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Pyridoxine hydrochloride

CAS No.
58-56-0
Chemical Name:
Pyridoxine hydrochloride
Synonyms
Pyridoxine hydrochloride (Vitamin B6);campoviton6;5-Hydroxy-6-methyl-3,4-pyridinedimethanol;pyridox;paxadon;becilan;benadon;hexobion;hexermin;aderoxin
CBNumber:
CB8853882
Molecular Formula:
C8H12ClNO3
Molecular Weight:
205.64
MDL Number:
MFCD08064207
MOL File:
58-56-0.mol
MSDS File:
SDS
Last updated:2024-03-28 13:39:29

Pyridoxine hydrochloride Properties

Melting point 214-215 °C(lit.)
Density 1.2784 (rough estimate)
vapor density 7.1 (vs air)
refractive index 1.5800 (estimate)
Flash point 9℃
storage temp. room temp
solubility H2O: 0.1 g/mL at 20 °C, clear, colorless
form Crystalline Powder
color White to almost white
PH Range 3.2
Water Solubility 0.1 g/mL (20 ºC)
Sensitive Light Sensitive
Merck 14,7982
BRN 3632435
BCS Class 1
Stability Stable. Protect from air and light.
LogP -1.098 (est)
FDA 21 CFR 184.1676; 582.5676; 310.545
Substances Added to Food (formerly EAFUS) PYRIDOXINE HYDROCHLORIDE
SCOGS (Select Committee on GRAS Substances) Pyridoxine hydrochloride
CAS DataBase Reference 58-56-0(CAS DataBase Reference)
FDA UNII 68Y4CF58BV
NCI Drug Dictionary Hexa-Betalin
EPA Substance Registry System 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride (58-56-0)

Pharmacokinetic data

Protein binding High (as pyridoxal and pyridoxal phosphate)
Biological half-life 15-20 days / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-37/39-45-36/37-16-7-24/25
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  UV1350000
8-10
TSCA  Yes
HS Code  29362500
NFPA 704
1
0 0

Pyridoxine hydrochloride price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 80823 Pyridoxine hydrochloride certified reference material, TraceCERT 58-56-0 50mg $109 2024-03-01 Buy
Sigma-Aldrich 47862 Pyridoxine Hydrochloride (B6) analytical standard 58-56-0 1000mg $23.2 2024-03-01 Buy
Sigma-Aldrich 1587001 Pyridoxine hydrochloride United States Pharmacopeia (USP) Reference Standard 58-56-0 200mg $447 2024-03-01 Buy
Sigma-Aldrich BP458 Pyridoxine hydrochloride British Pharmacopoeia (BP) Reference Standard 58-56-0 100MG $221 2023-06-20 Buy
TCI Chemical P0561 Pyridoxine Hydrochloride >98.0%(HPLC)(T) 58-56-0 25g $44 2024-03-01 Buy
Product number Packaging Price Buy
80823 50mg $109 Buy
47862 1000mg $23.2 Buy
1587001 200mg $447 Buy
BP458 100MG $221 Buy
P0561 25g $44 Buy

Pyridoxine hydrochloride Chemical Properties,Uses,Production

Nutrition supplements

Pyridoxine hydrochloride(58-56-0) is the hydrochloride salt of Vitamin B6. Vitamin B6 (B6) is a water-soluble vitamin, which can be found in various foods such as fish, poultry, whole grains, legumes, banana, nuts, and sesame.Vitamin B6 has an important role in the metabolism of amino acids as a coenzyme, pyridoxal 5'-phosphate. 
B6 may exert an anticolon tumor effect by the protection of the colon epithelium from damage in rats treated with 1,2-dimethylhidrazine (DMH) and to decreased lithocholic acid, a colon carcinogen. Vitamin B6 may prevent such diseases by lowering inflammation. 

Chemical Properties

White or almost white, crystalline powder.

Uses

Pyridoxine Hydrochloride is an acid form of vitamin b6, a water- soluble vitamin. it is soluble in water, and slightly soluble in alco- hol. it is slowly affected by sunlight and is reasonably stable in air. it has a ph of 2.3–3.5. it is also termed vitamin b6 hydrochloride. see pyridoxine.

Uses

Pyridoxine is one of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). Pyridoxine has a role in transporting protein Bsu1, Pyridoxine contributes to thiamine uptak e; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.

Application

Pyridoxine hydrochloride has been used:
As a vitamin component in a chemically defined diet with balanced metal content for metal depletion studies;
As a component of chemically defined medium (CDM) to culture Staphylococcus aureus WSPPA;
As analytical reference standards for the determination of analytes in pharmaceutical preparations by chromatography and spectrophotometric techniques;
As a vitamin to study the impact of protein expression and post-translational modifications specifically charge heterogeneity;
As a medicine, it is used to prevent or treat certain neurological disorders (peripheral neuropathy) caused by certain drugs (e.g. isoniazid). It is also used in the treatment of certain hereditary disorders (e.g. flavoururic aciduria, hyperoxaluria, homocystinuria).

Definition

ChEBI: Pyridoxine hydrochloride is the hydrochloride salt of pyridoxine. It is a hydrochloride and a vitamin B6. It contains a pyridoxine.

brand name

Hexa-Betalin (Lilly).

General Description

Vitamin B6 has six forms namely, pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Pyridoxine is a is a water-soluble vitamin and a pyrimidine derivative of vitamin B6. It is considered heat and acid stable.

Biochem/physiol Actions

Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy.

Clinical Use

Vitamin B6

Side effects

Common side effects of Pyridoxine hydrochloride include: headache, nausea, drowsiness, mild numbness or tingling. Serious allergic reactions are rare and include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing, decreased sensation of touch, temperature, and vibration; loss of balance or coordination. If serious side effects occur please seek medical attention.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Metabolism

Pyridoxine is metabolised to its active form pyridoxamine phosphate. It is stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine.

Purification Methods

Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.]

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View Lastest Price from Pyridoxine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vitamin B6 pictures 2024-03-28 Vitamin B6
58-56-0
US $10.00 / kg 1kg 90% 10000 Changsha Staherb Natural Ingredients Co., Ltd.
Pyridoxine hydrochloride pictures 2024-03-28 Pyridoxine hydrochloride
58-56-0
US $6.00-0.20 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Pyridoxine hydrochloride pictures 2024-03-28 Pyridoxine hydrochloride
58-56-0
US $1000.00 / KG 0.10000000149011612KG 99% 10kg/Month Hebei Yime New Material Technology Co., Ltd.
  • Vitamin B6 pictures
  • Vitamin B6
    58-56-0
  • US $10.00 / kg
  • 90%
  • Changsha Staherb Natural Ingredients Co., Ltd.
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