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Bromoform

Bromoform
Bromoform structure
CAS No.
75-25-2
Chemical Name:
Bromoform
Synonyms
CHBr3;BROMOFORM;NCI-C55130;tribromide;Bromoforme;Bromoformio;Bromoform,97%;Tribrommethan;Tribromometan;BroMoforM 
CBNumber:
CB8854218
Molecular Formula:
CHBr3
Formula Weight:
252.73
MOL File:
75-25-2.mol

Bromoform Properties

Melting point:
8 °C
Boiling point:
150 °C
Density 
2.89 g/mL at 25 °C(lit.)
vapor density 
8.7 (vs air)
vapor pressure 
5 mm Hg ( 20 °C)
refractive index 
n20/D 1.595(lit.)
Flash point:
148-150°C
storage temp. 
0-6°C
solubility 
water: soluble800 part(lit.)
pka
13.7(at 25℃)
form 
Liquid
color 
White to off-white
Water Solubility 
slightly soluble, 0.301 g/100 mL
Sensitive 
Light Sensitive
Merck 
14,1420
BRN 
1731048
Stability:
Stability May be an explosion hazard, especially when heated. Stable, but light-sensitive. Non-flammable. Incompatible with chemically active metals, strong bases. May contain ca 1% ethanol or 1-pentene (amylene) as a stabilizer.
InChIKey
DIKBFYAXUHHXCS-UHFFFAOYSA-N
CAS DataBase Reference
75-25-2(CAS DataBase Reference)
NIST Chemistry Reference
Methane, tribromo-(75-25-2)
EPA Substance Registry System
Methane, tribromo-(75-25-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N,F
Risk Statements  23-36/38-51/53-22-39/23/24/25-23/24/25-11
Safety Statements  28-45-61-28A-36/37-16-7-26-63
RIDADR  UN 2515 6.1/PG 3
WGK Germany  3
RTECS  PB5600000
8-10
TSCA  Yes
HS Code  2903 39 19
HazardClass  6.1
PackingGroup  III
Hazardous Substances Data 75-25-2(Hazardous Substances Data)
Toxicity LD50 s.c. in mice: 7.2 mmol/kg (Kutob, Plaa)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Bromoform price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 132942 Bromoform contains 1-3% ethanol as stabilizer, 96% 75-25-2 250g $65.6 2018-11-20 Buy
Sigma-Aldrich 132942 Bromoform contains 1-3% ethanol as stabilizer, 96% 75-25-2 1kg $317 2018-11-20 Buy
TCI Chemical B0806 Bromoform (stabilized with 2-Methyl-2-butene) [for Spectrophotometry] >99.0%(GC) 75-25-2 100mL $255 2018-11-22 Buy
TCI Chemical T0348 Bromoform (stabilized with Ethanol) >98.0%(GC) 75-25-2 25g $18 2018-11-22 Buy
Alfa Aesar A11904 Bromoform, 97%, stab. with ethanol 75-25-2 250g $100 2018-11-13 Buy

Bromoform Chemical Properties,Uses,Production

Chemical Properties

Bromoform is a colorless to pale yellow liquid with a high refractive index, very high density, and sweetish odor is similar to that of chloroform. It is slightly soluble in water and is nonflammable. Bromoform can form in drinking water as a by-product from the reaction of chlorine with dissolved organic matter and bromide ions.

Uses

  1. In separating mixtures of minerals. Bromoform is used as a fluid for mineral ore separation in geological tests, as a laboratory reagent, and in the electronics industry in quality assurance programs.
  2. Bromoform was formerly used as a solvent for waxes, greases, and oils, as an ingredient in fire-resistant chemicals and in fluid gauges. It was also used in the early part of this century as a medicine to help children with whooping cough get to sleep. Currently, bromoform is only produced in small amounts for use in laboratories and in geological and electronics testing.

General Description

A colorless liquid with a chloroform-like odor. Denser than water (density: 2.9 g / cm3 ) and slightly soluble in water. Hence sinks in water. Nonflammable. Toxic by ingestion, inhalation and skin absorption. A lachrymator. Used as a solvent and to make pharmaceuticals. Often stabilized with 1 to 3% ethanol.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Heating Bromoform to decomposition produces highly toxic fumes of carbon oxybromide (carbonyl bromide) and hydrogen bromide [Sax, 9th ed., 1996, p. 519]. Reaction with powdered potassium or sodium hydroxide, Li or Na/K alloys, is violently exothermic [Weizmann, C. et al., J. Am Chem. Soc., 1948, 70, p. 1189]. Explosive reaction with crown ethers in the presence of potassium hydroxide [Le Goaller, R. et al., Synth. Comm., 1982, 12, p. 1163].

Hazard

A questionable carcinogen. By ingestion, inhalation, and skin absorption. Liver damage, eye and upper respiratory tract irritant.

Health Hazard

Probable routes of human exposure to bromoform are inhalation, ingestion, and dermal contact.
Harmful if inhaled, swallowed, contacts skin or eyes or is absorbed through skin. It is a lachrymator, respiratory irritant, a narcotic and an hepatotoxin. Prolonged exposure may cause dermatitis. Inhalation causes irritation of nose and throat; provokes the flow of tears and saliva and reddening of the face. Ingestion may cause dizziness, disorientation and slurred speech, unconsciousness and death.
Non-Cancer: Bromoform is a central nervous system depressant, and its vapors are highly irritating to the eyes and respiratory tract. Limited observations in humans and animal studies indicate that acute inhalation or oral exposure to high levels of bromoform may cause liver and kidney injury. Chronic effects of bromoform exposure in humans have not been studied, although animal studies indicate adverse effects on the liver, kidney, and central nervous system (U.S. EPA, 1994a).

Fire Hazard

Behavior in Fire: May decompose to produce toxic gases and vapor such as hydrogen bromide and bromine.

Safety Profile

Suspected carcinogen with experimental neoplastigenic data. A human poison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Human mutation data reported. A lachrymator. It can damage the liver to a serious degree and cause death. It has anesthetic properties simdar to those of chloroform, but is not sufficiently volatile for inhalation purposes and is far too toxic for human use. As a sedative and antitussive its medicinal application has resulted in numerous poisonings. Inhalation of small amounts causes irritation, provoking the flow of tears and saliva, and reddening of the face. Abuse can lead to adhction and serious consequences. Explosive reaction with crown ethers or potassium hydroxide. Violent reaction with acetone or bases. Incompatible with Li or NaK alloys. When heated to decomposition it emits hghly toxic fumes of Br-. See also BROMIDES.

Purification Methods

The storage and stability of bromoform and chloroform are similar. Ethanol, added as a stabilizer, is removed by washing with H2O or with saturated CaCl2 solution, and the CHBr3, after drying with CaCl2 or K2CO3, is fractionally distilled. Prior to distillation, CHBr3 has also been washed with conc H2SO4 until the acid layer is no longer coloured, then dilute NaOH or NaHCO3, and H2O. A further purification step is fractional crystallisation by partial freezing. [Beilstein 1 IV 82.]

Bromoform Preparation Products And Raw materials

Raw materials

Preparation Products


Bromoform Suppliers

Global( 215)Suppliers
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Bromoform Spectrum


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