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Thymine

Thymine Physiological function The Four DNA Bases Chemical properties Uses
Thymine
Thymine
CAS No.
65-71-4
Chemical Name:
Thymine
Synonyms
THYMIN;THYMINE;D-THYMIDINE;Thymine,>99%;Clospirazine;Thymine, 97+%;5-METHYLURACIL;ThyMine, 99% 5GR;METHYL(5-) URACIL;THYMINE extrapure
CBNumber:
CB8854081
Molecular Formula:
C5H6N2O2
Formula Weight:
126.11
MOL File:
65-71-4.mol

Thymine Properties

Melting point:
316 °C
Boiling point:
234.21°C (rough estimate)
Density 
1.3541 (rough estimate)
refractive index 
1.5090 (estimate)
storage temp. 
Store at RT.
form 
Powder
pka
9.94(at 25℃)
color 
White
Water Solubility 
Soluble in hot water. Slightly soluble in alcohol.
Merck 
14,9398
BRN 
607626
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
65-71-4(CAS DataBase Reference)
NIST Chemistry Reference
Thymine(65-71-4)
EPA Substance Registry System
2,4(1H,3H)-Pyrimidinedione, 5-methyl-(65-71-4)

SAFETY

Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  22-24/25-37/39-26
WGK Germany  2
RTECS  XP2100000
TSCA  Yes

Thymine price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1345 Thymine Pharmaceutical Secondary Standard; Certified Reference Material 65-71-4 250mg $81.3 2018-11-13 Buy
Sigma-Aldrich 1724532 Zidovudine Related Compound C United States Pharmacopeia (USP) Reference Standard 65-71-4 100mg $1110 2018-11-13 Buy
TCI Chemical T0234 Thymine >98.0%(HPLC)(T) 65-71-4 5g $14 2017-12-01 Buy
TCI Chemical T0234 Thymine >98.0%(HPLC)(T) 65-71-4 25g $32 2017-12-01 Buy
Alfa Aesar A15879 Thymine, 97% 65-71-4 25g $39.9 2018-11-13 Buy

Thymine Chemical Properties,Uses,Production

Thymine

Thymine, also known as 5-methyl uracil, the earliest isolated from calf thymus and then got the name, and is the major pyrimidine component of deoxyribonucleic acid. And it can be linked with deoxyribose through the glycoside chain to form deoxythymidine, the triphosphate of deoxythymidine triphosphate, the triphosphoric acid of which can compound to deoxythymidine triphosphate, which is a precursor of thymine during deoxyribonucleic acid biosynthesis.
structure of thymine
Figure 1 the structure of thymine.

Physiological function

Nucleotides consist of bases, pentoses and phosphates, and constitute the basic unit of biological macromolecular nucleic acid. According to the difference of pentose in nucleotide composition, nucleotides can be divided into ribonucleotides and deoxyribonucleotides, and there constitute the two types of nucleic acids: ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). The Compositions of nucleotide base are two categories, pyrimidine and purine. Pyrimidine is a 6-membered heterocyclic organic compound containing two nitrogen atoms. Common pyrimidine bases in nucleotides are cytosine (C), uracil (V) and thymine (T). Purine is a heterocyclic compound with four-nitrogen. Adenine (A) and bird purine (G) are the major purine bases that make up the nucleotides.Purine and pyrimidine are heterocyclic nitrogen-containing compounds that are necessary for biological (including human) nucleic acid metabolism. Purine, pyrimidine and ribose and phosphate combine to form RNA; purine, pyrimidine and deoxyribose and phosphate combine to produce DNA.DNA is the main chemical constituent of genes, which plays an important role in the transmission of genes, and the main function of RNA is the regulation of intracellular protein synthesis. the final metabolism product of Purine is mainly uric acid. The clinically relevant purines are adenine and guanine. Important pyrimidines are thymine, cytosine and uracil. In the purine and pyrimidine metabolism must have all kinds of enzymes involved in to make the metabolic process according to normal procedure, the lack of any kind of these enzymes can cause the corresponding purine or pyrimidine metabolic disorders, resulting in clinical-specific symptoms such as whey aciduria Xanthineuria and Lesch-Nyhan syndrome. Others, such as primary children with gout; uraemia with partial phosphoribosyl transferase deficiency; female intelligence retardation, mutations and hyperuricemia syndrome; 2,8-dehydroadenurine and deaminase deficiency in children is rare.
This information was edited by Chemicalbook Xiao Nan (2015-08-03).

The Four DNA Bases

There are four bases that support the formation of DNA. They are thymine, adenine, guanine, and cytosine and are also known by the acronyms T, A, G, and C. These bases are attracted to one another and form specific partnerships to help in the creation of DNA. DNA is a small molecule found in every cell of your body and is responsible for writing your body's genetic information.
DNA is best visualized by picturing a long, twisted, spiraling ladder. The inner portion of the ladder is constructed of rungs. If you picture the four bases of DNA as rungs that assist with the formation of the ladder, you can get a solid understanding of how the bases hold the DNA structure together. Just as the rungs have a responsibility to stabilize the ladder, the bases have a responsibility to stabilize the structure of DNA.
Thymine is an interesting base because it is the only one of the four bases found exclusively inside of DNA. The other bases are also found in RNA, which is often thought of DNA's cousin because of the close relationship and joint assistance the two often share genetic information transfer process.

Chemical properties

White crystalline powder, insoluble in water at room temperature, slightly soluble in alcohol, soluble in alkali, acid, formamide, DMF and pyridine. Melting point is 320-330 ° C.

Uses

(1) Thymine, along with adenine, guanine, and cytosine, is one of the four nucleic acid bases in DNA; thymine can be used to study chemical processes that affect DNA structure, such as a radiation-induced free radical product resulting in base cross-linking reaction and derivatization reaction. Thymine can be used to study the energy and hydrogen bonding kinetic parameters with other nucleic acid bases such as adenine; thymine is used for the development of (Hg) detectors with sensitive, nanoparticle-based structures and coordination chemistry.
(2) 5-methyl pyrimidine is an important component of genetic material, is the key intermediates of synthestising anti-AIDS drugs AZT, DDT and related drugs key intermediates, but also the starting material of synthetising anti-tumor, antiviral drug β-thymidine.

Chemical Properties

White crystalline powder

Uses

Thymine is a nitrogenous base component in the nucleic acid of DNA.

Uses

A nucleobase found in deoxyribonucleic acids (DNA).

Definition

ChEBI: A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group.

Purification Methods

Crystallise thymine from EtOAc, 10% aqueous EtOH or water. It has m 318-320o after sublimation at 200o/12mm. Purify it by preparative (2mm thick) TLC plates of silica gel, eluting with ethyl acetate/isopropanol/water (75:16:9, v/v; RF 0.75). The desired spot is localated with a uv lamp, cut the band from the plate, place it in MeOH, shake and filter it through a millipore filter, then evaporate. [Infante et al. J Chem Soc, Faraday Trans 1 68 1586 1973, Beilstein 24 H 353, 24 I 330, 24 II 183, 24 III/IV 1292.]

Thymine Preparation Products And Raw materials

Raw materials

Preparation Products


Thymine Suppliers

Global( 371)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22119 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10011 58
Chembon Pharmaceutical Co., Ltd.
+86-28-8425-2981
+86-28-8425-2965 info@chembon.com CHINA 724 55
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30308 84
Beijing Holiyang Chemical Co. Ltd. 010-69380220 ;13718199399
010-56108838 holiyangchem@163.com China 5781 56
parabiochem 025-83453382-8005
025-83453382 sale@parabiochem.com China 9625 55

View Lastest Price from Thymine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-03 Thymine
65-71-4
US $60.00 / KG 1KG 98% 2TON

65-71-4(Thymine)Related Search:


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