L371,257
- CAS No.
- 162042-44-6
- Chemical Name:
- L371,257
- Synonyms
- 257;L-371;L371,257;L371,257,L 371,257;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-
- CBNumber:
- CB8850593
- Molecular Formula:
- C28H33N3O6
- Molecular Weight:
- 507.58
- MDL Number:
- MFCD00944944
- MOL File:
- 162042-44-6.mol
- MSDS File:
- SDS
| Boiling point | 728.9±60.0 °C(Predicted) |
|---|---|
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 10 mM in DMSO with gentle warming |
| form | Powder |
| pka | 0.73±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | 98KJ8P9APP |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
L371,257 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3899 | L-371,257 ≥98% (HPLC) | 162042-44-6 | 10mg | $179 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML3899 | L-371,257 ≥98% (HPLC) | 162042-44-6 | 50mg | $3200 | 2025-07-31 | Buy |
| Tocris | 2410 | L-371,257 ≥99%(HPLC) | 162042-44-6 | 10 | $269 | 2021-12-16 | Buy |
| Usbiological | 255632 | L-371,257 | 162042-44-6 | 10mg | $516 | 2021-12-16 | Buy |
| TRC | L352940 | L-371,257 | 162042-44-6 | 1mg | $160 | 2021-12-16 | Buy |
L371,257 Chemical Properties,Uses,Production
Uses
L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.
Biological Activity
Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.
in vivo
Systemic administration of nonpenetrant oxytocin receptor antagonist L-371,257 (0.5 and 1.0 mg/kg; i.p. injection) stimulates weight gain in rats[3].
| Animal Model: | Six-hour fasted rats[3] |
| Dosage: | 0.5 and 1.0 mg/kg |
| Administration: | Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days. |
| Result: | A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment. When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g). |
storage
Store at RT
L371,257 Preparation Products And Raw materials
Raw materials
Preparation Products
L371,257 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| Hebei Weite Medical Technology Co., Ltd | 13180081292 | contact@wetogethermed.com | China | 7990 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3210 | 58 |
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