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N,N-Dimethylacetamide

Outline Chemical Properties Incompatibility Penetration pathways First aid Protective measures Medical Care Test methods Storage Transport requirements Application Production method Category Toxicity grading Acute toxicity Stimulus data Explosive hazardous characteristics Flammability hazard characteristics Extinguishing agent Occupational standards
N,N-Dimethylacetamide
N,N-Dimethylacetamide
CAS No.
127-19-5
Chemical Name:
N,N-Dimethylacetamide
Synonyms
DMAC;U-5954;nsc3138;SK 7176;NSC 3138;OmniPure?;CBC 510337;Hallucinogen;CH3CON(CH3)2;Acetic acid-di
CBNumber:
CB8853004
Molecular Formula:
C4H9NO
Formula Weight:
87.12
MOL File:
127-19-5.mol

N,N-Dimethylacetamide Properties

Melting point:
-20 °C
Boiling point:
164.5-166 °C(lit.)
Density 
0.937 g/mL at 25 °C(lit.)
vapor density 
3.89 (vs air)
vapor pressure 
40 mm Hg ( 19.4 °C)
refractive index 
n20/D 1.439(lit.)
Flash point:
158 °F
storage temp. 
0-6°C
solubility 
>1000g/l soluble
form 
Liquid
color 
Colorless to yellowish
PH
4 (200g/l, H2O, 20℃)
Relative polarity
6.3
explosive limit
1.7-11.5%(V)
Water Solubility 
miscible
λmax
λ: 270 nm Amax: 1.00
λ: 280 nm Amax: 0.30
λ: 290 nm Amax: 0.15
λ: 310 nm Amax: 0.05
λ: 320 nm Amax: 0.03
λ: 360-400 nm Amax: 0.01
Merck 
14,3227
BRN 
1737614
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
FXHOOIRPVKKKFG-UHFFFAOYSA-N
CAS DataBase Reference
127-19-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N,N-dimethyl-(127-19-5)
EPA Substance Registry System
Acetamide, N,N-dimethyl-(127-19-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xn,T
Risk Statements  11-20/22-61-20/21-36
Safety Statements  16-24-53-45-36-28-26
RIDADR  UN 1279 3/PG 2
WGK Germany  3
RTECS  TX9625000
3-10
Autoignition Temperature 914 °F
TSCA  Yes
HS Code  29241900
Hazardous Substances Data 127-19-5(Hazardous Substances Data)
Toxicity LD50 orally in rats: 5.4 ml/kg (Bartsch)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

N,N-Dimethylacetamide price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 154806 N,N-Dimethylacetamide spectrophotometric grade, ≥99% 127-19-5 1l $134 2018-11-20 Buy
Sigma-Aldrich 154806 N,N-Dimethylacetamide spectrophotometric grade, ≥99% 127-19-5 2l $189 2018-11-20 Buy
TCI Chemical D0641 N,N-Dimethylacetamide >99.0%(GC) 127-19-5 25mL $17 2018-11-22 Buy
TCI Chemical D0641 N,N-Dimethylacetamide >99.0%(GC) 127-19-5 500mL $29 2018-11-22 Buy
Alfa Aesar 022916 N,N-Dimethylacetamide, HPLC Grade, 99.5+% 127-19-5 1L $67.6 2018-11-16 Buy

N,N-Dimethylacetamide Chemical Properties,Uses,Production

Outline

N,N-dimethylacetamide dimethyl amine, also known as an acetyl group, an acetyl dimethylamine, referred to as the DMAC, which is a highly polar aprotic solvent, micro ammonia odor, very strong dissolving power, soluble wide, miscible with water, aromatics, esters, ketones, alcohols, ether, benzene and chloroform and other arbitrary and enable activation of molecular compounds. It is widely used as a solvent and a catalyst. The solvent, with high boiling point, flash point, thermal stability and chemical stability of the solvent, is used for polyacrylonitrile spinning solvent, synthetic resin and natural resins, formic acid vinyl ester resin, vinyl pyridine copolymer and aromatic carboxylic acid. The catalyst can be used in the process of urea heating to produce the reaction of cyanide, sodium halide and metal cyanide to produce the reaction of alkyl acetylene, organic halide and isocyanate. N,N-dimethylacetamide also can be used as electrolytic solvent and photography with coupler solvent, de paint agent, organic synthesis of raw materials, pesticide and pharmaceutical raw materials. Separation of styrene from C8 fraction, extraction, distillation, solvent, etc..
Invasive dangerous situation
Inhaled toxic (toxicity stronger than dimethylformamide), decomposition products may be absorbed through the skin, eye, skin and mucous membranes, which have a strong irritant. See "dimethylformamide." Combustible. Rat oral LD505.4ml/kg. The allowable concentration in air is US 10ppm (35mg/m3).

Chemical Properties

Transparent colorless liquid. The organic solvent can be mixed with any water, alcohol, ether, ester, benzene, chloroform, and aromatic compounds.

Incompatibility

The N, N-Dimethylacetamide are incompatible wiyb carbon tetrachloride and other halogenated compounds. Unsaturated aliphatic compounds are soluble in this product, but saturated aliphatic solubility of the compound in this product is small. The solubility of hydrolysis product is small. But in the presence of acid, it can accelerate the hydrolysis. This product has good stability, and it does not decompose during distillation. With a strong base to form acetates and alkyl amines, in the presence of a proton, the alcohol can have solution when heated.

Penetration pathways

Steam inhalation, skin absorption, ingestion, contact with the eyes and skin.
The workers, who are often exposed to dimethyl acetamide, observed jaundice, liver damage, but in general it can be quickly restored. When someone with FDA uses it as anticancer drugs and large doses of oral symptoms, it can cause depression, lethargy, visual hallucinations. It may also occur heart, kidney and brain degeneration. DMA mouse embryo has toxic effects on the rabbit have teratogenic effects.

First aid

If such chemicals like splashed into the eyes, you should rinse with running water 15min immediately; if contact with skin, you should wash it immediately with plenty of water; if they are swallowed, you should be given medical attention, clothing with plenty of water, induce vomiting, gastric lavage. Do not induce vomiting with unconscious person. Instead, they should be sent to the hospital at once.

Protective measures

Workshop should be ventilated, confined to production equipment. At high vapor concentrations work place, you should use an organic vapor respirator or air supplied respirator, gloves and protective clothing to prevent absorption through the skin. Wear goggles to prevent splashing into the eyes. In the workplace with splashing or spills of this substance, you should be taken off the wet clothes immediately and thoroughly wash the contaminated surface of the skin. Distribute to workers clean clothes before going to work every day, and take a shower after work.

Medical Care

When the pre-employment and periodic medical examinations, we should pay special attention to the skin, the central nervous system, liver disease or liver function tests.

Test methods

Measured in the air: adsorption with silica, methanol and analyzed by gas chromatography.

Storage

Storage with iron costumes to prevent the mechanical damage. Store in a cool, dry place, avoid light exposure, away from any possible source of ignition.

Transport requirements

N,N-dimethylacetamide Department are toxic flammable liquids, adjustment shall be toxic substances provides storage and transportation. Transportation shall be marked "dangerous drugs" mark, and prevent the sun, impact, when handling, attention gently on the container.
Recommended methods of controlling waste incineration (incinerators shall have a scrubber or thermal means to reduce the discharge of NOx).

Application

Production method

1. Acetic anhydride method dimethylamine and acetic anhydride have acylation reaction at 0-20 ℃, and then neutralized with low temperature liquid removing acetic, isolated from sodium acetate and Neutralization Solution and alkali washing, distillation, boiling range 164-166.5 DEG C fraction for the finished product. Material consumption fixed: acetic anhydride (95%) 1150kg/t, dimethylamine (40%) 1898kg/t.
2. Acetyl chloride method, by the reaction of dimethylamine and chloride, can also be prepared in dimethylacetamide. Compared with the process of the current domestic acetic anhydride process, it can reduce production costs, and improve economic efficiency.
3. Acetic acid method Fushun Research Institute of Chemical equipment using acetic acid and dimethylamine synthesis, and achieved good results. The process is characterized by the use of advanced catalytic distillation technology, strengthen reaction, reduce energy consumption, separation and product yield greatly improved, simplified the process. Compared to the synthesis process of this technology and two methylacetamide acetic anhydride methods, it can reduce production costs, improve economic benefits. China is currently more of people use it.
4. Study abroad Oxo trimethylamine and carbon monoxide carbonylation synthesis to produce N,N-dimethylacetamide approach. The reaction with iron, cobalt, nickel iodide or bromide as a catalyst.

Category

Flammable liquids

Toxicity grading

Poisoning

Acute toxicity

Oral-rat LD50: 4300 mg/kg; Oral-Mouse LD50: 4620 mg/kg

Stimulus data

Skin-Rabbit 10 mg/24 hr mild; Eye-rabbit mild 100 mg

Explosive hazardous characteristics

Mixed with air can be explosive

Flammability hazard characteristics

In case of fire, high temperature, strong oxidants combustible; combustion emissions of toxic nitrogen oxide fumes.

Extinguishing agent

Foam, powder, carbon dioxide

Occupational standards

TLV-TWA 10 PPM (35 mg/cubic meter); STEL 15 PPM (50 mg/m3)

Chemical Properties

Dimethylacetamide occurs as a clear, colorless, slightly hygroscopic liquid. It has a weak ammonia-like or fish-like odor.

Chemical Properties

colourless liquid with a faint ammonia odour

Definition

ChEBI: A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.

Uses

Solvent for many organic reactions and in industrial applications.

Production Methods

Dimethylacetamide has been produced by the reaction of acetic acid with dimethylamine (Siegle, 1980).

Production Methods

Dimethylacetamide is manufactured from acetic acid and dimethylamine in a closed system.

General Description

A clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145°F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin.

Air & Water Reactions

Water soluble.

Reactivity Profile

N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.

Health Hazard

Liquid causes mild irritation of eyes and skin. Ingestion causes depression, lethargy, confusion and disorientation, visual and auditory hallucinations, perceptual distortions, delusions, emotional detachment, and affective blunting.

Health Hazard

A study of 41 workers who had been exposed to dimethylacetamide from 2 to 10 years revealed the occurrence of disorders reflecting liver damage (Corsi, 1971). Retention of bromosulfophthalein was increased in 9 of 10 workers who had been exposed to dimethylacetamide for 7 to 10 years, and in 10 of 20 workers who had been exposed to dimethylacetamide for 2 to 7 years. Other parameters of hepatic function which were altered in the exposed individuals include proteinemia, cholesterolemia, activities of hepatic transaminases and alkaline phosphatase in serum, and bilirubinemia. Hepatomegaly was diagnosed in 14 workers.
In a clinical trial, dimethylacetamide was administered to patients with advanced malignancies and caused abnormal mental states (Weiss et al 1962a, b). This effect was observed at a dose of 400 mg/kg given daily for 3 or more days.
The symptoms were not seen at 300 mg/kg or lower. The second or third dose caused depression, lethargy, occasional confusion or disorientation. The fourth or fifth dose produced striking hallucinations, perceptual distortions and delusions in all nine patients. All patients reverted to normal several days after discontinuation of treatment with dimethylacetamide.

Fire Hazard

N,N-Dimethylacetamide is combustible.

Pharmaceutical Applications

Dimethylacetamide is used as a solvent in oral and injectable pharmaceutical formulations. It has been used as a cosolvent to solubilize poorly soluble drugs. The use of dimethylacetamide has also been investigated as a vehicle for the parenteral delivery of relatively small peptides.
The use of solvents such as dimethylacetamide has been shown to influence the size and rate of release of norfloxacin from nanoparticles.
Dimethylacetamide has also been used in topical formulations and has been evaluated as a permeation enhancer for transdermal drug delivery.

Industrial uses

Dimethylacetamide is a powerful industrial solvent, the uses of which are very similar to those of dimethylformamide (Siegle, 1980). Its strong solvent action renders it particularly useful in the manufacture of films and fibers and as a solvent for polyacrylonitrile, polyvinyl chloride, polyamides, cellulose derivatives and polystyrenes and in coatings and adhesive formulations. Dimethylacetamide dissolves many inorganic salts.

Safety Profile

Moderately toxic by skin contact, inhalation, intravenous, and intraperitoneal routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. A skin and eye irritant. Less toxic than dimethylformamide. Mutation data reported. Combustible when exposed to heat and flame. A moderate explosion hazard. Violent reaction with halogenated compounds (e.g., carbon tetrachloride, hexachlorocyclohexane) when heated above 9OOC. Iron powder catalyzes the reaction so that it initiates at 71OC. When heated to decomposition it emits toxic fumes of NOx

Safety

Dimethylacetamide is used in pharmaceutical preparations as a solvent in parenteral formulations and is generally regarded as a nontoxic material when used as an excipient. Animal toxicity studies indicate that dimethylacetamide is readily absorbed into the bloodstream following inhalation or topical application. Repeated exposure to dimethylacetamide may be harmful and can result in liver damage. High intravenous doses (>400mg/kg/day for 3 days) may be hallucinogenic.
LD50 (rabbit, SC): 9.6g/kg(11) LD50 (rat, IP): 2.75g/kg LD50 (rat, IV): 2.64g/kg LD50 (rat, oral): 4.93g/kg LD50 (mouse, inhalation): 7.2g/kg LD50 (mouse, IP): 2.8g/kg

Metabolism

Gas Chromatographie analysis of the urine of rats which had received dimethylacetamide by the subcutaneous route indicated the presence of N-methyl-acetamide and acetamide (Barnes and Ranta, 1972). Both metabolites were also found by the same authors in incubation mixtures of dimethylacetamide with rat liver homogenate. N-Methylacetamide was detected in the urine of human volunteers who had inhaled dimethylacetamide or absorbed dimethylacetamide vapor through the skin (Maxfield et al 1975). Measurement of the amount of the metabolite N-methylacetamide excreted by individuals exposed to dimethylacetamide vapors with or without face masks which allowed the inhalation of air free of dimethylacetamide indicated that more dimethylacetamide was absorbed through the lungs than through the skin. Interestingly, in this study, only 2-10% of the amount of dimethylacetamide inhaled was recovered in the urine in the form of N-methylacetamide. It has been suggested that the major urinary metabolite of the analogous dimethylformamide is N-(hydroxymethyl)-N-methylformamide and not N-methylformamide, since the carbinolamide decomposes on the gas chroma-tography column (to N-methylformamide) but is relatively stable in aqueous solution (Kestell et al 1986). In analogy, it would be logical to assume that the N-methylacetamide found in the urine after exposure to dimethylacetamide really arose from chemical breakdown of N-(hydroxymethyl)-N-methylacetamide during the analytical process. This contention, however, remains to be proven.

storage

Dimethylacetamide should be stored in an airtight container, protected from light, in a cool, dry place. Dimethylacetamide has an almost unlimited shelf-life when kept in closed containers and under nitrogen. It is combustible.

Purification Methods

Shake the amide with BaO for several days, reflux it with BaO for 1hour, then fractionally distil it under reduced pressure. Store it over molecular sieves. [Beilstein 4 IV 180.]

Incompatibilities

Dimethylacetamide is incompatible with carbon tetrachloride, oxidizing agents, halogenated compounds, and iron. It attacks plastic and rubber. Contact with strong oxidizers may cause fire.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM injections, IV injections and infusions). Included in parenteral medicines licensed in the UK.

N,N-Dimethylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products


N,N-Dimethylacetamide Suppliers

Global( 369)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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86-0551-65418684 info@tnjchem.com China 1659 55
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+86-371-55531817
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0371-55170693
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View Lastest Price from N,N-Dimethylacetamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 N,N-Dimethylacetamide
127-19-5
US $1.00 / kg 1kg 99% as request career henan chemical co
2018-12-21 N,N-Dimethylacetamide
127-19-5
US $1.00 / kg 1g 99% 100KG career henan chemical co
2018-12-21 N,N-Dimethylacetamide
127-19-5
US $1.00 / kg 1g 99% 100KG career henan chemical co

N,N-Dimethylacetamide Spectrum


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