:
L371,257
Synonyms
257;L-371;L371,257;L371,257,L 371,257;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-
CBNumber:
CB8850593
Molecular Formula:
C28H33N3O6
Molecular Weight:
507.58
MDL Number:
MFCD00944944
MOL File:
162042-44-6.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

L371,257 Properties

Boiling point 728.9±60.0 °C(Predicted)
Density 1.282±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 10 mM in DMSO with gentle warming
form Powder
pka 0.73±0.20(Predicted)
color White to off-white
FDA UNII 98KJ8P9APP
UNSPSC Code 12352200
NACRES NA.77

L371,257 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3899 L-371,257 ≥98% (HPLC) 162042-44-6 10mg $179 2025-07-31 Buy
Sigma-Aldrich SML3899 L-371,257 ≥98% (HPLC) 162042-44-6 50mg $3200 2025-07-31 Buy
Tocris 2410 L-371,257 ≥99%(HPLC) 162042-44-6 10 $269 2021-12-16 Buy
Usbiological 255632 L-371,257 162042-44-6 10mg $516 2021-12-16 Buy
TRC L352940 L-371,257 162042-44-6 1mg $160 2021-12-16 Buy
Product number Packaging Price Buy
SML3899 10mg $179 Buy
SML3899 50mg $3200 Buy
2410 10 $269 Buy
255632 10mg $516 Buy
L352940 1mg $160 Buy

L371,257 Chemical Properties,Uses,Production

Uses

L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.

Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

in vivo

Systemic administration of nonpenetrant oxytocin receptor antagonist L-371,257 (0.5 and 1.0 mg/kg; i.p. injection) stimulates weight gain in rats[3].

Animal Model:Six-hour fasted rats[3]
Dosage:0.5 and 1.0 mg/kg
Administration:Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days.
Result:A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment.
When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g).

storage

Store at RT

L371,257 Preparation Products And Raw materials

Raw materials

Preparation Products

L371,257 Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
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Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 3193328036@qq.com China 29763 68
Hebei Weite Medical Technology Co., Ltd 13180081292 contact@wetogethermed.com China 7994 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 3210 58

L371,257 Spectrum

L371,257 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one 2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro- 257 L-371 L371,257,L 371,257 162042-44-6 C28H33N3O6