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Actinomycin D

Actinomycin D
Actinomycin D structure
CAS No.
50-76-0
Chemical Name:
Actinomycin D
Synonyms
ad;actd;acto-d;nsc3053;AD(VAN);cosmegen;Cosmogen;nci-c04682;nci-co4682;oncostatink
CBNumber:
CB8853701
Molecular Formula:
C62 H86 N12 O16
Formula Weight:
1255.44
MOL File:
50-76-0.mol

Actinomycin D Properties

Melting point:
251-253 °C
Boiling point:
848°C (rough estimate)
Density 
1.0757 (rough estimate)
refractive index 
1.5700 (estimate)
Flash point:
87℃
storage temp. 
2-8°C
solubility 
ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
form 
powder
color 
red, powder
optical activity
[α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
Water Solubility 
SOLUBLE
Merck 
13,2828
BRN 
605235
Stability:
Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference
50-76-0(CAS DataBase Reference)
EWG's Food Scores
4
FDA UNII
1CC1JFE158
Proposition 65 List
Actinomycin D
EPA Substance Registry System
Actinomycin D (50-76-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS06
Signal word  Danger
Hazard statements  H227-H300-H351-H360
Precautionary statements  P264-P301+P310-P210e-P280a-P370+P378a-P403+P235-P201-P280-P301+P310a-P308+P313-P405-P501a
Hazard Codes  T+
Risk Statements  28-61-40-45-26/27/28
Safety Statements  53-36/37/39-45-1-36/37-28-22
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  AU1575000
8-10-21
HazardClass  6.1(a)
PackingGroup  II
HS Code  29419000
Toxicity LD50 oral in rat: 7200ug/kg

Actinomycin D price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 01815 Actinomycin D for fluorescence, ≥90% (HPLC), from 50-76-0 10mg-f $244 2018-11-22 Buy
Sigma-Aldrich 114666 Actinomycin D 50-76-0 1set $250 2019-12-02 Buy
Alfa Aesar J60148 Actinomycin D 50-76-0 5mg $89.8 2019-12-02 Buy
Alfa Aesar J67160 Actinomycin D, 1 mg/ml in DMSO, sterile-filtered 50-76-0 1ml $124 2019-12-02 Buy
Cayman Chemical 11421 Actinomycin D ≥95% 50-76-0 10mg $94 2018-11-13 Buy

Actinomycin D Chemical Properties,Uses,Production

Chemical Properties

red crystalline powder

Chemical Properties

Actinomycin D is a combustible, bright red crystalline solid.

Uses

Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic

Uses

An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.

Uses

antineoplastic, intercalating agent

Uses

Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumour activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumour cell death has been demonstrated to occur by apoptosis.

Indications

Dactinomycin (actinomycin D, Cosmegen) is one of a family of chromopeptides produced by Streptomyces. It is known to bind noncovalently to double-strand DNA by partial intercalation, inhibiting DNA-directed RNA synthesis. The drug is most toxic to proliferating cells, but it is not specific for any one phase of the cell cycle. Resistance to dactinomycin is caused by decreased ability of tumor cells to take up and retain the drug, and it is associated with cross-resistance to vinca alkaloids, the anthracyclines, and certain other agents (multidrug resistance).

brand name

Cosmegen (Ovation).

General Description

Bright red rhomboid prisms or red powder.

General Description

Dactinomycin is available in vials containing 0.5 mg of drugfor reconstitution in sterile water for IV administration Thisantibiotic is most effective in the treatment of rhabdomyosarcomaand Wilms tumor in children as well as in the treatmentof choriocarcinoma, Ewing sarcoma, Kaposi sarcoma, andtesticular carcinoma. The pharmacokinetics of dactinomycinhas not been well characterized, but it appears to concentratein nucleated blood cells. The agent is 5% to 15% plasmaprotein bound and is excreted mostly unchanged in urineand bile. Other metabolites have not been characterized.The terminal elimination half-life is 30 to 40 hours.Myelosuppression is dose limiting with both leucopenia andthrombocytopenia being the most likely presentation. Nauseaand vomiting occur shortly (2 hours) after treatment and maybe severe. Mucositis and diarrhea also result from irritation ofthe GI tract. Hair loss is commonly associated with the agentas is hyperpigmentation of the skin and erythema.

Air & Water Reactions

Water soluble.

Reactivity Profile

Actinomycin D can react with strong oxidizing agents, strong acids and strong bases.

Fire Hazard

Flash point data for Actinomycin D are not available. Actinomycin D is probably combustible.

Biological Activity

Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.

Mechanism of action

Dactinomycin is cleared rapidly from plasma, does not enter the brain, is not appreciably metabolized or protein bound, and is gradually excreted in both bile and urine.Virtually no drug is detected in CSF.

Clinical Use

Dactinomycin is used in curative combined treatment of Wilms’ tumor, Ewing’s sarcoma, rhabdomyosarcoma, and gestational choriocarcinoma. It is active in testicular tumors, lymphomas, melanomas, and sarcomas, although its use in most of these malignancies has been supplanted by other agents.

Side effects

The major side effects of dactinomycin are severe nausea, vomiting, and myelosuppression. Mucositis, diarrhea, alopecia, and radiation recall reactions may occur. The drug is immunosuppressive and carcinogenic.

Potential Exposure

An antibiotic product from streptomyces, used as anticancer and veterinary drug

Veterinary Drugs and Treatments

Dactinomycin has been used as adjunctive treatment of lymphoreticular neoplasms, bone and soft tissue sarcomas, and carcinomas in small animals. It appears to have low efficacy against most carcinomas and sarcomas. It is being investigated as a part of protocols for rescue therapy for canine lymphomas.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

It crystallises as bright red rhombic crystals from absolute EtOH or from MeOH/EtOH (1:3). It will also crystallise from EtOAc/cyclohexane (m 246-247o dec), CHCl3/pet ether ( m 245-246o dec), and EtOAc/MeOH/*C6H6 (m 241-243o dec). Its solubility in MeCN is 1mg/mL. [] D varies from -296o to -327o (c 0.2, MeOH). max (MeOH) 445, 240nm (log  4.43, 4.49), max (MeOH, 10N HCl, 1:1) 477nm (log  4.21) and max (MeOH, 0.1N NaOH) 458, 344, 285 (log  3.05, 4.28, 4.13). It is HIGHLY TOXIC, light sensitive and anti-neoplastic. [Bullock & Johnson, J Chem Soc 3280 1957, Beilstein 27 III/IV 9642.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Actinomycin D Preparation Products And Raw materials

Raw materials

Preparation Products


Actinomycin D Suppliers

Global( 228)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23047 58

View Lastest Price from Actinomycin D manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-30 Actinomycin D
50-76-0
US $0.00-0.00 / 公斤 1公斤 99.0% 800 ton Shaanxi Dideu Medichem Co. Ltd
2018-12-19 Actinomycin D
50-76-0
US $7.00 / kg 1kg 99% 100kg career henan chemical co

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