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N-Methyl-4-piperidinol

N-Methyl-4-piperidinol structure

CAS No.: 106-52-5

Chemical Name:: N-Methyl-4-piperidinol

Synonyms: 1-methylpiperidin-4-ol;1-METHYL-4-PIPERIDINOL;4-Piperidinol, 1-methyl-;H431;NM4PPOL;-4-piperidinoL;N-Methylpiperidol;N-Methyl-4-hydroxy;TIMTEC-BB SBB004301;1-methyl-4-piperidino

CBNumber:: CB8852683

Molecular Formula:: C6H13NO

Molecular Weight:: 115.17

MDL Number:: MFCD00006500

MOL File:: 106-52-5.mol

MSDS File:: SDS

Last updated:2023-09-21 15:25:22

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N-Methyl-4-piperidinol Properties

Melting point	29-31 °C(lit.)
Boiling point	200 °C(lit.)
Density	0.98 g/mL at 20 °C(lit.)
vapor pressure	8.13-11Pa at 25℃
refractive index	n20/D 1.479
Flash point	190 °F
storage temp.	2-8°C
form	Liquid After Melting
pka	14.87±0.20(Predicted)
color	Clear colorless to brown
Viscosity	44.361mm2/s
Water Solubility	MISCIBLE
Sensitive	Hygroscopic
BRN	103024
LogP	-0.14-0.756 at 25℃
CAS DataBase Reference	106-52-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Hydroxy-N-methylpiperidine(106-52-5)
EPA Substance Registry System	4-Piperidinol, 1-methyl- (106-52-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H315-H318-H335

Precautionary statements

P280-P302+P352-P305+P351+P338+P310

Hazard Codes

Xi,C

Risk Statements

37/38-41-36/37/38-34

Safety Statements

26-37/39-45-36/37/39-27

WGK Germany

Hazard Note

Irritant

TSCA

Yes

HS Code

29333999

NFPA 704

	2
2		0

N-Methyl-4-piperidinol price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H42206	N-Methyl-4-piperidinol 98%	106-52-5	100g	$89.5	2024-03-01	Buy
TCI Chemical	M0933	4-Hydroxy-1-methylpiperidine >98.0%(GC)(T)	106-52-5	25g	$28	2024-03-01	Buy
TCI Chemical	M0933	4-Hydroxy-1-methylpiperidine >98.0%(GC)(T)	106-52-5	500g	$223	2024-03-01	Buy
Alfa Aesar	L06415	4-Hydroxy-1-methylpiperidine, 98%	106-52-5	100g	$44.65	2024-03-01	Buy
Alfa Aesar	L06415	4-Hydroxy-1-methylpiperidine, 98%	106-52-5	500g	$149.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
H42206	100g	$89.5	Buy
M0933	25g	$28	Buy
M0933	500g	$223	Buy
L06415	100g	$44.65	Buy
L06415	500g	$149.65	Buy

N-Methyl-4-piperidinol Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6

Flammability and Explosibility

Not classified

N-Methyl-4-piperidinol synthesis

Synthesis of N-Methyl-4-piperidinol from 4-Hydroxypiperidine and Formaldehyde

N-Methyl-4-piperidinol Preparation Products And Raw materials

Raw materials

1-Methyl-4-piperidone 1-methyl-4-phenylpiperidin-4-ol N,N-DI-(BETA-CARBOETHOXYETHYL)METHYLAMINE 1-Methyl-4(1H)-pyridinone 1-Methyl-4-oxopiperidin-3-carboxylic acid ethyl ester

N-(1-METHYLPIPERIDIN-4-YL)ANILINE 3-HYDROXYGLUTARONITRILE 1-Methyl-4-piperidinol hydrochloride Aniline 4-Hydroxypiperidine

Formaldehyde N-Methyl-2-pyrrolidone Benzene

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Preparation Products

4-(1-METHYLPIPERIDIN-4-YLOXY)-3,5-DICHLOROBENZENAMINE 2-chloro-6-(1-methylpiperidin-4-yloxy)pyridin-4-amine 1-methylpiperidin-4-yl 4-iodobenzoate 4-Iodo-1-Methyl-piperidine 6-[(1-methylpiperidin-4-yl)oxy]pyridin-3-amine

N-Methyl-4-piperidinol Suppliers

Global( 396)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Siyang Liaoning Biochemical Products Co. Ltd	+86-15221114306; +8615221114306	2594582574@qq.com	China	574	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	alice@jndxj.com	China	309	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58

Supplier	Advantage
Siyang Liaoning Biochemical Products Co. Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Anhui Dexinjia Biopharm Co., Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from N-Methyl-4-piperidinol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	1-Methyl-4-Hydroxypiperidine 106-52-5	US $100.00-2000.00 / KG	1KG	98%	5MT per Month	Anhui Dexinjia Biopharm Co., Ltd
2023-09-21	1-Methyl-4-piperidinol 106-52-5	US $30.00 / kg	1kg	99%	1000t/year	Anhui Ruihan Technology Co., Ltd
2022-08-13	N-Methyl-4-piperidinol 106-52-5	US $110.00 / kg	1kg	99%	100 tons	Hebei Duling International Trade Co. LTD

1-Methyl-4-Hydroxypiperidine
106-52-5
US $100.00-2000.00 / KG
98%
Anhui Dexinjia Biopharm Co., Ltd

1-Methyl-4-piperidinol
106-52-5
US $30.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

N-Methyl-4-piperidinol
106-52-5
US $110.00 / kg
99%
Hebei Duling International Trade Co. LTD

N-Methyl-4-piperidinol Spectrum

N-Methyl-4-piperidinol(106-52-5)MS N-Methyl-4-piperidinol(106-52-5)¹HNMR N-Methyl-4-piperidinol(106-52-5)¹³CNMR N-Methyl-4-piperidinol(106-52-5)IR1 N-Methyl-4-piperidinol(106-52-5)Raman

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1-methyl-4-piperidino 1-Methylpiperidinol-(4) N-Methylpiperidol 4-HYDROXY-1-METHYLPIPERIDINE 4-HYDROXY-N-METHYLPIPERIDINE N-METHYL-4-HYDROXY PIPERIDINE NM4PPOL N-METHYL-4-PIPERIDINOL 1-HYDROXY-4-METHYLPIPERIDINE 1-METHYL-4-PIPERIDINOL HCL 1-METHYL-4-PIPERIDINOLHYDROCHOLORIDE 1-METHYL-4-HYDROXYPIPERIDINE TIMTEC-BB SBB004301 N-Methyl-4-hydroxy 4-Hydroxy-1-methylpiperidine 98% 1-Methyl-4-piperidinol, 4-Hydroxy-1-methylpiperidine 4-Hydroxy-l-methylpiperidine N-METIL-4-IDROSSIPIPERIDINA 4-Hydroxy-N-Methylpiperidine, 98% 100GR H431 1- Methyl-4- piperidinealcohol N-Methyl-4-piperidinol, 98%+ 4-Hydroxy-1-methylpiperidine,98% N-Methyl-4-piperidinol 98% 1-methyl-4-piperidin-1-iumol Pimavanserin Impurity 12 4-Hydroxy-1-methylpiperidine> -4-piperidinoL 4-Hydro xy-Ninethylp iperidine Loratadine Impurity 40 N-Methyl-4-hydroxy-piperidine (NMHP) 106-52-5 N-Methyl-4-piperidinol 4-Piperidinol, 1-methyl- 1-METHYL-4-PIPERIDINOL 1-methylpiperidin-4-ol 106-52-5 102-52-5 Building Blocks Heterocyclic Building Blocks Piperidines Building Blocks C5 to C7 Chemical Synthesis Heterocyclic Building Blocks Piperidines PHARMACEUTICAL INTERMEDIATES Piperidine