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ChemicalBook >> CAS DataBase List >>Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-

Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-

Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Structure
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- structure
CAS No.
1954650-11-3
Chemical Name:
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
Synonyms
JMS-053;Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-;JMS-053 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione
CBNumber:
CB88647551
Molecular Formula:
C13H8N2O2S
Molecular Weight:
256.28
MDL Number:
MFCD32206721
MOL File:
1954650-11-3.mol
Last updated:2024-07-02 08:55:39
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Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Properties

Density 1.53±0.1 g/cm3(Predicted)
form Solid
pka 8.47±0.20(Predicted)
color Light brown to brown
FDA UNII QBK5MBZ22Q

Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Chemical Properties,Uses,Production

Description

JMS-053 is a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. JMS-053 markedly enhanced microvascular barrier function after exposure of endothelial cells to vascular endothelial growth factor or lipopolysaccharide. JMS-053 also blocked the concomitant increase in RhoA activation and loss of Rac1. In human ovarian cancer cells, JMS-053 impeded migration, disrupted spheroid growth, and decreased RhoA activity. Importantly, JMS-053 displayed anticancer activity in a murine xenograft model of drug resistant human ovarian cancer.

Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- Suppliers

Global( 7)Suppliers
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 3711 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 024-024-88590548 18341751992 757984502@qq.com China 891 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 August@easycdmo.com China 10010 58
Supplier Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Shanghai Easy CDMO Co.,Ltd 58
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- JMS-053 JMS-053 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione 1954650-11-3