ChemicalBook >> CAS DataBase List >>2-Chloro-5-nitropyridine
2-Chloro-5-nitropyridine
- CAS No.
- 4548-45-2
- Chemical Name:
- 2-Chloro-5-nitropyridine
- Synonyms
- Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine;6-Chloro-3-nitropyridine
- CBNumber:
- CB8853635
- Molecular Formula:
- C5H3ClN2O2
- Molecular Weight:
- 158.54
- MDL Number:
- MFCD00006240
- MOL File:
- 4548-45-2.mol
- MSDS File:
- SDS
Last updated:2024-03-21 17:31:59
| Melting point | 105-108 °C (lit.) |
|---|---|
| Boiling point | 256.6±20.0 °C(Predicted) |
| Density | 1.6616 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point | 158°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -4.22±0.10(Predicted) |
| form | Crystalline Powder |
| color | Light yellow to beige |
| Water Solubility | Solubility in hot methanol. Insoluble in water. |
| BRN | 120453 |
| InChI | InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H |
| InChIKey | BAZVFQBTJPBRTJ-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C([N+]([O-])=O)C=C1 |
| CAS DataBase Reference | 4548-45-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chloro-5-nitropyridine(4548-45-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US7175000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
2-Chloro-5-nitropyridine price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C61801 | 2-Chloro-5-nitropyridine 99% | 4548-45-2 | 5g | $36.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | C61801 | 2-Chloro-5-nitropyridine 99% | 4548-45-2 | 25g | $78 | 2024-03-01 | Buy |
| TCI Chemical | C0025 | 2-Chloro-5-nitropyridine >99.0%(GC) | 4548-45-2 | 5g | $17 | 2024-03-01 | Buy |
| TCI Chemical | C0025 | 2-Chloro-5-nitropyridine >99.0%(GC) | 4548-45-2 | 25g | $49 | 2024-03-01 | Buy |
| Alfa Aesar | A10709 | 2-Chloro-5-nitropyridine, 99% | 4548-45-2 | 25g | $97.65 | 2024-03-01 | Buy |
2-Chloro-5-nitropyridine Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal
Uses
2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.
Uses
2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.
Synthesis
Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.
Purification Methods
It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]
2-Chloro-5-nitropyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
4-(5-Nitropyridin-2-yl)morpholine
5-Nitropyridine-2-carboxylic acid
1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL
5-AMINO-2-METHOXY-ISONICOTINIC ACID
6-(1-PYRROLIDINYL)-3-PYRIDINAMINE
1-(5-aminopyridin-2-yl)piperidin-4-ol
3-Amino-6-morpholinopyridine
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE
5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE
5-Amino-2-chloropyridine
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Global( 651)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang TYSChem Co., Ltd. | +86-24-83607930 +8618640359690 | sales@honghuchem.com | China | 403 | 58 |
| Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 132 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 55 | 55 |
View Lastest Price from 2-Chloro-5-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | 2-Chloro-5-nitropyridine
4548-45-2
|
US $5.00 / kg | 1kg | ≥98% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-25 | 2-Chloro-5-nitropyridine
4548-45-2
|
US $15.00-50.00 / kg | 1kg | NLT98% | 5 ton per month | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2024-04-22 | 2-Chloro-5-nitropyridine
4548-45-2
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd |
-
- 2-Chloro-5-nitropyridine
4548-45-2
- US $5.00 / kg
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- 2-Chloro-5-nitropyridine
4548-45-2
- US $15.00-50.00 / kg
- NLT98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- 2-Chloro-5-nitropyridine
4548-45-2
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
4548-45-2(2-Chloro-5-nitropyridine)Related Search:
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2-Chloro-5-nitropyridine
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2-Chloro-5-nitropyridine, 99% 25GR
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2-Chloro-5-nitropyridine, 97+%
Chloro-5-nitropyrid
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Chloronitropyridine,99%
3-PYRIDINOL, 6-CHLORO-
2-choro-5-nitropyridine
2-CHLORO-5-NITROPYRIDINE (NON-REGULATED)
2-CHLORO-5-NITROPYRIDINE (REGULATED)
2-CHLORO-5-NITROPYRIDINE 99+%
Chloronitropyridine
2-Chloro-5-nitropyridine >
5-Bromo-4-methyl-2(2H)-pyridinone
4548-45-2 ISO 9001：2015 REACH
2-Chloro-5-nitropyridine ISO 9001：2015 REACH
2-Chloro--nitropyridine
2-chloro-5-nitripyridine
Piroctone Impurity 3
4548-45-2
4548-48-2
C5H3CIN2O2
Building Blocks
Pyridines
Heterocyclic Building Blocks
Halogenated Heterocycles
alkyl chloride |nitro-compound
Chlorinated heterocyclic series
Chloropyridines
Halopyridines
C5Heterocyclic Building Blocks
Halogenated Heterocycles
Heterocyclic Building Blocks
Pyridine series
Halides
Pyridines derivates
Pyridines, Pyrimidines, Purines and Pteredines
Heterocycles
blocks
Pyridines
Pyridine
compounds of pyridine
1
bc0001