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Dimethyl carbonate

Outline Reference quality standards The application of dimethyl carbonate Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage characteristics Extinguishing agent
Dimethyl carbonate
Dimethyl carbonate
CAS No.
616-38-6
Chemical Name:
Dimethyl carbonate
Synonyms
DMC;CH3OCOOCH3;METHYL CARBONATE;Dimethylcarbonat;dimetyl carbonate;DIMETHYL CARBONATE;dimethly carbonate;Methoxyformic acid;TwoMethyl carbonate;Dimethylcarbonate,99%
CBNumber:
CB8853983
Molecular Formula:
C3H6O3
Formula Weight:
90.08
MOL File:
616-38-6.mol

Dimethyl carbonate Properties

Melting point:
2-4 °C(lit.)
Boiling point:
90 °C(lit.)
Density 
1.069 g/mL at 25 °C(lit.)
vapor density 
3.1 (vs air)
vapor pressure 
18 mm Hg ( 21.1 °C)
refractive index 
n20/D 1.368(lit.)
Flash point:
65 °F
storage temp. 
Flammables area
solubility 
139g/l
form 
Liquid
color 
<50(APHA)
explosive limit
4.22-12.87%(V)
Water Solubility 
139 g/L
Sensitive 
Moisture Sensitive
Merck 
14,3241
BRN 
635821
Stability:
Stable. Highly flammable. Incompatible with strong oxidizing agents, potassium t-butoxide.
CAS DataBase Reference
616-38-6(CAS DataBase Reference)
NIST Chemistry Reference
Carbonic acid, dimethyl ester(616-38-6)
EPA Substance Registry System
Carbonic acid, dimethyl ester(616-38-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F
Risk Statements  11
Safety Statements  9-16-2017/9/16
RIDADR  UN 1161 3/PG 2
WGK Germany  1
RTECS  FG0450000
TSCA  Yes
HazardClass  3
PackingGroup  II
Hazardous Substances Data 616-38-6(Hazardous Substances Data)
Toxicity LD50 in rats (g/kg): 13.8 orally; 2.5 dermally; LC50 (4 hr) in rats (mg/l): 140 by inhalation (Ono)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Dimethyl carbonate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 13259 Dimethyl carbonate analytical standard 616-38-6 100mg $77.2 2018-11-13 Buy
Sigma-Aldrich 517127 Dimethyl carbonate anhydrous, ≥99% 616-38-6 1l $99.9 2018-11-13 Buy
TCI Chemical C0053 Dimethyl Carbonate >98.0%(GC) 616-38-6 25mL $14 2017-11-08 Buy
TCI Chemical C0053 Dimethyl Carbonate >98.0%(GC) 616-38-6 100mL $16 2017-11-08 Buy
Alfa Aesar A13104 Dimethyl carbonate, 99% 616-38-6 100g $16.3 2018-11-13 Buy

Dimethyl carbonate Chemical Properties,Uses,Production

Outline

Dimethyl carbonate is briefly referred to as DMC. At room temperature, it is a colorless and transparent liquid with a pungent odor with a relative density (D204) of 1.0694, a melting point of 4 °C, boiling point of 90.3 °C, the flash point being 21.7 °C (opening) and being 16.7 °C (closed ) and the refractive index (nd20) being 1.3687. It is flammable and non-toxic and is miserable with almost all organic solvents in any proportion with alcohols, ketones and esters. It is slightly soluble in water. It can be used as the methylating agent. Compared with other methylating reagent such as methyl iodide and dimethyl sulfate, dimethyl carbonate is less toxic, and biodegradable.
The past method of making dimethyl carbonate with phosgene as raw materials is not frequently used. Instead, people now adopt the catalytic oxidative carbonylation of methanol in the presence of oxygen which is more environmentally friendly than the previous method.
Dimethyl carbonate can enable to methylation of aniline, phenol and carboxylic acid. However, many reaction demands high-pressure. DBU can be added during reflux of DMC for catalyzing the methylation of carboxylic acid with dimethyl carbonate.

Reference quality standards

Index name battery grade excellent grade first grade qualified experimental methods
Appearance, colorless and transparent liquid
Dimethyl carbonate content% ≥99.9 ≥99.5 ≥99.0 ≥98.5 Gas Chromatography
Water, Water Content% ≤30ppm ≤0.10 ≤0.10 ≤0.10 GB606
Alkalinity mmol/10Og-≤0.10 ≤0.12 ≤0.12 Q/GNPC-JX 017
Non-volatile matter, %-≤0.02 ≤0.02 ≤0.02 GB6324.2
Peroxide (By H2O2) ≤5ppm---GB6016-85
Density (20 ℃), Density g/cm3 1.071 ± 0.005

The application of dimethyl carbonate

1, a novel type of low toxicity solvents and can substitute solvent such as toluene, xylene, ethyl acetate, butyl acetate, acetone or butanone in paints and adhesive industry, and is environmentally friendly green chemical products.
2, it is excellent methylating agent, carbonylation agent, hydroxymethylation agent and methoxylation agent and is a kind of chemical raw material of wide application.
3, it can be used as ideal substitute of highly toxic product such as phosgene, dimethyl sulfate, and methyl chloroformate.
4, it can be used for synthesizing polycarbonate, diphenyl carbonate, and isocyanate and so on.
5, in the field of medicine, it can be for the synthesis of anti-infective drugs, anti-inflammatory medicines, vitamin-class medicines and central nervous system drugs.
6, in the field of pesticides, it can be mainly used for the production of methyl isocyanate, thereby producing some carbamate drugs, pesticides (anisole).
7, it can be used as gasoline additives and lithium battery electrolyte and so on.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Chemical Properties

It is colorless liquid with a pungent odor. It is insoluble in water and soluble in alcohol, ether and other organic solvents.

Uses

Dimethyl carbonate product can be used as traditional substitute of toxic materials phosgene, dimethyl sulfate and methyl chloride and so on. It can be used for synthesis of polycarbonate, diphenyl carbonate, isocyanate and allyl diglycol carbonate ester; it can also used for the synthesis of various kinds of carbamate pesticides such as carbaryl and so on; it can also be used as intermediate of organic synthesis such as anisole, dimethoxybenzene, alkylated aryl amines, symmetrical diamine urea, methyl carbazate and so on; in the pharmaceutical industry, it can be used for making amino oxazolidinone, ciprofloxacin, β-keto acid ester class pharmaceutical intermediates. In addition, it can be used as additives of gasoline, diesel fuel, the refrigerator oil and solvent.

Production method

It can be produced through the reaction between methyl chloroformate ([79-22-1]) and methanol. The raw material, methyl chloroformate is produced from the reaction between methanol and phosgene. For the preparation, it is also plausible to have this phosgenation product been without isolation and add excess methanol for reflux reaction to synthesize dimethyl carbonate. The above reaction is called conventional phosgene method. 2 Transesterification methods: this is based on the transesterification between ethylene carbonate or propylene carbonate and methanol which can also produce dimethyl carbonate. This method has a high yield, small equipment corrosion and mild reaction conditions. However, the source of raw materials is limited by the development of petrochemical industry and the elements utilization rate is low. 3. Oxidative carbonylation method: this is based on the reaction of methanol, carbon monoxide and oxygen in the catalyst for direct synthesis of dimethyl carbonate. This method has a lot of advantages including easily available and cheap raw material, low toxicity and simple process. Therefore, it is the most promising approach. According to the technology conditions, it can be divided into liquid phase method and gas phase method. Gas phase can be further divided into one-step and two-step method, wherein the liquid phase of methanol oxidation-carbonylation method and the gas-phase oxidative carbonylation step method has been industrialized while the one-step way of gas-phase oxidative-carbonylation of methanol is still in development. 4. The synthesis reaction between methanol and CO2. This process route is still in development. 5. Synthesis method via reaction between methanol and urea. This process route is still in development.

Category

Flammable liquid

Toxicity grading

Low toxicity

Acute toxicity

Oral-rat LD50: 13000 mg/kg; Oral-Mouse LD50: 6000 mg/kg.

Flammability and hazard characteristics

It is flammable in case of fire, high temperature and oxidant with burning causing irritated fume.

Storage characteristics

Treasury: ventilation, low-temperature and dry; store it separately from oxidants.

Extinguishing agent

Dry powder dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Chemical Properties

colourless liquid

Uses

Environmentally benign substitute for dimethyl sulfate, q.v., and methyl halides in methylation reactions and for phosgene, q.v., in methylcarbonylation reactions.

General Description

A clear, colorless liquid with a pleasant odor. Flash point 66°F. Denser than water and slightly soluble in water. Vapors are heavier than air. Used to make other chemicals and as a special purpose solvent.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

Dimethyl carbonate reacts with acids to liberate heat along with methanol and carbon dioxide. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Purification Methods

If the reagent has broad intense bands at 3300cm-1 and above (i.e. OH stretching), then it should be purified further. Wash it successively with 10% Na2CO3 solution, saturated CaCl2, H2O, and dry it by shaking mechanically for 1hour with anhydrous CaCl2, and fractionate. [Bowden & Butler J Chem Soc 78 1939, Vogel J Chem Soc 1847 1948, Beilstein 3 IV 3.]

Dimethyl carbonate Preparation Products And Raw materials

Raw materials

Preparation Products


Dimethyl carbonate Suppliers

Global( 307)Suppliers
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Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
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klamar reagent 4001650900
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Nanjing Aopuqi Medical Technology Co., Ltd. 18061682508,QQ3590429773;18014482516,QQ977144864
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40399 62
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