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Tiaramide

Tiaramide Structure
Tiaramide structure
CAS No.
32527-55-2
Chemical Name:
Tiaramide
Synonyms
NTA-194;Tiaramida;Rhc 2592a;Tiaramide;Brn 1030245;Einecs 251-083-7;Tiaramide USP/EP/BP;35941-71-0 (Mono-hydrochloride);4-[(5-Chloro-2-oxobenzothiazol-3-yl)acetyl]-1-piperazineethanol;4-((5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-1-piperazineethanol
CBNumber:
CB8875246
Molecular Formula:
C15H18ClN3O3S
Molecular Weight:
355.84
MDL Number:
MFCD00864788
MOL File:
32527-55-2.mol
Last updated:2023-05-04 17:34:37
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Tiaramide Properties

Melting point 159-161 °C
Boiling point 605.8±65.0 °C(Predicted)
Density 1.432±0.06 g/cm3(Predicted)
pka 6.2(at 25℃)
EWG's Food Scores 1
FDA UNII BB17WGM686

Tiaramide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0015864 5-CHLORO-3-(2-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-OXOETHYL)-1,3-BENZOTHIAZOL-2(3H)-ONE 95.00% 32527-55-2 5MG $495 2021-12-16 Buy
Product number Packaging Price Buy
API0015864 5MG $495 Buy

Tiaramide Chemical Properties,Uses,Production

Originator

Solantal,Fujisawa,Japan,1975

Definition

ChEBI: Tiaramide is a member of benzothiazoles.

Manufacturing Process

A solution of ethyl 5-chloro-2-oxo-3-benzo-thiazolineacetate (4.0 grams) in 1- (2-hydroxyethyl)piperazine is heated at 100°C for 24 hours. After cooling, the resulting mixture is extracted with chloroform. The chloroform extract is washed with water and shaken with 10% hydrochloric acid. The hydrochloric acid layer is washed with chloroform, made alkaline with 10% sodium hydroxide solution and extracted with chloroform. The chloroform extract is washed with water, dried over magnesium sulfate and concentrated. The residual oil (5.5 grams) is allowed to stand to form crystals, which are recrystallized from a mixture of ethyl acetate (40 ml) and ethanol (15 ml) to give 3-[4-(2-hydroxyethyl)-1-piperazinylcarbonylmethyl]-5-chloro-2(3H)- benzothiazolinone (3.2 grams) as colorless crystals, MP 159° to 161°C. The following is an alternate method of preparation: A mixture of 3-(1- piperazinyl)carbonylmethyl-5-chloro-2(3H)-benzothiazolinone (500 mg), anhydrous potassium carbonate (400 mg), 2-hydroxyethyl bromide (300 mg) and anhydrous ethanol (20 ml) is heated while refluxing for 5 hours. The reaction mixture is concentrated under reduced pressure. The residue is extracted with chloroform. The chloroform layer is dried over magnesium sulfate and concentrated. The residue is crystallized from a mixture of ethyl acetate and ethanol to give 3-[4-(2-hydroxyethyl]-1- piperazinylcarbonylmethyl]-5-chloro-2(3H)-benzothiazolinone (370 mg) as crystals, MP 159° to 160°C.

Therapeutic Function

Antiinflammatory

Tiaramide Preparation Products And Raw materials

Raw materials

1-(2-Hydroxyethyl)piperazine

Preparation Products

Tiaramide Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569265 +86-18612256290 1056@dideu.com China 3632 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Chengdu Kamel Pharmaceutical Co., Ltd 028-67136579 15828051124 sales@kamelpharm.com China 1751 55
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 61720 58
Bide Pharmatech Ltd. 400-6005915 sales@picasso-e.com China 39661 58
Shanghai Jieshikai Biotechnology Co. , Ltd. 021-57520305 13795461237 zhuruyan@jskchem.com China 49036 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
Chengdu Kamel Pharmaceutical Co., Ltd 55
Bide Pharmatech Ltd. 58
Bide Pharmatech Ltd. 58
Shanghai Jieshikai Biotechnology Co. , Ltd. 58

View Lastest Price from Tiaramide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tiaramide pictures 2021-07-20 Tiaramide
32527-55-2
 US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
Tiaramide USP/EP/BP pictures 2021-06-17 Tiaramide USP/EP/BP
32527-55-2
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Tiaramide pictures
  • Tiaramide
    32527-55-2
  • US $1.00-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd

32527-55-2(Tiaramide)Related Search:

Tiaramide 5-CHLORO-2-BENZOTHIAZOLINONE 1-ACETYL-4-(2-HYDROXY-ETHYL)-PIPERAZINE X HCL 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride 3-METHYL-2(3H)-BENZOTHIAZOLONE
1-Piperazineethanol, 4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)- (9ci) 1-Piperazineethanol, 4-((5-chloro-2-oxo-3-benzothiazolinyl)acetyl)- 35941-71-0 (Mono-hydrochloride) 4-((5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-1-piperazineethanol 5-Chlor-2,3-dihydro-3-(4-(2-hydroxyethyl)piperazinylcarbonylmethyl)-2-benzothiazolon Brn 1030245 Einecs 251-083-7 Rhc 2592a Tiaramida 4-[(5-Chloro-2-oxobenzothiazol-3-yl)acetyl]-1-piperazineethanol 5-Chloro-3-[[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl]-2,3-dihydrobenzothiazol-2-one NTA-194 4-[(5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl]piperazine-1-ethanol Tiaramide 2(3H)-Benzothiazolone, 5-chloro-3-[2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl]- Tiaramide USP/EP/BP 32527-55-2