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N,N-Diethyl-m-toluamide

Outline US Morflex one-step synthesis Insect repellent effects of various products Pregnant women should us N,N-Diethyl-3-methylbenzamide insect repellents with caution Chemical Properties Uses production method
N,N-Diethyl-m-toluamide
N,N-Diethyl-m-toluamide structure
CAS No.
134-62-3
Chemical Name:
N,N-Diethyl-m-toluamide
Synonyms
mgk;Off;DET;DEET;M-DET;Autan;Repel;Flypel;m-DETA;muscol
CBNumber:
CB8853064
Molecular Formula:
C12H17NO
Formula Weight:
191.27
MOL File:
134-62-3.mol

N,N-Diethyl-m-toluamide Properties

Melting point:
-45 °C
Boiling point:
111 °C1 mm Hg
Density 
0.998 g/mL at 20 °C(lit.)
vapor density 
6.7 (vs air)
vapor pressure 
<0.01 mm Hg ( 25 °C)
refractive index 
n20/D 1.523(lit.)
Flash point:
>230 °F
storage temp. 
room temp
pka
-1.37±0.70(Predicted)
form 
Liquid
color 
Clear
Specific Gravity
0.996
Water Solubility 
NEGLIGIBLE
Merck 
14,2856
BRN 
2046711
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Hydrolyzes slowly in water.
InChIKey
CXVBTGKUSLNJQZ-UHFFFAOYSA-N
CAS DataBase Reference
134-62-3(CAS DataBase Reference)
EWG's Food Scores
2-5
FDA UNII
FB0C1XZV4Y
NCI Dictionary of Cancer Terms
OFF
NIST Chemistry Reference
Diethyltoluamide(134-62-3)
EPA Substance Registry System
N,N-Diethyl-m-toluamide (134-62-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H336-H402-H302-H315-H319-H412
Precautionary statements  P261-P264-P270-P271-P280-P302+P352+P332+P313+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P403+P233-P405-P501-P280a-P301+P312a-P321-P332+P313-P501a-P301+P312+P330-P305+P351+P338-P273
Hazard Codes  Xn
Risk Statements  22-36/38-52/53
Safety Statements  61
RIDADR  2810
WGK Germany  2
RTECS  XS3675000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29242995
Toxicity LD50 orally in male rats (ml/kg): 2.43; in female rats: 1.78; dermally in rabbits: 3.18; LC50 by inhalation in rats (mg/l): 5.95 (U.S. EPA)

N,N-Diethyl-m-toluamide price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 36542 DEET PESTANAL , analytical standard 134-62-3 250mg $33.5 2021-03-22 Buy
Sigma-Aldrich 1197007 Diethyltoluamide United States Pharmacopeia (USP) Reference Standard 134-62-3 3g $366 2021-03-22 Buy
TCI Chemical D0097 N,N-Diethyl-m-toluamide >98.0%(GC) 134-62-3 25mL $14 2021-03-22 Buy
TCI Chemical D0097 N,N-Diethyl-m-toluamide >98.0%(GC) 134-62-3 500mL $55 2021-03-22 Buy
Alfa Aesar A17486 N,N-Diethyl-3-methylbenzamide, 97% 134-62-3 500g $58.1 2021-03-22 Buy

N,N-Diethyl-m-toluamide Chemical Properties,Uses,Production

Outline

N,N-Diethyl-3-methylbenzamide, with the chemical name diethyl toluamide, is a broad-spectrum insect repellent, having repellent effect upon a variety of biting insects in various environments , can be used to drive thorn flies, midges, black flies, chiggers, deer flies, fleas, gnats, horse flies, mosquitoes, sand flies, gnats, flies and stable flat lice. N,N-Diethyl-3-methylbenzamide is a development by the US Department of Agriculture during the World War II and has the patent, the product is designated as a repellent products for the use in the US Army in 1946. In 1957 the United States Environmental Protection Agency started civil application as an insect repellent registration, initially as a pesticide on the farm, and later the United States Government applied for its use in times of war, especially war in Vietnam and Southeast Asia, the United States Environmental Protection Agency statistics, every year nearly 40 percent of Americans use N,N-Diethyl-3-methylbenzamide-containing insect repellent, there are about 200 million people worldwide usage for over 40 years by more than 20,000 units of the research studies prove that N,N-Diethyl-3-methylbenzamide is the most secure and effective broad-spectrum repellent. World Health Organization has recommended the use of repellent products containing N,N-Diethyl-3-methylbenzamide to protect against insect vectors. Often mixed with other pesticides, but when it is mixed with an amino acid salts, pesticides toxicity will increase.

US Morflex one-step synthesis

US Morflex founded in 1927, located in Greensboro, United States, is the world's largest manufacturer of N,N-Diethyl-3-methylbenzamide . It owns 40 years of production and sales of N,N-Diethyl-3-methylbenzamide history, providing 60 percent of global consumption. Users include Johnson, Bayer and other famous enterprises, Morflex repellent cream formulation has cosmetic properties, non-irritating to human skin, more even applied than alcohol formula , more comfortable, no dry and tight and not greasy sense after the use of alcohol formula, specially formulated to lock N,N-Diethyl-3-methylbenzamide in sweat, friction, etc., can maintain long-lasting efficacy. Its production methods can be called "one step synthesis" , the advantage of "one step synthesis" is that it does not produce chemical synthesis additions-phosphoric acid, hydrochloric acid, amine hydrochloride or benzene. Phosphoric acid can cause greasy products, and other impurities are either irritating to the skin, or harmful to the human body. The multi-step synthesis methods currently used in the country can not avoid these harmful chemicals addenda.
The above information is edited by the Chemicalbook of Tian Ye.

Insect repellent effects of various products

The product containing chemical drug N,N-Diethyl-3-methylbenzamide owns best effects. Preferably, the time it can provide protection is proportional to the concentration of N,N-Diethyl-3-methylbenzamide products. For using products with N,N-Diethyl-3-methylbenzamide concentration at 23.8%, 20%, 6.6% and 4.8% , the protection times of the participants for the first time the average time being bitten are 302 minutes, 234 minutes, 112 minutes, 88 minutes, respectively .
The average time of plant protection products as follows: 2% soybean oil products for 95 minutes; citronella oil product containing different concentrations of 3 to 20 minutes; the average protection time containing eucalyptus oil repellent latest listing of 120 minute.
Many consumers believe that there is repellent function of the "Skin Bath Oil", provide protection only 10 minutes.
Products contains a chemical component (Merck insecticide product IR3535) , the average protection time is only 23 minutes.

Pregnant women should us N,N-Diethyl-3-methylbenzamide insect repellents with caution

N,N-Diethyl-3-methylbenzamide has potential risks to humans, especially pregnant women: after contacted with the skin, N,N-Diethyl-3-methylbenzamide-containing insect repellent products will penetrate into the blood, it is possible through the blood into the placenta, even umbilical cord, which may result in teratogenic. Pregnant women should avoid using N,N-Diethyl-3-methylbenzamide containing insect repellent products, pregnant women can choose to wear light-colored long-sleeved shirt and trousers, or using products containing natural ingredients repellent to prevent mosquito bites. If necessary, using insect repellent containing N,N-Diethyl-3-methylbenzamide products should also be with the lowest concentration and effective insect repellent components as possible.

Chemical Properties

Pale yellow liquid. There are light citrus fragrance smell.

Uses

1. As major components for a variety of solid, liquid mosquito repellent series.
2. Insect repellent, having unique effects for mosquito controlling . Formulation: 70%, 95% liquid.

production method

By the Inter-toluene chloride and diethyl amine reaction. Industrial products containing 5%-15% isomer.

Description

DEET was first developed and patented by the US Army in 1946. It was approved for general public use by the US Environmental Protection Agency (EPA) in 1957 and was reregistered in 1998. It has been estimated that more than 1.8 million kg (~4 million pounds) of DEET are used in the United States every year in more than 225 registered products. DEET is often sold and used in lotions or sprays with concentrations up to 100%. However, the Center for Disease Control recommends only 30–50% DEET to reduce the incidence of vector-borne disease transmission. Registered products must contain at least 95% of the meta-isomer, but small amounts of the more toxic ortho-isomer and the less toxic para-isomer are permitted.

Chemical Properties

Colorless to Amberlike Liquid

History

Formulations registered for direct human application contain from 4% to 100% DEET. DEET was developed as a joint effort by the Department of Defense and U.S. Department of Agriculture (USDA). After examining hundreds of compounds for their repellent capabilities in the 1940s, DEET was selected and patented by the U.S. Army in 1946.the USDA did not announce DEET’s discovery until 1954, and it was registered for public use in 1957. DEET is prepared from m-toluoyl chloride and diethylamine in benzene or ether.

Uses

Insect repellent

Uses

DEET is an Insect repellent.This compound is a contaminant of emerging concern (CECs).

Uses

DEET is used as an insect repellent.

Indications

DEET is an organic liquid that is an excellent mosquito repellent; stronger preparations of DEET are also effective against stable flies, although little protection is provided against ticks. Commercial preparations are available in aerosol, cream, or lotion form and vary in concentration from 6% to 100%. Because DEET is absorbed into the bloodstream, it should be applied sparingly. Lesser concentrations of DEET should be used whenever possible, with additional applications to the skin if needed. Reports of a toxic encephalopathy and brief seizures have been documented in children after overzealous use. Less serious neurologic side effects include confusion, irritability, and insomnia. Contact dermatitis has been observed with preparations containing higher concentrations of DEET.
Use preparations with <20% DEET in children. Avoid mucous membranes, broken skin, and hands of children, because they are often in contact with the mouth. Spray clothing instead of skin whenever possible, but avoid contact with rayon, acetate, or spandex, because these materials may be damaged by DEET.

Definition

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. It is the most widely used insect repellent worldwide.

General Description

Clear colorless or faintly yellow slightly viscous liquid. Faint pleasant odor.

Air & Water Reactions

N,N-Diethyl-3-methylbenzamide is sensitive to prolonged exposure to moisture. Insoluble in water.

Reactivity Profile

N,N-Diethyl-3-methylbenzamide is incompatible with strong acids, strong bases and strong oxidizing agents. N,N-Diethyl-3-methylbenzamide hydrolyzes slowly in the presence of water. N,N-Diethyl-3-methylbenzamide has a solvent effect on most plastics, paints, and varnishes. N,N-Diethyl-3-methylbenzamide is also incompatible with rayon, acetate or dynel clothing.

Fire Hazard

N,N-Diethyl-3-methylbenzamide is combustible.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and skin contact. Human systemic effects: coma, convulsions, dermatitis, mydriasis @upillary ddation), nausea or vomiting, stiffness. An eye and skin irritant. Experimental reproductive effects by skin contact. Mutation data reported. Can cause central nervous system disturbances. A pesticide. DEET is the active ingredient in most commercial insect repellents. When heated to decomposition it emits toxic fumes of NOx

Environmental Fate

Historically, it was thought that DEET worked via blocking of insect olfactory receptors and that DEET masked the target to the insect senses so the insect would not detect a food source. Instead, however, recent evidence indicates that the odor of DEET is what acts as the true repellent. A specific type of an olfactory receptor neuron in the antennal sensilla of mosquitoes was identified, and this neuron is activated by DEET. This activity is responsible for the properties that give DEET its repellent ability.
DEET is also toxic to the central nervous system(CNS). DEET acts as an inhibitor to the enzyme acetylcholinesterase which is required for the proper functioning of the human nervous system, other vertebrates, and insects. The enzyme acetylcholinesterase hydrolyzes acetylcholine, which is important to muscle control. When this process is inhibited, acetylcholine builds up in the synaptic cleft and causes neuromuscular paralysis and death by asphyxiation.

Toxicity evaluation

Little information is available on the environmental fate of DEET. DEET is stable to hydrolysis at environmental pH levels. The initial belief was that DEET was not likely to enter aquatic ecosystems because it was first registered for indoor use. It has been shown in several studies, however, that DEET is found in many waterways in the United States and around the world,such as groundwater, open water, sewage (influent and effluent), surface water, and septic waste in concentrations ranging from 30 ng l-1 to 13 μg l-1. A major source of introduction to aquatic environments is via sewage following washing and excretion by humans. The potential for DEET to be transported through soil is unknown. Although, some studies have shown that purification of water containing low concentrations of DEET using a combination of sand filtration, activated sludge treatment, and ozonation has a removal efficiency less than 69% (ozonation being the most efficient step). Sand filtration alone was inefficient, notably due to DEET’s hydrophilic nature (Kow < 3). This evidence suggests that DEET may not be retained in soil and other organic matter, but travels with groundwater into larger bodies of water, and more extreme measures than this must be taken to remove DEET from natural and domestic waters. On the other hand, one study noted that DEET ‘has an estimated Koc value of 536, indicating potential for sorption to suspended solids and sediment.’

N,N-Diethyl-m-toluamide Preparation Products And Raw materials

Raw materials

Preparation Products


N,N-Diethyl-m-toluamide Suppliers

Global( 394)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Crovell Biotech Co Ltd
19930504644 whatsapp +8619930504644
86-0311-66562153 sales4@crovellbio.com CHINA 2826 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Dalian Richfortune Chemicals Co., Ltd
0411-84820922
86-411-84821380 sales@richfortunechem.com China 300 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 536 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 292 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58

View Lastest Price from N,N-Diethyl-m-toluamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-14 Diethyltoluamide;DEET
134-62-3
US $105.00 / Kg/Drum 50KG 99% 1000tons/month Hebei Dongdu Import and Export Co. LTD
2021-09-07 Insecticide Deet /Tc Diethyltoluamide CAS 134-62-3
134-62-3
US $10.00 / KG 1g 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd
2021-09-07 N,N-Diethyl-m-toluamide
134-62-3
US $0.00 / Kg/Drum 1KG 99.9% 100000kg per month Wuhan Mulei New Material Technology Co. Ltd

N,N-Diethyl-m-toluamide Spectrum


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