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Diethyl malonate

Description References
Diethyl malonate
Diethyl malonate structure
CAS No.
105-53-3
Chemical Name:
Diethyl malonate
Synonyms
DEM;FEMA 2375;MALONIC ESTER;ETHYL MALONATE;Diethyl malonat;DIETHYL MALONATE;Diethyi malonate;AKOS BBS-00004262;DICARBETHOXYMETHANE;Ethyl propanedioate
CBNumber:
CB8852658
Molecular Formula:
C7H12O4
Formula Weight:
160.17
MOL File:
105-53-3.mol

Diethyl malonate Properties

Melting point:
-50 °C
Boiling point:
199 °C(lit.)
Density 
1.055 g/mL at 25 °C(lit.)
vapor density 
5.52 (vs air)
vapor pressure 
1 mm Hg ( 40 °C)
refractive index 
n20/D 1.413(lit.)
FEMA 
2375 | DIETHYL MALONATE
Flash point:
212 °F
storage temp. 
Store below +30°C.
solubility 
20.8g/l (External MSDS)
pka
13.5(at 25℃)
form 
Liquid
explosive limit
0.8-12.8%(V)
Water Solubility 
Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water.
Merck 
14,3823
JECFA Number
614
BRN 
774687
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents,
InChIKey
IYXGSMUGOJNHAZ-UHFFFAOYSA-N
CAS DataBase Reference
105-53-3(CAS DataBase Reference)
NIST Chemistry Reference
Propanedioic acid, diethyl ester(105-53-3)
EPA Substance Registry System
Propanedioic acid, diethyl ester(105-53-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xi
Risk Statements  36/37/38-36
Safety Statements  24/25-26
WGK Germany  1
RTECS  OO0700000
Autoignition Temperature 435 °C DIN 51794
Hazard Note  Irritant
TSCA  Yes
HS Code  29171910
Toxicity LD50 orally in Rabbit: 15720 mg/kg LD50 dermal Rabbit > 16000 mg/kg
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
Precautionary statements:
P403+P235 Store in a well-ventilated place. Keep cool.

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Diethyl malonate price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 04151 Diethyl malonate analytical standard 105-53-3 1ml $50.7 2018-11-13 Buy
Sigma-Aldrich 04151 Diethyl malonate analytical standard 105-53-3 5ml $201 2018-11-13 Buy
TCI Chemical M0029 Diethyl Malonate >99.0%(GC) 105-53-3 25mL $14 2018-11-22 Buy
TCI Chemical M0029 Diethyl Malonate >99.0%(GC) 105-53-3 500mL $25 2018-11-22 Buy
Alfa Aesar A15468 Diethyl malonate, 99% 105-53-3 500g $29.5 2018-11-13 Buy

Diethyl malonate Chemical Properties,Uses,Production

Description

As an organic compound, diethyl malonate belongs to the diethyl ester of malonic acid, which is present naturally in guava fruits, melons, grapes, pineapples, blackberries and strawberries as a colorless liquid with an apple-like odor. It is a flavor ingredient commonly found in perfumes, artificial flavorings, alcoholic beverages, various wines and spirits due to its natural pleasant odor. It is also used as an essential intermediate in the syntheses of numerous pharmaceuticals, such as barbiturates, vitamins B1 and B6, non-steroidal anti-inflammatory agents. Besides, diethyl malonate is also involved in organic synthesis of other compounds, such as alpha-aryl malonates, mono-substituted and di-substituted acetic acid. And it can react with benzaldehyde for the production of diethyl benzylidenemalonate in Knoevenagel condensation reaction.

References

https://en.wikipedia.org/wiki/Diethyl_malonate
https://pubchem.ncbi.nlm.nih.gov/compound/7761#section=Safety-and-Hazards
https://www.alfa.com/zh-cn/catalog/A15468/
http://www.hmdb.ca/metabolites/HMDB29573
http://www.chemicalland21.com/industrialchem/organic/DIETHYL%20MALONATE.htm

Chemical Properties

colourless liquid

Uses

Diethyl Malonate occurs naturally in grapes and strawberries. It is used in the preparation of barbiturates, artificial flavourings, vitamin B1, and vitamin B6 as well as in perfumes.

Uses

manufacture of barbiturates.

Safety Profile

Mildly toxic by ingestion. A skin irritant. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use water to blanket fire, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

If too impure (IR, NMR) the ester (250g) is heated on a steam bath for 36hours with absolute EtOH (125mL) and conc H2SO4 (75mL), then fractionally distilled under reduced pressure. Otherwise fractionally distil it under reduced pressure and collect the steady boiling middle fraction. [Beilstein 2 IV 1881.]

Diethyl malonate Preparation Products And Raw materials

Raw materials

Preparation Products


Diethyl malonate Suppliers

Global( 361)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1747 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19947 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1373 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32606 55
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025-83697070;product@chemlin.com.cn
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Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
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86-21-51086038
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View Lastest Price from Diethyl malonate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Diethyl malonate
105-53-3
US $1.00 / kg 1kg 99% 100KG career henan chemical co

Diethyl malonate Spectrum


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